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AB237654

anti-Rituximab ELISA Kit

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anti-Rituximab ELISA Kit is a ELISA for the measurement of anti-Rituximab in Human in Biofluids samples.
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Sandwich ELISA - anti-Rituximab ELISA Kit (AB237654)
  • sELISA

Supplier Data

Sandwich ELISA - anti-Rituximab ELISA Kit (AB237654)

Typical Standard Curve : This standard curve is for demonstration only. A standard curve must be run with each assay.

주요 정보

검출 방식

Colorimetric

샘플 타입

Plasma, Serum

Reacts with

Human

결과 유형

Quantitative

Sensitivity

= 7.5 ng/mL

검출 범위

10 - 160 ng/mL

분석 플랫폼

Microplate

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보완 제품

Assay Kits

AB237640

Rituximab ELISA Kit

Sandwich ELISA - Rituximab ELISA Kit (AB237640)

  • 0
  • 0
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Human Factor XI ELISA Kit

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Primary Antibodies

AB52917

Anti-VEGFA antibody [EP1176Y] - C-terminal

RabMAb|Recombinant|Lab Essentials|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-VEGFA antibody [EP1176Y] - C-terminal (AB52917)

  • 5
  • 9
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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제품 세부 정보

anti-Rituximab ELISA Kit (ab237654) is designed to quantify/measure the antibody against Rituximab with high specificity and sensitivity in biological matrices.

This product is manufactured by BioVision, an Abcam company and was previously called E4385 BioSim™ anti-Rituximab (Mabthera®) (Human) ELISA Kit. E4385-100 is the same size as the 96 test size of ab237654.

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Precision

[ { "reproducibilityType": "Inter", "sample": "Overall", "replicates": 0, "mean": null, "standardDeviation": null, "coefficientOfVariability": "< 20" }, { "reproducibilityType": "Intra", "sample": "Overall", "replicates": 0, "mean": null, "standardDeviation": null, "coefficientOfVariability": "< 20" } ]
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Recovery

[ { "sample": "Serum", "range": "70 - 130 %", "average": null } ]
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제품 구성

{ "values": { "96Test": { "sellingSize": "96 Test", "publicAssetCode":"ab237654-96Test", "assetComponentDetails": [ { "size":"1 x 12 mL", "name":"TMB substrate", "number":"AB237654-CMP14", "productcode":"" }, { "size":"1 x 1 Unit", "name":"Micro ELISA Plate", "number":"AB237654-CMP04", "productcode":"" }, { "size":"2 x 1 Unit", "name":"Plate sealers", "number":"AB237654-CMP07", "productcode":"" }, { "size":"1 x 12 mL", "name":"Confirmation Reagent", "number":"AB237654-CMP02", "productcode":"" }, { "size":"1 x 50 mL", "name":"Assay Buffer", "number":"AB237654-CMP01", "productcode":"" }, { "size":"1 x 12 mL", "name":"Stop Solution", "number":"AB237654-CMP15", "productcode":"" }, { "size":"1 x 50 mL", "name":"Wash buffer (20X)", "number":"AB237654-CMP13", "productcode":"" }, { "size":"1 x 1 mL", "name":"Rituximab Standard F", "number":"AB237654-CMP11", "productcode":"" }, { "size":"1 x 1 mL", "name":"Rituximab Standard E", "number":"AB237654-CMP10", "productcode":"" }, { "size":"1 x 1 mL", "name":"Rituximab Standard D", "number":"AB237654-CMP09", "productcode":"" }, { "size":"1 x 1 mL", "name":"Rituximab Standard C", "number":"AB237654-CMP08", "productcode":"" }, { "size":"1 x 1 mL", "name":"Rituximab Standard B", "number":"AB237654-CMP06", "productcode":"" }, { "size":"1 x 1 mL", "name":"Rituximab Standard A", "number":"AB237654-CMP05", "productcode":"" }, { "size":"1 x 12 mL", "name":"Peroxidase Conjugate", "number":"AB237654-CMP03", "productcode":"" }, { "size":"1 x 1 mL", "name":"Control - Low level", "number":"AB237654-CMP16", "productcode":"" }, { "size":"1 x 1 mL", "name":"Control - High level", "number":"AB237654-CMP17", "productcode":"" } ] } } }
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특성 및 보관 정보

배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
+4°C
보관 정보
+4°C
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Rituximab also known as anti-CD20 is a monoclonal antibody that targets the CD20 protein expressed on the surface of B cells. The CD20 protein is a non-glycosylated phosphoprotein with a mass of approximately 33 to 37 kilodaltons. It is expressed in both normal and malignant B cells from the pre-B-cell stage through the mature B-cell stage. The protein is absent in pro-B cells and plasma cells which helps in the specific targeting of B cells without affecting the stem cells or other immune cells.
Biological function summary

Rituximab depletes B cells by inducing cell lysis through mechanisms like antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC). Rituximab’s binding to CD20 leads to B cell apoptosis. As part of the immune system B cells produce antibodies; hence B cell depletion affects humoral immunity. However this depletion allows for the reduction of abnormal B cells in conditions like cancer and autoimmune diseases where aberrant B cell activity plays a harmful role.

Pathways

CD20 does not belong to a multi-component signaling complex but plays a role in calcium signaling in B cells. It modulates calcium influx which is critical for B cell activation and regulation. The pathways involving CD20 are associated with B-cell receptor signaling an essential mechanism regulating B cell survival and proliferation. Other proteins like SYK and BLNK are involved in the extended signaling cascade triggered by B-cell receptor activation.

Rituximab plays an important role in the treatment of B-cell non-Hodgkin lymphomas and rheumatoid arthritis. It targets and removes malignant B cells in lymphoma offering an effective therapy alongside traditional chemotherapies. In rheumatoid arthritis rituximab reduces B cell-mediated inflammation and tissue damage. Rituximab's specificity for CD20 allows it to reduce disease-associated B cells without destroying all B cells minimizing unintended consequences on the immune system.
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제품 프로토콜

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타겟 정보

See full target information Anti-Rituximab
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websiteProtocolBooklet
en
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Product promise

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