Anti-ABCA1 antibody
3
(6 리뷰들)
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(72 제품이 사용된 논문 )
- IHC-P
Supplier Data
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ABCA1 antibody (AB7360)
ab7360, staining ABCA1 in human prostate epithelium showing luminal and membrane staining by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections).
- WB
Unknown
Western blot - Anti-ABCA1 antibody (AB7360)
Detection of ABCA1 in mouse peritoneal macrophages using ab7360. ECL exposure, 1 min.
Lane 4 : T09 uninduced lysate
Lane 5 : T09 induced lysate Detection of ABCA1 in mouse peritoneal macrophages using ab7360. ECL exposure, 1 min.
Lane 4 : T09 uninduced lysate
Lane 5 : T09 induced lysate
All lanes:
Western blot - Anti-ABCA1 antibody (ab7360)
Predicted band size: 254 kDa
false
- WB
Unknown
Western blot - Anti-ABCA1 antibody (AB7360)
All lanes:
Western blot - Anti-ABCA1 antibody (ab7360)
Lane 1:
RAW 264.7 whole cell lysate treated with T0901317 at 25 µg
Lane 2:
RAW 264.7 whole cell lysate untreated at 25 µg
Predicted band size: 254 kDa
false
Reactivity 정보
특성 및 보관 정보
제형
Purification 테크닉
보관 버퍼
배송 시 보관 조건
적절한 단기 보관 기간
적절한 단기 보관 조건
적절한 장기 보관 조건
보관 정보
추가 정보
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
ABCA1 functions as a cholesterol efflux pump in the cellular membrane. It facilitates the transfer of cholesterol to lipid-poor apolipoproteins such as apoA-I which then forms HDL particles. This active process helps maintain cellular cholesterol homeostasis and reduces cholesterol accumulation. ABCA1 is a critical component of the HDL synthesis pathway and does not form part of a larger protein complex acting more as an individual unit in this function.
Pathways
Many regulatory mechanisms control the activity of ABCA1. It plays a significant role in the reverse cholesterol transport pathway thereby promoting the movement of cholesterol away from peripheral tissues back to the liver for excretion. This pathway helps maintain systemic lipid balance. The LXR/RXR pathway regulates ABCA1 expression aligning it closely with other proteins such as LXR and ABCG1 which also deal with cholesterol metabolism.
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제품이 사용된 논문 (72)
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