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AB111903

Anti-Adenosyl Homocysteine antibody [EPR4499]

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Rabbit Recombinant Monoclonal Adenosyl Homocysteine antibody. Suitable for cELISA and reacts with Modified Amino Acid samples. Cited in 1 publication.
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Competitive ELISA - Anti-Adenosyl Homocysteine antibody [EPR4499] (AB111903)
  • cELISA

Unknown

Competitive ELISA - Anti-Adenosyl Homocysteine antibody [EPR4499] (AB111903)

Competitive ELISA : 0.1 μg/ml of BSA-S-adenosylhomocysteine was coated into 96 wells. Serial dilution of S-adenosylhomocysteine (SAH), SAMe, et al. and 0.05 μg/ml of ab111903 were added. HRP conjugated Goat anti-Rabbit IgG antibody was used to develop the color.

관련 conjugated 항체와 다양한 조성의 항체 (1)

  • Carrier free

    Anti-Adenosyl Homocysteine antibody [EPR4499] - BSA and Azide free

주요 정보

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR4499

Isotype

IgG

Carrier free

No

Applications

cELISA

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

Specificity

This antibody shows the following reactivities with related compounds:S-(5'-Adenosyl)-L-homocysteine: 100%S-(5'-Adenosyl)-L-methionine: 0%Adenosine: 4.4%Homocysteine: 4.4%Cystathionine: 0%L-Cysteine: 1.5%Glutathione: 1.8%

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보완 제품

Primary Antibodies

AB230151

Anti-BHMT + BHMT2 antibody [EPR20822] - BSA and Azide free

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-BHMT + BHMT2 antibody [EPR20822] - BSA and Azide free (AB230151)

  • 0
  • 0
Primary Antibodies

AB134966

Anti-SAHH antibody [EPR9261]

RabMAb|Recombinant

Western blot - Anti-SAHH antibody [EPR9261] (AB134966)

  • 0
  • 0
Primary Antibodies

AB37266

Anti-Giantin antibody [9B6] - Golgi Marker

Lab Essentials

Immunocytochemistry/ Immunofluorescence - Anti-Giantin antibody [9B6] - Golgi Marker (AB37266)

  • 4
  • 15
Primary Antibodies

AB133497

Anti-Flotillin 1 antibody [EPR6041]

RabMAb|Recombinant|KO Validated|20ul selling size

Flow Cytometry (Intracellular) - Anti-Flotillin 1 antibody [EPR6041] (AB133497)

  • 5
  • 6
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "cELISA" : {"fullname" : "Competitive ELISA", "shortname":"cELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Modified Amino Acid": { "cELISA-species-checked": "testedAndGuaranteed", "cELISA-species-dilution-info": "1/5000", "cELISA-species-notes": "<p></p>" } } }
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제품 세부 정보

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein A
보관 버퍼
pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
배송 시 보관 조건
Conditional Ambient
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
보관 정보
Stable for 12 months at -20°C
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Adenosyl Homocysteine is a critical intermediate in the biological process known as the methionine cycle. It is also referred to as S-Adenosylhomocysteine (SAH) with a molecular mass of approximately 384.46 g/mol. This compound forms as a by-product of methylation reactions after the methyl group transfer from S-Adenosylmethionine (SAM). Adenosyl Homocysteine hydrolase further processes it into homocysteine and adenosine. Expression of Adenosyl Homocysteine is ubiquitous occurring across various cell types and tissues in the body.
Biological function summary

Adenosyl homocysteine plays an important role in regulating methylation processes which are essential for various cellular functions like epigenetic modifications and gene expression regulation. It forms part of a complex network where it acts as a metabolic regulator. By inhibiting methyltransferase enzymes it directly controls the levels of SAM affecting the methylation status in cells. As a feedback inhibitor Adenosyl Homocysteine balances methyl group transfers critical for cellular function.

Pathways

Adenosyl homocysteine sits at the intersection of the methionine and homocysteine metabolic pathways. It maintains a delicate balance necessary for transmethylation reactions. The methionine cycle and homocysteine metabolism pathways are linked by this compound. Adenosyl Homocysteine connects with other proteins such as S-Adenosylhomocysteine hydrolase and methionine synthase which are important for transferring methyl groups important for cellular processes.

Disruptions in Adenosyl Homocysteine levels contribute to conditions like cardiovascular diseases and hyperhomocysteinemia. Elevated levels of homocysteine resulting from inefficient conversion of Adenosyl Homocysteine are associated with these disorders. Within these diseases adenosyl homocysteine relates to proteins like homocysteine methyltransferase that influence methionine metabolism. The imbalance involves increased risk factors for vascular diseases establishing Adenosyl Homocysteine as a target for therapeutic intervention and research.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

See full target information Adenosyl Homocysteine

대체 명칭 보기

S (5' Adenosyl) L homocysteine, S Adenosyl L homocysteine, S adenosylhomocysteine, SAH
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Molecules (Basel, Switzerland) 18:13020-6 PubMed24145794

2013

Selection of a mimotope peptide of S-adenosyl-L-homocysteine and its application in immunoassays.

Applications

ELISA

Species

Unspecified reactive species

Chun Wu,George Tzertzinis
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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