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AB203102

Anti-ADAMTS12 antibody

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(4 제품이 사용된 논문 )

Rabbit Polyclonal ADAMTS12 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human ADAMTS12 aa 300-400 conjugated to Keyhole Limpet Haemocyanin.

대체 명칭 보기

UNQ1918/PRO4389, ADAMTS12, A disintegrin and metalloproteinase with thrombospondin motifs 12, ADAM-TS 12, ADAM-TS12, ADAMTS-12

2 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ADAMTS12 antibody (AB203102)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ADAMTS12 antibody (AB203102)

Immunohistochemical analysis of formalin-fixed, paraffin embedded Human lung carcinoma tissue labeling ADAMTS12 with ab203102 at 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ADAMTS12 antibody (AB203102)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ADAMTS12 antibody (AB203102)

Immunohistochemical analysis of formalin-fixed, paraffin embedded Human colon carcinoma tissue labeling ADAMTS12 with ab203102 at 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human ADAMTS12 aa 300-400 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

P58397

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대체품

Primary Antibodies

AB45041

Anti-ADAMTS12 antibody

Western blot - Anti-ADAMTS12 antibody (AB45041)

  • 0
  • 0

보완 제품

Primary Antibodies

AB52915

Anti-MMP3 antibody [EP1186Y]

20ul selling size|KO Validated|RabMAb|Recombinant

Western blot - Anti-MMP3 antibody [EP1186Y] (AB52915)

  • 5
  • 4
Primary Antibodies

AB5103

Anti-Histone H3 (citrulline R2 + R8 + R17) antibody

Western blot - Anti-Histone H3 (citrulline R2 + R8 + R17) antibody (AB5103)

  • 4
  • 28
Primary Antibodies

AB46010

Anti-CXCL14 antibody

Sandwich ELISA - Anti-CXCL14 antibody (AB46010)

  • 0
  • 0
Primary Antibodies

AB80194

Anti-Transferrin Receptor 2/TFR2 antibody

BOND RX™ Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Transferrin Receptor 2/TFR2 antibody (AB80194)

  • 4
  • 32
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p>(or 1/50 - 1/200 using a fluorescent secondary antibody).</p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein A
보관 버퍼
pH: 7.4 Preservative: 0.02% Proclin 300 Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

ADAMTS12 also recognized as A Disintegrin and Metalloproteinase with Thrombospondin Motifs 12 is a member of the ADAMTS family. It is a secreted enzyme with a mass of approximately 204 kDa. This protease is involved in extracellular matrix remodelling. The expression of ADAMTS12 occurs mainly in placental tissue and at lower levels in various other tissues including the lung and heart. It plays a role in processing protein substrates in the extracellular environment.
Biological function summary

The interactions with other matrix components allow ADAMTS12 to mediate matrix organization and degradation. It does not form part of a larger protein complex on its own but interacts with extracellular matrix proteins like aggrecan and versican. These interactions facilitate the breakdown of large proteoglycans aiding tissue morphogenesis and repair.

Pathways

ADAMTS12 participates in the extracellular matrix organization and degradation pathways. These pathways involve proteins such as aggrecanase and versicanase which ADAMTS12 closely relates to through its proteolytic activity. It plays a significant role in matrix remodelling which is essential for cellular migration and differentiation processes.

Alterations in ADAMTS12 expression link to osteoarthritis and cancer. In osteoarthritis increased ADAMTS12 activity contributes to cartilage degradation. In cancer its expression modifies cellular environments influencing tumor progression. It also interacts with matrix proteins like aggrecan in osteoarthritis and demonstrates associations with cancer-related proteins contributing to disease pathology.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Metalloprotease that may play a role in the degradation of COMP. Also cleaves alpha-2 macroglobulin and aggregan. Has anti-tumorigenic properties.
See full target information ADAMTS12
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제품이 사용된 논문 (4)

Recent publications for all applications. Explore the 전체 목록 and refine your search

African health sciences 22:56-63 PubMed37092087

2023

MicroRNA-186 suppresses cell proliferation and metastasis in bladder cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Jun Feng Liang,Pei Hua Li,Yong Zhu,Shuai Shuai Zheng,Jing Wei Liu,Shi Qiang Song

Frontiers in oncology 12:849717 PubMed35280819

2022

An Integrated Pan-Cancer Analysis of ADAMTS12 and Its Potential Implications in Pancreatic Adenocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Caiyun Song,Jionghuang Chen,Chaolei Zhang,Dapeng Dong

Cancer cell international 22:21 PubMed35033072

2022

Development and validation of a novel 3-gene prognostic model for pancreatic adenocarcinoma based on ferroptosis-related genes.

Applications

Unspecified application

Species

Unspecified reactive species

Jihua Yang,XiaoHong Wei,Fang Hu,Wei Dong,Liao Sun

Journal of molecular endocrinology 64:155-164 PubMed31958317

2020

Glucocorticoid signalling drives reduced versican levels in the fetal mouse lung.

Applications

Unspecified application

Species

Unspecified reactive species

Kelly L Short,A Daniel Bird,Bennet K L Seow,Judy Ng,Annie R A McDougall,Megan J Wallace,Stuart B Hooper,Timothy J Cole
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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