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AB136933

Aldosterone ELISA kit

Aldosterone ELISA 키트

5

(2 리뷰들)

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(34 제품이 사용된 논문 )

Aldosterone ELISA kit is a competitive ELISA used to quantify aldosterone with a sensitivity of 4.7 pg/mL.

- Colorimetric competitive ELISA - 405 nm readout - works on any plate reader
- Wide measuring range: 3.9 - 250 pg/mL
- Cited in over 30 publications
2 이미지
Competitive ELISA - Aldosterone ELISA kit (AB136933)
  • cELISA

Supplier Data

Competitive ELISA - Aldosterone ELISA kit (AB136933)

Representative standard curve using ab136933.

Competitive ELISA - Aldosterone ELISA kit (AB136933)
  • cELISA

Lab

Competitive ELISA - Aldosterone ELISA kit (AB136933)

Aldosterone measured in various samples showing quantity (pg) per mL of sample tested.

주요 정보

샘플 타입

Urine, Plasma, Serum

Reacts with

Mammals, Rat, Mouse, Human

Sensitivity

= 4.7 pg/mL

검출 범위

3.9 - 250 pg/mL

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보완 제품

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Assay Kits

AB285306

Human Angiotensin II ELISA Kit

Competitive ELISA - Human Angiotensin II ELISA Kit (AB285306)

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "cELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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제품 세부 정보

REACH authorisation
Abcam has not and does not intend to apply for the REACH Authorisation of customers' uses of products that contain European Authorisation list (Annex XIV) substances.
It is the responsibility of our customers to check the necessity of application of REACH Authorisation, and any other relevant authorisations, for their intended uses.
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Precision

[ { "reproducibilityType": "Inter", "sample": "Aldosterone", "replicates": 13, "mean": "72.6 pg/mL", "standardDeviation": null, "coefficientOfVariability": "10.8" }, { "reproducibilityType": "Inter", "sample": "Aldosterone", "replicates": 13, "mean": "24.4 pg/mL", "standardDeviation": null, "coefficientOfVariability": "18" }, { "reproducibilityType": "Inter", "sample": "Aldosterone", "replicates": 13, "mean": "10.8 pg/mL", "standardDeviation": null, "coefficientOfVariability": "16.3" }, { "reproducibilityType": "Intra", "sample": "Aldosterone", "replicates": 20, "mean": "13.9 pg/mL", "standardDeviation": null, "coefficientOfVariability": "6.6" }, { "reproducibilityType": "Intra", "sample": "Aldosterone", "replicates": 20, "mean": "27.7 pg/mL", "standardDeviation": null, "coefficientOfVariability": "4.4" }, { "reproducibilityType": "Intra", "sample": "Aldosterone", "replicates": 20, "mean": "84.8 pg/mL", "standardDeviation": null, "coefficientOfVariability": "4.5" } ]
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Recovery

[ { "sample": "Serum", "range": "57.6 - 76.1 %", "average": "= 69.8" }, { "sample": "Plasma", "range": "88.1 - 124.2 %", "average": "= 108.3" }, { "sample": "Urine", "range": "77.1 - 124.8 %", "average": "= 98.7" } ]
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제품 구성

{ "values": { "1x96Tests": { "sellingSize": "1 x 96 Tests", "publicAssetCode":"ab136933-1x96Tests", "assetComponentDetails": [ { "size":"1 x 5 mL", "name":"Stop Solution", "number":"AB136933-CMP06", "productcode":"" }, { "size":"1 x 1 Unit", "name":"Donkey anti-sheep IgG Microplate (12 x 8 wells)", "number":"AB136933-CMP09", "productcode":"" }, { "size":"1 x 27 mL", "name":"Assay Buffer", "number":"AB136933-CMP04", "productcode":"" }, { "size":"1 x 20 mL", "name":"pNpp Substrate", "number":"AB136933-CMP08", "productcode":"" }, { "size":"1 x 250 µL", "name":"Aldosterone Standard", "number":"AB136933-CMP03", "productcode":"" }, { "size":"1 x 1 Unit", "name":"Plate Sealer", "number":"AB136933-CMP07", "productcode":"" }, { "size":"1 x 27 mL", "name":"20X Wash Buffer Concentrate", "number":"AB136933-CMP05", "productcode":"" }, { "size":"1 x 5 mL", "name":"Aldosterone Antibody", "number":"AB136933-CMP01", "productcode":"" }, { "size":"1 x 5 mL", "name":"Aldosterone Alkaline Phosphatase Conjugate", "number":"AB136933-CMP02", "productcode":"" } ] } } }
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특성 및 보관 정보

배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
-20°C
적절한 장기 보관 조건
Multi
보관 정보
Please refer to protocols
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Aldosterone sometimes called aldosteron or aldo sterone is a steroid hormone with a molecular weight of approximately 360 Da. It is synthesized and secreted by the adrenal cortex specifically in the zona glomerulosa which is the outermost layer. The production of aldosterone involves a series of enzymatic actions converting cholesterol into progesterone and eventually forming this mineralocorticoid hormone. Its expression is facilitated by the circadian rhythm and influenced by plasma potassium levels and the renin-angiotensin system.
Biological function summary

Aldosterone plays an essential role in regulating electrolyte balance and blood pressure by increasing sodium reabsorption and potassium excretion in the kidney's distal tubules and collecting ducts. As part of a system with other hormones like cortisol and aldosterone it modulates the body's fluid and electrolyte equilibrium. Through binding and activating the mineralocorticoid receptor aldosterone adjusts ion transport in epithelial and non-epithelial tissues impacting processes like fluid retention and blood pressure maintenance.

