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AB197406

Anti-ABCB5 antibody

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Rabbit Polyclonal ABCB5 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ATP-binding cassette sub-family B member 5.

대체 명칭 보기

ATP-binding cassette sub-family B member 5, ABCB5 P-gp, P-glycoprotein ABCB5, ABCB5

2 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ABCB5 antibody (AB197406)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ABCB5 antibody (AB197406)

Immunohistochemical analysis of paraffin-embedded human cervical cancer tissue labeling ABCB5 with ab197406 at a 1/10 dilution.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ABCB5 antibody (AB197406)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ABCB5 antibody (AB197406)

Immunohistochemical analysis of paraffin-embedded human renal cancer tissue labeling ABCB5 with ab197406 at a 1/10 dilution.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human ATP-binding cassette sub-family B member 5. The exact immunogen used to generate this antibody is proprietary information.

Q2M3G0

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대체품

Primary Antibodies

AB77549

Anti-ABCB5 antibody

Western blot - Anti-ABCB5 antibody (AB77549)

  • 0
  • 0
Primary Antibodies

AB203120

Anti-ABCB5 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ABCB5 antibody (AB203120)

  • 4
  • 1

보완 제품

Primary Antibodies

AB229193

Anti-BCRP/ABCG2 antibody [EPR21122]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-BCRP/ABCG2 antibody [EPR21122] (AB229193)

  • 0
  • 0
Primary Antibodies

AB52492

Anti-ALDH1A1 antibody [EP1933Y] - C-terminal

RabMAb|Recombinant|KO Validated|20ul selling size

Flow Cytometry (Intracellular) - Anti-ALDH1A1 antibody [EP1933Y] - C-terminal (AB52492)

  • 4
  • 22
Primary Antibodies

AB170904

Anti-P Glycoprotein antibody [EPR10364-57]

20ul selling size|RabMAb|Recombinant|KO Validated

Western blot - Anti-P Glycoprotein antibody [EPR10364-57] (AB170904)

  • 4
  • 12
Primary Antibodies

AB133357

Anti-CD11b antibody [EPR1344]

BOND RX™ Validated|RabMAb|Advanced Validation|Recombinant|Lab Essentials|20ul selling size

Multiplex immunohistochemistry - Anti-CD11b antibody [EPR1344] (AB133357)

  • 4
  • 37
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/10 - 1/50", "IHCP-species-notes": "<p></p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

ABCB5 also known as ATP-binding cassette sub-family B member 5 belongs to the ABC transporter family. This protein functions mechanically as a transmembrane transporter that moves various molecules across cellular membranes using ATP hydrolysis. ABCB5 has a molecular mass of approximately 81 kDa. It is primarily expressed in stem cells melanocytes and certain cancer cells notably in the skin and eye tissues.
Biological function summary

ABCB5 plays an essential role in the regulation of cellular processes including development proliferation and differentiation. It is part of the ATP-binding cassette transporters which help in maintaining cellular homeostasis by exporting toxic substances out of cells. In stem cells ABCB5 maintains the undifferentiated state and protects cells from apoptosis by mediating efflux of drugs contributing to multidrug resistance.

Pathways

ABCB5 interacts with several cellular pathways involved in cell survival and drug resistance. It is closely connected with the Wnt/beta-catenin signaling pathway which regulates cell proliferation and differentiation. ABCB5 also interacts with proteins like P-glycoprotein (ABCB1) as they both participate in similar drug resistance mechanisms affecting therapeutic outcomes in cancer treatment.

Research links ABCB5 to cancer progression and treatment resistance especially in melanoma and colorectal cancer. Its overexpression associates with chemotherapy resistance indicating a need for targeted therapy approaches. In melanoma proteins such as CD133 and ABCB5 together contribute to maintaining cancer stem cell populations which can lead to metastasis and recurrence.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Energy-dependent efflux transporter responsible for decreased drug accumulation in multidrug-resistant cells (PubMed : 12960149, PubMed : 15205344, PubMed : 15899824, PubMed : 22306008). Specifically present in limbal stem cells, where it plays a key role in corneal development and repair (By similarity).
See full target information ATP-binding cassette sub-family B member 5
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Cell journal 24:665-672 PubMed36377216

2022

Long Non-Coding RNA Functions as A Tumor Suppressor in Colorectal Cancer via Modulating The Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Liumin Kang,Jie Sun,Jie Liu,Feng Xu,Qilin Zhu,Xiaohua Shi
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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