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AB314390

Human SECTM1 ELISA Kit

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Human SECTM1 ELISA Kit is a Sandwich ELISA for the measurement of Human SECTM1 in Human in Biofluids, Cell Culture Media samples.

대체 명칭 보기

K12, SECTM1, Secreted and transmembrane protein 1, Protein K-12

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Sandwich ELISA - Human SECTM1 ELISA Kit (AB314390)
  • sELISA

Supplier Data

Sandwich ELISA - Human SECTM1 ELISA Kit (AB314390)

Example of standard curve using ab314390. This standard curve is for demonstrative purposes only. A standard curve must be run with each assay.

주요 정보

검출 방식

Colorimetric

샘플 타입

Serum, Plasma, Cell culture supernatant

Reacts with

Human

분석 유형

Sandwich

결과 유형

Quantitative

Sensitivity

= 1.85 ng/mL

검출 범위

1.85 - 500 ng/mL

분석 플랫폼

Pre-coated microplate (12 x 8 well strips)

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보완 제품

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "sELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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제품 세부 정보

Human SECTM1 ELISA Kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human SECTM1 in serum, plasma (collect plasma using heparin as an anticoagulant. EDTA and Citrate are not recommended in this assay), and cell culture supernatants. This assay employs an antibody specific for human SECTM1 coated on a 96-well plate.
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Recovery

[ { "sample": "Serum", "range": "71 - 120 %", "average": "= 87.6" }, { "sample": "Plasma", "range": "91 - 140 %", "average": "= 118.1" }, { "sample": "Cell culture media", "range": "81 - 100 %", "average": "= 90.05" } ]
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제품 구성

{ "values": { "1x96Tests": { "sellingSize": "1 x 96 Tests", "publicAssetCode":"ab314390-1x96Tests", "assetComponentDetails": [ { "size":"1 x 1 Unit", "name":"Human SECTM1 Antibody-coated ELISA Plate", "number":"AB314390-CMP08", "productcode":"" }, { "size":"1 x 8 mL", "name":"Stop Solution; 0.2M Sulfuric Acid", "number":"AB314390-CMP06", "productcode":"" }, { "size":"2 x 1 Vial", "name":"Lyophilized Human SECTM1 Protein Standard", "number":"AB314390-CMP10", "productcode":"" }, { "size":"2 x 1 Vial", "name":"Biotinylated Human SECTM1 Detection Antibody", "number":"AB314390-CMP09", "productcode":"" }, { "size":"1 x 12 mL", "name":"TMB One-Step Substrate Reagent", "number":"AB314390-CMP07", "productcode":"" }, { "size":"1 x 15 mL", "name":"5X Assay Diluent (Item E2)", "number":"AB314390-CMP05", "productcode":"" }, { "size":"1 x 25 mL", "name":"20X Wash Buffer", "number":"AB314390-CMP04", "productcode":"" }, { "size":"1 x 200 µL", "name":"100X HRP-Streptavidin", "number":"AB314390-CMP03", "productcode":"" } ] } } }
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특성 및 보관 정보

배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
-20°C
적절한 장기 보관 조건
-20°C
보관 정보
-20°C
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

SECTM1 also known as Secreted and Transmembrane 1 and sometimes as K12 is a protein with a molecular mass of approximately 28 kDa. It expresses both membrane-bound and soluble forms found mainly in epithelial cells and in some types of immune cells such as monocytes. SECTM1 resides in the Golgi apparatus and can be secreted outside the cell indicating its role in cell signaling and communication.
Biological function summary

The protein plays a role in modulating immune responses. SECTM1 interacts with CD7 a cell surface glycoprotein found on T cells and natural killer cells influencing their activation and proliferation. This interaction is important for immune system regulation and SECTM1 can function together with other immune-related proteins but usually operates independently rather than as part of a larger protein complex.

Pathways

SECTM1 is involved in immunological pathways particularly those governing T-cell activation and the broader inflammatory response. Within these pathways SECTM1 connects with proteins like CD7 and is associated with the PI3K/Akt signaling cascade. This linkage influences cell survival and growth bridging innate and adaptive immunity.

SECTM1 has associations with several inflammatory and autoimmune conditions as well as cancer. Abnormal expression levels of SECTM1 have implications in disorders such as rheumatoid arthritis where its interaction with CD7 appears to play a role in disease progression. Similarly in certain cancers altered SECTM1 expression leads to changes in immune cell behavior affecting tumor growth and metastasis.
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제품 프로토콜

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타겟 정보

May be involved in thymocyte signaling.
See full target information SECTM1
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websiteProtocolBooklet
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Product promise

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