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AB313508

Human XPNPEP1 ELISA Kit

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Human XPNPEP1 ELISA Kit is a Sandwich ELISA for the measurement of Human XPNPEP1 in Human in Cell Culture Media, Biofluids samples.

대체 명칭 보기

XPNPEPL, XPNPEPL1, XPNPEP1, Xaa-Pro aminopeptidase 1, Aminoacylproline aminopeptidase, Cytosolic aminopeptidase P, Soluble aminopeptidase P, X-Pro aminopeptidase 1, sAmp

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Sandwich ELISA - Human XPNPEP1 ELISA Kit (AB313508)
  • sELISA

Supplier Data

Sandwich ELISA - Human XPNPEP1 ELISA Kit (AB313508)

Example of standard curve using ab313508. This standard curve is for demonstrative purposes only. A standard curve must be run with each assay.

주요 정보

검출 방식

Colorimetric

샘플 타입

Cell culture supernatant, Serum, Plasma

Reacts with

Human

분석 유형

Sandwich

결과 유형

Quantitative

Sensitivity

= 2.1 ng/mL

분석 플랫폼

Pre-coated microplate (12 x 8 well strips)

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "sELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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제품 세부 정보

Human XPNPEP1 ELISA kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human XPNPEP1 in serum, plasma and cell culture supernatants. This assay employs an antibody specific for human XPNPEP1 coated on a 96-well plate.
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Recovery

[ { "sample": "Cell culture media", "range": "78 - 105 %", "average": "= 91.93" }, { "sample": "Plasma", "range": "71 - 98 %", "average": "= 82.79" }, { "sample": "Serum", "range": "70 - 107 %", "average": "= 87.79" } ]
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제품 구성

{ "values": { "1x96Tests": { "sellingSize": "1 x 96 Tests", "publicAssetCode":"ab313508-1x96Tests", "assetComponentDetails": [ { "size":"1 x 25 mL", "name":"20X Wash Buffer", "number":"AB313508-CMP04", "productcode":"" }, { "size":"1 x 15 mL", "name":"5X Assay Diluent D (Item K)", "number":"AB313508-CMP06", "productcode":"" }, { "size":"1 x 12 mL", "name":"TMB One-Step Substrate Reagent", "number":"AB313508-CMP08", "productcode":"" }, { "size":"1 x 1 Unit", "name":"Human XPNPEP1 Antibody-coated ELISA Plate", "number":"AB313508-CMP09", "productcode":"" }, { "size":"1 x 8 mL", "name":"Stop Solution; 0.2M Sulfuric Acid", "number":"AB313508-CMP07", "productcode":"" }, { "size":"1 x 200 µL", "name":"200X HRP-Streptavidin", "number":"AB313508-CMP03", "productcode":"" }, { "size":"1 x 15 mL", "name":"5X Assay Diluent B (Item E)", "number":"AB313508-CMP05", "productcode":"" }, { "size":"2 x 1 Vial", "name":"Lyophilized Human XPNPEP1 Protein Standard", "number":"AB313508-CMP11", "productcode":"" }, { "size":"2 x 1 Vial", "name":"Biotinylated Human XPNPEP1 Detection Antibody", "number":"AB313508-CMP10", "productcode":"" } ] } } }
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특성 및 보관 정보

배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
-20°C
적절한 장기 보관 조건
-20°C
보관 정보
-20°C
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

The XPNPEP1 protein also known as X-prolyl aminopeptidase 1 or aminopeptidase P functions as a cytosolic enzyme and possesses a zinc-binding motif. It cleaves N-terminal amino acids from peptides containing proline. This enzyme has a mass of approximately 65 kDa. XPNPEP1 is expressed in various tissues with high expression levels observed in the kidney and liver. It operates as a monomeric enzyme and requires metal ions for its catalytic activity.
Biological function summary

XPNPEP1 plays a role in protein and peptide metabolism by processing proline-containing substrates. It does not associate with any catalytic complexes but functions autonomously to modulate peptide availability and activity. Its enzymatic activity aids in regulating peptides involved in cellular signaling and function. XPNPEP1 helps maintain homeostasis by ensuring the correct processing and degradation of proline-containing peptides which can influence numerous physiological processes.

Pathways

XPNPEP1 participates in the renin-angiotensin system (RAS) and the bradykinin degradation pathway. In the RAS XPNPEP1 modulates angiotensin molecules therefore impacting blood pressure regulation. It interacts with angiotensin-converting enzyme (ACE) within this system. In the bradykinin degradation pathway XPNPEP1 helps break down bradykinin peptides therefore preventing prolonged inflammatory responses and vascular permeability changes. Its activity is important in maintaining balance within these systems.

XPNPEP1 has links to hypertension and renal diseases due to its involvement in blood pressure and fluid balance regulation. Its association with ACE makes it relevant to conditions like hypertension where ACE inhibitors are often treatment choices. Additionally changes in XPNPEP1 expression or activity can contribute to renal dysfunction given its significant expression in kidney tissues. Research on XPNPEP1 could lead to better understanding and treatment of these cardiovascular and renal conditions.
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제품 프로토콜

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타겟 정보

Metalloaminopeptidase that catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro (PubMed : 11106490, PubMed : 18515364, PubMed : 35165443). Contributes to the degradation of bradykinin (PubMed : 11106490).
See full target information XPNPEP1
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websiteProtocolBooklet
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Product promise

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