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AB222967

Anti-ACTR5 antibody

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Rabbit Polyclonal ACTR5 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ACTR5 aa 150-300.

대체 명칭 보기

ARP5, ACTR5, Actin-related protein 5, hARP5, Sarcoma antigen NY-SAR-16

3 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ACTR5 antibody (AB222967)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ACTR5 antibody (AB222967)

Paraffin-embedded human liver tissue stained for ACTR5 using ab222967 at 1/100 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ACTR5 antibody (AB222967)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ACTR5 antibody (AB222967)

Paraffin-embedded human kidney tissue stained for ACTR5 using ab222967 at 1/100 dilution in immunohistochemical analysis.

Immunocytochemistry/ Immunofluorescence - Anti-ACTR5 antibody (AB222967)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-ACTR5 antibody (AB222967)

HepG2 (human liver hepatocellular carcinoma cell line) cells stained for ACTR5 (green) using ab222967 at 1/100 dilution in ICC/IF. Secondary : Alexa Fluor 488® conjugated Goat Anti-Rabbit IgG (H+L).

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human ACTR5 aa 150-300. The exact immunogen used to generate this antibody is proprietary information.

Q9H9F9

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보완 제품

Primary Antibodies

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AKT1 + AKT2 + AKT3 antibody [EPR16798] (AB179463)

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Primary Antibodies

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Primary Antibodies

AB191606

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Immunocytochemistry/ Immunofluorescence - Anti-PI 3 Kinase p85 alpha antibody [EPR18702] (AB191606)

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  • 2
Primary Antibodies

AB278545

Anti- PI 3 Kinase p85 alpha (phospho Y467) + PI3 Kinase p55 (phospho Y199) antibody [PI3KY458-1A11]

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Flow Cytometry - Anti- PI 3 Kinase p85 alpha (phospho Y467) + PI3 Kinase p55 (phospho Y199) antibody [PI3KY458-1A11] (AB278545)

  • 5
  • 1
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein G
Purification 관련 사항
Purity >95%
보관 버퍼
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

ACTR5 also known as ARP5 forms part of the Actin-Related Protein family. This protein plays a role in chromatin remodeling through its involvement in the INO80 complex. Its molecular mass is approximately 38 kDa. ACTR5 expresses in a broad range of tissues indicating its fundamental role in cellular functions and suggesting its importance in diverse biological processes.
Biological function summary

ACTR5 assists in nucleosome repositioning as part of the INO80 chromatin remodeling complex. This complex modifies chromatin structure facilitating access to DNA for transcription replication and repair. ACTR5 helps in regulating gene expression thereby influencing cellular response to environmental signals. Its activity reflects how cells manage genomic functions and maintain genetic integrity across development and differentiation.

Pathways

ACTR5 engages in chromatin remodeling and DNA damage response pathways. Within these pathways ACTR5 associates with proteins like INO80 and YY1 modulating transcriptional regulation. The presence of ACTR5 in the INO80 complex underlines its responsibility in genome stability and transcription representing a link between chromatin dynamics and cellular genome maintenance mechanisms.

ACTR5 alters processes involved in cancer and neurological disorders. The disruption of ACTR5 or associated proteins like INO80 and YY1 can lead to tumorigenesis through impaired genetic regulation and stability. In the nervous system malfunctioning chromatin remodeling mechanisms involving ACTR5 may contribute to neurodevelopmental disorders. Consequently ACTR5 provides a meaningful target in understanding pathological states linked to chromatin and gene regulation abnormalities.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Involved in DNA double-strand break repair and UV-damage excision repair.
See full target information ACTR5
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

mAbs 8:454-67 PubMed26854859

2016

Inhibition of CD73 AMP hydrolysis by a therapeutic antibody with a dual, non-competitive mechanism of action.

Applications

Unspecified application

Species

Unspecified reactive species

James C Geoghegan,Gundo Diedrich,Xiaojun Lu,Kim Rosenthal,Kris F Sachsenmeier,Herren Wu,William F Dall'Acqua,Melissa M Damschroder
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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