AB181865

Anti-ACSM2A antibody [EPR13330-17]

RabMAb
Recombinant
20ul selling size
각 태그의 뜻

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(3 제품이 사용된 논문 )

Rabbit Recombinant Monoclonal ACSM2A antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 3 publications.

대체 명칭 보기

ACSM2, MACS2, ACSM2A, Acyl-CoA synthetase medium-chain family member 2A, Benzoate--CoA ligase, Butyrate--CoA ligase 2A, Butyryl-coenzyme A synthetase 2A, Middle-chain acyl-CoA synthetase 2A

2 이미지

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ACSM2A antibody [EPR13330-17] (AB181865)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ACSM2A antibody [EPR13330-17] (AB181865)

Immunohistochemical analysis of paraffin-embedded Human liver tissue labeling ACSM2A with ab181865 at a 1/50 dilution. Counter stained with hematoxylin.

Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Supplier Data

Western blot - Anti-ACSM2A antibody [EPR13330-17] (AB181865)

All lanes:

Western blot - Anti-ACSM2A antibody [EPR13330-17] (ab181865) at 1/10000 dilution

Lane 1:

Human fetal liver lysate at 20 µg

Lane 2:

Human fetal kidney lysate at 20 µg

Secondary

All lanes:

Western blot - Goat Anti-Rabbit IgG H&L (HRP) (<a href='/ko/products/secondary-antibodies/goat-rabbit-igg-h-l-hrp-ab136636'>ab136636</a>) at 1/500 dilution

Predicted band size: 64 kDa,66 kDa

Observed band size: 64 kDa,80 kDa

true

주요 정보

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR13330-17

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

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제품 세부 정보

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Protein A

보관 버퍼

Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA

배송 시 보관 조건

Conditional Ambient

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

ACSM2A also known as acyl-CoA synthetase medium-chain family member 2A is an enzyme that activates medium-chain fatty acids by converting them into acyl-CoA derivatives. It has a molecular mass of approximately 63 kDa. This enzyme expresses in liver and kidney tissues where it plays a significant role in lipid metabolism by facilitating the utilization of medium-chain fatty acids.

Biological function summary

ACSM2A catalyzes the formation of acyl-CoA from free fatty acids ATP and coenzyme A. It belongs to the acyl-CoA synthetase family which includes enzymes that are essential for fatty acid metabolism. While not explicitly part of a larger enzymatic complex ACSM2A interacts with other members of this family to modulate fatty acid activation and energy production.

Pathways

ACSM2A significantly contributes to beta-oxidation and the fatty acid metabolic process. It works closely with enzymes like CPT1A (carnitine palmitoyltransferase 1A) in the mitochondria to ensure efficient transport and oxidation of fatty acids. In these pathways ACSM2A's activity is vital for maintaining energy balance and regulating lipid levels within the cell.

Mutations or dysregulations of ACSM2A may associate with metabolic conditions such as obesity and diabetes mellitus. Its connection to obesity involves interactions with proteins like PPARα (peroxisome proliferator-activated receptor alpha) which regulates lipid metabolism and energy homeostasis. Altered expressions of ACSM2A can impact these metabolic pathways influencing disease progression.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism (By similarity). Capable of activating medium-chain fatty acids (e.g. butyric (C4) to decanoic (C10) acids), and certain carboxylate-containing xenobiotics, e.g. benzoate (By similarity).

See full target information ACSM2A

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제품이 사용된 논문 (3)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Nature communications 15:2712 PubMed38548729

2024

Bioorthogonal photocatalytic proximity labeling in primary living samples.

Applications

Unspecified application

Species

Unspecified reactive species

Ziqi Liu,Fuhu Guo,Yufan Zhu,Shengnan Qin,Yuchen Hou,Haotian Guo,Feng Lin,Peng R Chen,Xinyuan Fan

American journal of physiology. Renal physiology 319:F603-F611 PubMed32830538

2020

Expression of , a kidney-specific gene, parallels the function and maturation of proximal tubular cells.

Applications

Unspecified application

Species

Unspecified reactive species

Hirofumi Watanabe,Robert L Paxton,Matthew R Tolerico,Vidya K Nagalakshmi,Shinji Tanaka,Mark D Okusa,Shin Goto,Ichiei Narita,Seiji Watanabe,Maria Luisa S Sequeira-Lοpez,R Ariel Gomez

Photodermatology, photoimmunology & photomedicine 36:208-218 PubMed32027411

2020

Role of 904 nm superpulsed laser-mediated photobiomodulation on nitroxidative stress and redox homeostasis in burn wound healing.

Applications

Unspecified application

Species

Unspecified reactive species

Anju Yadav,Saurabh Verma,Gaurav K Keshri,Asheesh Gupta

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-ACSM2A antibody [EPR13330-17]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ACSM2A antibody [EPR13330-17] (AB181865)

Western blot - Anti-ACSM2A antibody [EPR13330-17] (AB181865)

관련 conjugated 항체와 다양한 조성의 항체 (1)

주요 정보

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

대체품

Primary Antibodies

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

제품 세부 정보

특성 및 보관 정보

제형

Purification 테크닉

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 기간

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (3)

Product promise