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AB235376

Anti-AASDHPPT antibody

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Rabbit Polyclonal AASDHPPT antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human AASDHPPT.

대체 명칭 보기

CGI-80, HAH-P, HSPC223, x0005, AASDHPPT, L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase, 4'-phosphopantetheinyl transferase, Alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase, LYS5 ortholog, AASD-PPT

1 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AASDHPPT antibody (AB235376)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AASDHPPT antibody (AB235376)

Paraffin-embedded human testis tissue stained for AASDHPPT with ab235376 at 1/100 dilution in immunohistochemical analysis.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human AASDHPPT.

Q9NRN7

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보완 제품

Primary Antibodies

AB229111

Anti-OXSM antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-OXSM antibody (AB229111)

  • 0
  • 0
Primary Antibodies

AB187996

Anti-SUCLG2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SUCLG2 antibody (AB187996)

  • 0
  • 0
Primary Antibodies

AB181021

Anti-NDUFAB1 antibody [EPR6725]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NDUFAB1 antibody [EPR6725] (AB181021)

  • 0
  • 0
Primary Antibodies

AB32049

Anti-p53 antibody [Y5]

RabMAb|Recombinant|KO Validated|Lab Essentials|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-p53 antibody [Y5] (AB32049)

  • 4
  • 5
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/200 - 1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Orangutan": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein G
Purification 관련 사항
Purity >95%.
보관 버퍼
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

AASDHPPT also known as L-aminoadipate-semialdehyde dehydrogenase phosphopantetheinyl transferase is a specialized enzyme that catalyzes the transfer of 4'-phosphopantetheine from coenzyme A to holo-acyl carrier protein (ACP) domains. With a molecular mass of approximately 32 kDa AASDHPPT plays an important role in the post-translational modification of ACP domains in lysine biosynthesis. This enzyme expresses in many tissues with strong presence in liver and kidney tissues. Its enzymatic activity is vital for maintaining proper cellular function.
Biological function summary

AASDHPPT functions by participating in the synthesis of lysine through its role as a phosphopantetheinyl transferase enzyme. It is an essential part of the post-translational modification complex that ensures correct functionality of ACP domains involved in metabolic pathways. Through modification of ACP domains AASDHPPT supports the synthesis of important biomolecules essential for metabolic processes. The enzyme's activity has direct impact on the production and availability of lysine an amino acid necessary for protein synthesis and various metabolic functions.

Pathways

AASDHPPT integrates into several critical metabolic pathways prominently the lysine biosynthesis pathway. Additionally its function links closely with fatty acid biosynthesis pathways due to the common role of ACP domains in numerous metabolic transformations. In the context of these pathways AASDHPPT associates with proteins like serine palmitoyltransferase emphasizing its broad role in metabolic regulation and enzyme activation during biosynthetic reactions.

AASDHPPT links to certain metabolic disorders such as familial hyperlysinemia which arises from disruptions in the lysine biosynthesis pathway. Alterations in AASDHPPT activity can affect lysine levels and metabolic balance contributing to this condition. Additionally improper function of this enzyme has indirect connections to metabolic disorders involving the liver as variations in pathway activity can impact liver function. The enzyme interacts with proteins such as alpha-aminoadipic semialdehyde dehydrogenase further illustrating its involvement in a network of metabolic processes and potential disease links.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Catalyzes the post-translational modification of target proteins by phosphopantetheine. Can transfer the 4'-phosphopantetheine moiety from coenzyme A, regardless of whether the CoA is presented in the free thiol form or as an acetyl thioester, to a serine residue of a broad range of acceptors including the acyl carrier domain of FASN.
See full target information AASDHPPT
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Science advances 10:eado3141 PubMed39047111

2024

Atf3-mediated metabolic reprogramming in hepatic macrophage orchestrates metabolic dysfunction-associated steatohepatitis.

Applications

Unspecified application

Species

Unspecified reactive species

Shuwei Hu,Rui Li,Dongxu Gong,Pei Hu,Jitu Xu,Yingjie Ai,Xiaojie Zhao,Chencheng Hu,Minghuan Xu,Chenxi Liu,Shuyu Chen,Jie Fan,Zhonghua Zhao,Zhigang Zhang,Huijuan Wu,Yanyong Xu
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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