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AB88527

Anti-AACT antibody

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Mouse Polyclonal AACT antibody. Carrier free. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human SERPINA3.
2 이미지
Immunocytochemistry/ Immunofluorescence - Anti-AACT antibody (AB88527)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-AACT antibody (AB88527)

ab88527 at 10 μg/ml staining AACT in paraformaldehyde fixed, permeabilised HeLa cells, by immunofluorescence.

Western blot - Anti-AACT antibody (AB88527)
  • WB

Unknown

Western blot - Anti-AACT antibody (AB88527)

All lanes:

Western blot - Anti-AACT antibody (ab88527) at 1 µg/mL

All lanes:

HeLa cell lysate at 50 µg

Predicted band size: 47 kDa

Observed band size: 48 kDa

false

주요 정보

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

Yes

Reacts with

Human

Applications

WB, ICC/IF

applications

Immunogen

Recombinant Full Length Protein corresponding to Human SERPINA3.

P01011

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대체품

Primary Antibodies

AB205198

Anti-AACT antibody [EPR17088-68]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-AACT antibody [EPR17088-68] (AB205198)

  • 0
  • 0
Primary Antibodies

AB180492

Anti-AACT antibody [EPR14117(B)]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AACT antibody [EPR14117(B)] (AB180492)

  • 0
  • 0
Primary Antibodies

AB223542

Anti-AACT antibody [EPR17088-68] - BSA and Azide free

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-AACT antibody [EPR17088-68] - BSA and Azide free (AB223542)

  • 0
  • 0
Primary Antibodies

AB129194

Anti-AACT antibody [EPR5905]

RabMAb|Recombinant

Western blot - Anti-AACT antibody [EPR5905] (AB129194)

  • 1
  • 1
Primary Antibodies

AB232054

Anti-AACT antibody [EPR5905] - BSA and Azide free

RabMAb|Recombinant

Western blot - Anti-AACT antibody [EPR5905] - BSA and Azide free (AB232054)

  • 0
  • 0

보완 제품

Primary Antibodies

AB305035

Anti-YKL-40/CHI3L1 antibody [EPR27396-56]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant

Immunohistochemistry - Anti-YKL-40/CHI3L1 antibody [EPR27396-56] (AB305035)

  • 0
  • 0
Primary Antibodies

AB207303

Anti-alpha 1 Antitrypsin antibody [EPR17087-50]

RabMAb|Recombinant|KO Validated|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-alpha 1 Antitrypsin antibody [EPR17087-50] (AB207303)

  • 4
  • 2
Primary Antibodies

AB183734

Anti-GFP antibody [EPR14104]

RabMAb|Recombinant|Lab Essentials|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GFP antibody [EPR14104] (AB183734)

  • 5
  • 24
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "10 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein A
보관 버퍼
pH: 7.4 Constituents: PBS
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

The target protein Alpha-1-antichymotrypsin (AACT) also known as ACT is a serpin family member with a mass of approximately 68 kDa. This protein functions as an inhibitor of serine proteases particularly targeting chymotrypsin-like enzymes. AACT is expressed in the liver and secreted into the plasma where it carries out its inhibitory role. It is a significant component of the antiprotease shield in human physiology guarding tissues against proteolytic damage.
Biological function summary

Alpha-1-antichymotrypsin plays a role in regulating protease activity to maintain tissue integrity. AACT forms part of a complex that involves other protease inhibitors and enzymes contributing to the balance of protein breakdown and regeneration. Its presence in the extracellular matrix highlights its structural and protective functions supporting cells against enzyme-mediated degradation.

Pathways

Alpha-1-antichymotrypsin takes part in inflammatory and immune response pathways. It interacts within the acute phase response pathway a system activated during inflammatory events. This protein's relationship with other protease inhibitors such as alpha-1-antitrypsin accentuates its role in controlling proteolytic enzymes that could otherwise propagate unchecked inflammation and tissue damage.

Alpha-1-antichymotrypsin associates with neurodegenerative diseases such as Alzheimer's disease and pulmonary disorders. Its elevated levels have been observed in Alzheimer's disease cases where it might participate alongside amyloid-beta precursor protein influencing amyloid plaque formation. In lung-related disorders its collaboration with proteins like elastase can affect tissue breakdown emphasizing its role in maintaining pulmonary health.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2.
See full target information SERPINA3

대체 명칭 보기

AACT, GIG24, GIG25, SERPINA3, Alpha-1-antichymotrypsin, ACT, Cell growth-inhibiting gene 24/25 protein, Serpin A3
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Cellular physiology and biochemistry : internation 34:1701-10 PubMed25401993

2014

Comparative proteomic profile of the human placenta in normal and fetal growth restriction subjects.

Applications

Unspecified application

Species

Unspecified reactive species

Zhijing Miao,Min Chen,Hong Wu,Hongjuan Ding,Zhonghua Shi
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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