Pathways

Aldosterone significantly influences the renin-angiotensin-aldosterone system (RAAS) and the sodium-potassium pump. The RAAS is critical in maintaining blood pressure and fluid balance where aldosterone works closely with angiotensin II and renin. Within this pathway aldosterone promotes sodium reabsorption leading to water retention and its action is closely tied to the function of the sodium-potassium pump which further regulates cellular ionic balance and impacts systemic vascular resistance.

Aldosterone is associated with conditions such as hyperaldosteronism and hypertension. In hyperaldosteronism excessive aldosterone levels cause high blood pressure and hypokalemia due to increased sodium and water retention. This condition often results from adrenal gland abnormalities that affect aldosterone production. Proteins related to this disorder through the RAAS include angiotensin-converting enzyme and angiotensinogen highlighting the interplay between aldosterone and these components. Additionally aldosterone has links to congestive heart failure where its overactivity can exacerbate fluid overload worsening cardiac function.
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제품 프로토콜

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타겟 정보

See full target information Aldosterone
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제품이 사용된 논문 (34)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Cell death & disease 16:496 PubMed40617804

2025

Nedd4-2 ablation in kidney improves glycaemic control in diabetic mice.

Applications

Unspecified application

Species

Unspecified reactive species

Jantina A Manning,Shilpanjali Jesudason,Paul A B Moretti,Stuart M Pitson,Angela S Y Chou,Meriam Shabbar,Sonia Saad,Carol Pollock,Sharad Kumar

Endocrinology 165: PubMed38376928

2024

Impact of Exposure to a Mixture of Organophosphate Esters on Adrenal Cell Phenotype, Lipidome, and Function.

Applications

Unspecified application

Species

Unspecified reactive species

Zixuan Li,Barbara F Hales,Bernard Robaire

Endocrinology 164: PubMed37522340

2023

The Organophosphate Esters Used as Flame Retardants and Plasticizers Affect H295R Adrenal Cell Phenotypes and Functions.

Applications

Unspecified application

Species

Unspecified reactive species

Zixuan Li,Bernard Robaire,Barbara F Hales

Pediatric blood & cancer 70:e30578 PubMed37449940

2023

Metabolomic profiling reveals the mechanisms underlying the nephrotoxicity of methotrexate in children with acute lymphoblastic leukemia.

Applications

Unspecified application

Species

Unspecified reactive species

Yu Cheng,Yanan Chen,Mingming Zhao,Minglu Wang,Maobai Liu,Limei Zhao

PloS one 17:e0270093 PubMed36395344

2022

Effectiveness of short-term isothermic-heat acclimation (4 days) on physical performance in moderately trained males.

Applications

Unspecified application

Species

Unspecified reactive species

Jake Shaw,Cory Walkington,Edward Cole,Damien O Gleadall-Siddall,Rachel Burke,James Bray,Andrew J Simpson,Rebecca V Vince,Andrew T Garrett

European journal of histochemistry : EJH 66: PubMed36373350

2022

Combination of tolvaptan and valsartan improves cardiac and renal functions in doxorubicin-induced heart failure in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Fengqin Yan,Hong Zhu,Yingxia He,Qinqin Wu,Xiaoyu Duan

Journal of the Endocrine Society 7:bvac143 PubMed36405866

2022

Effect of Inactivation of and in the Mouse Adrenal Cortex.

Applications

Unspecified application

Species

Unspecified reactive species

Nour Abou Nader,Étienne Blais,Guillaume St-Jean,Derek Boerboom,Gustavo Zamberlam,Alexandre Boyer

Biological & pharmaceutical bulletin 45:1321-1331 PubMed36047201

2022

The Role of SGLT2 Inhibitor Ipragliflozin on Cardiac Hypertrophy and microRNA Expression Profiles in a Non-diabetic Rat Model of Cardiomyopathy.

Applications

Unspecified application

Species

Unspecified reactive species

Toshiyuki Takasu

Biomedicines 10: PubMed35885053

2022

Effect of Anti-Hypertensive Medication on Plasma Concentrations of Lysyl Oxidase: Evidence for Aldosterone-IL-6-Dependent Regulation of Lysyl Oxidase Blood Concentration.

Applications

Unspecified application

Species

Unspecified reactive species

Rolf Schreckenberg,Oliver Dörr,Sabine Pankuweit,Bernhard Schieffer,Christian Troidl,Holger Nef,Christian W Hamm,Susanne Rohrbach,Ling Li,Klaus-Dieter Schlüter

Journal of the Endocrine Society 6:bvab187 PubMed35047715

2022

Changes of FGF23 and the Renin-Angiotensin-System in Male Mouse Models of Chronic Kidney Disease and Cardiac Hypertrophy.

Applications

Unspecified application

Species

Unspecified reactive species

Kohei Okamoto,Hideki Fujii,Kentaro Watanabe,Shunsuke Goto,Keiji Kono,Shinichi Nishi
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Product promise

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