- Sanger seq
Unknown
Sanger Sequencing - Human TRIM38 knockout A549 cell lysate (AB259208)
Allele-1 : 7 bp deletion in exon5
- Sanger seq
Unknown
Sanger Sequencing - Human TRIM38 knockout A549 cell lysate (AB259208)
Allele-2 : 1 bp insertion in exon5
보완 제품
제품 세부 정보
Knockout cell lysate achieved by CRISPR/Cas9.
REACH authorisation
Abcam has not and does not intend to apply for the REACH Authorisation of customers' uses of products that contain European Authorisation list (Annex XIV) substances.
It is the responsibility of our customers to check the necessity of application of REACH Authorisation, and any other relevant authorisations, for their intended uses.
Lysate preparation: Our lysates are made using RIPA buffer to which we add a protease inhibitor cocktail and phosphatase inhibitor cocktail (ratio: 300:100:10). This means that the protein of interest is denatured. If you require a native form of the protein please use the live cell version. Please refer to our lysis protocol for further details on how our lysates are prepared.
User storage instructions: Lyophilizate may be stored at 4°C. After reconstitution, store at -20°C for short-term storage or -80°C for long-term storage.
This product is subject to limited use licenses from The Broad Institute, ERS Genomics Limited and Sigma-Aldrich Co. LLC, and is developed with patented technology. For full details of the licenses and patents please refer to our limited use license and patent pages.
제품 구성
특성 및 보관 정보
유전자명
유전자 편집 종류
유전자 편집 방식
Knockout 검증
배송 시 보관 조건
적절한 단기 보관 조건
적절한 장기 보관 조건
추가 정보
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
The TRIM38 protein modulates immune responses. It does not form part of a complex but can act independently to regulate inflammatory signals. By targeting signaling proteins for ubiquitination TRIM38 plays a role in innate immunity influencing the production of inflammatory cytokines. This function is essential for keeping the immune response balanced and preventing excessive inflammation that can lead to tissue damage.
Pathways
TRIM38 influences the NF-kB and type I interferon pathways. These pathways are important in immune response modulation. In the NF-kB pathway TRIM38 controls the degradation of particular inhibitor proteins allowing the activation of this transcription factor which regulates genes involved in immune and inflammatory responses. TRIM38 also shares pathway interactions with proteins like TRAF6 and NEMO which contribute to its role in controlling the magnitude of these signaling cascades.
품질 관리
STR analysis
CSF1PO, D13S317, D7S820, D5S818, TH01, D16S539, TPOX
Cell culture
Biosafety level
EU: 1 US: 1
Adherent/suspension
Adherent
Gender
Male
Product promise
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com