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AB235341

Anti-ADAT1 antibody

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Rabbit Polyclonal ADAT1 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ADAT1 aa 1 to C-terminus.

대체 명칭 보기

tRNA-specific adenosine deaminase 1, hADAT1, tRNA-specific adenosine-37 deaminase, ADAT1

2 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ADAT1 antibody (AB235341)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ADAT1 antibody (AB235341)

Paraffin-embedded human skin tissue stained for ADAT1 with ab235341 at 1/100 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ADAT1 antibody (AB235341)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ADAT1 antibody (AB235341)

Paraffin-embedded human tonsil tissue stained for ADAT1 with ab235341 at 1/100 dilution in immunohistochemical analysis.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human ADAT1 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9BUB4

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대체품

Primary Antibodies

AB122662

Anti-ADAT1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ADAT1 antibody (AB122662)

  • 0
  • 0

보완 제품

Primary Antibodies

AB126745

Anti-ADAR1 antibody [EPR7033]

RabMAb|Recombinant|KO Validated|20ul selling size

Flow Cytometry (Intracellular) - Anti-ADAR1 antibody [EPR7033] (AB126745)

  • 0
  • 0
Primary Antibodies

AB247642

Anti-ADA antibody [EPR4438] - BSA and Azide free

RabMAb|Recombinant

Western blot - Anti-ADA antibody [EPR4438] - BSA and Azide free (AB247642)

  • 0
  • 0
Primary Antibodies

AB122280

Anti-ADAT2 antibody

Immunocytochemistry - Anti-ADAT2 antibody (AB122280)

  • 3
  • 2
Primary Antibodies

AB109363

Anti-RENT1/hUPF1 antibody [EPR4681]

20ul selling size|RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-RENT1/hUPF1 antibody [EPR4681] (AB109363)

  • 5
  • 2
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cynomolgus monkey": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein G
Purification 관련 사항
Purity >95%.
보관 버퍼
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

ADAT1 also known as ADAT one or Adenosine Deaminase Acting on tRNA 1 is an enzyme that catalyzes the deamination of adenosine to inosine in transfer RNAs. This enzyme is critical for the proper modification of tRNA ensuring accurate protein synthesis. ADAT1 is composed of approximately 55 kDa polypeptides and is expressed in various tissues with notably higher levels in the testes and brain. It modifies tRNA anticodons which are necessary for precise translation of the genetic code.
Biological function summary

The function of tRNA modification by ADAT1 impacts protein translation accuracy and efficiency. It is a part of a larger complex involving other tRNA-modifying enzymes. Proper functioning of ADAT1 is necessary to maintain the integrity of protein synthesis as it impacts the decoding of genetic information during translation by tRNA. This process helps cells to correctly read the mRNA sequences and modify the protein expression accordingly.

Pathways

TRNA modification by ADAT1 plays an important role in the protein synthesis pathway. This modification enhances the fidelity and efficiency of translating genetic information from mRNA into functional proteins. The enzyme works closely with other tRNA modification enzymes such as ADAT2 and ADAT3 which are involved in post-transcriptional modification of tRNA. These interactions ensure that tRNAs have the correct structure and function to support normal cell physiology.

Malfunction of ADAT1 is associated with neurological disorders and some types of cancer. This is due to the enzyme's role in maintaining protein synthesis fidelity which can affect cellular health. Abnormal activity or expression of ADAT1 could disrupt protein balance in cells linking it to disorders like intellectual disability and certain cancers. The reduced function of ADAT1 affects its interaction with other proteins like ADAR which are involved in RNA editing and are important for normal cellular processes.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Specifically deaminates adenosine-37 to inosine in tRNA-Ala.
See full target information ADAT1
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

The EMBO journal 40:e106336 PubMed33595114

2021

NHP2 downregulation counteracts hTR-mediated activation of the DNA damage response at ALT telomeres.

Applications

Unspecified application

Species

Unspecified reactive species

Maya Raghunandan,Dan Geelen,Eva Majerova,Anabelle Decottignies
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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