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AB236767

Anti-ADH7 antibody

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Rabbit Polyclonal ADH7 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human ADH7.

대체 명칭 보기

All-trans-retinol dehydrogenase [NAD(+)] ADH7, Alcohol dehydrogenase class 4 mu/sigma chain, Alcohol dehydrogenase class IV mu/sigma chain, Gastric alcohol dehydrogenase, Omega-hydroxydecanoate dehydrogenase ADH7, Retinol dehydrogenase, ADH7

3 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ADH7 antibody (AB236767)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ADH7 antibody (AB236767)

Paraffin-embedded human lung tissue stained for ADH7 with ab236767 at 1/100 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ADH7 antibody (AB236767)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ADH7 antibody (AB236767)

Paraffin-embedded human gastric cancer tissue stained for ADH7 with ab236767 at 1/100 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ADH7 antibody (AB236767)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ADH7 antibody (AB236767)

Paraffin-embedded human lung cancer tissue stained for ADH7 with ab236767 at 1/100 dilution in immunohistochemical analysis.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human ADH7.

P40394

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대체품

Primary Antibodies

AB186408

Anti-ADH7 antibody [EPR13949]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-ADH7 antibody [EPR13949] (AB186408)

  • 5
  • 2

보완 제품

Primary Antibodies

AB194697

Anti-UGT1A1 antibody

Western blot - Anti-UGT1A1 antibody (AB194697)

  • 4
  • 2
Primary Antibodies

AB76976

Anti-ALDH3A1 antibody

Western blot - Anti-ALDH3A1 antibody (AB76976)

  • 0
  • 0
Primary Antibodies

AB6326

Anti-BrdU antibody [BU1/75 (ICR1)] - Proliferation Marker

Flow Cytometry (Intracellular) - Anti-BrdU antibody [BU1/75 (ICR1)] - Proliferation Marker (AB6326)

  • 5
  • 104
Primary Antibodies

AB16667

Anti-Ki67 antibody [SP6]

BOND RX™ Validated|KO Validated|RabMAb|Advanced Validation|Recombinant|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ki67 antibody [SP6] (AB16667)

  • 5
  • 133
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein G
Purification 관련 사항
Purity >95%
보관 버퍼
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

The biological target ADH7 also known as alcohol dehydrogenase 7 or class IV ADH is an enzyme with a molecular mass of approximately 38 kDa. ADH7 belongs to the alcohol dehydrogenase family and participates in the oxidative reduction of alcohols to aldehydes or ketones. This enzyme is expressed mainly in the stomach and to a lesser extent in the liver and other tissues. The expression levels depend on genetic variation among different populations.
Biological function summary

ADH7 plays a role in metabolizing retinoids and ethanol in the body. It does not form a complex but acts as a monomer in enzymatic reactions. By converting alcohols to their aldehyde forms ADH7 participates in detoxification processes and helps maintain homeostasis of retinoid metabolites. This function involves the interaction of ADH7 with other alcohol dehydrogenases that process overlapping substrate types.

Pathways

ADH7 is involved in the retinol metabolism pathway and ethanol degradation pathway. In the retinol metabolism pathway it works alongside other enzymes such as retinol dehydrogenase to maintain vitamin A homeostasis. These pathways are important for detoxifying alcohols and maintaining cell signaling processes. Through some metabolic connections ADH7 interacts with proteins like CYP2E1 in ethanol degradation highlighting a collaborative yet distinct pathway environment.

ADH7 shows a connection to alcoholism and gastric cancer. Genetic variations in ADH7 may influence individual susceptibility to alcohol dependence due to altered alcohol metabolism. Additionally owing to its presence in gastric tissues ADH7's interaction with aldehyde dehydrogenase can modulate the development of gastric cancer under certain conditions emphasizing its relevance in disease etiology and potential therapeutic exploration.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Catalyzes the NAD-dependent oxidation of all-trans-retinol, alcohol, and omega-hydroxy fatty acids and their derivatives (PubMed : 15369820, PubMed : 16787387, PubMed : 9600267). Oxidizes preferentially all trans-retinol, all-trans-4-hydroxyretinol, 9-cis-retinol, 2-hexenol, and long chain omega-hydroxy fatty acids such as juniperic acid (PubMed : 15369820, PubMed : 16787387, PubMed : 9600267). In vitro can also catalyze the NADH-dependent reduction of all-trans-retinal and aldehydes and their derivatives (PubMed : 15369820, PubMed : 16787387, PubMed : 9600267). Reduces preferentially all trans-retinal, all-trans-4-oxoretinal and hexanal (PubMed : 15369820, PubMed : 16787387). Catalyzes in the oxidative direction with higher efficiency (PubMed : 15369820, PubMed : 16787387). Therefore may participate in retinoid metabolism, fatty acid omega-oxidation, and elimination of cytotoxic aldehydes produced by lipid peroxidation (PubMed : 15369820, PubMed : 16787387, PubMed : 9600267).
See full target information ADH7
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

International journal of general medicine 17:3673-3687 PubMed39206267

2024

Phosphoglycerate Dehydrogenase Overexpression Inhibits Ferroptosis to Repress Calcification of Human Coronary Artery Vascular Smooth Muscle Cells via the P53/SLC7A11 Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Yuhai Zou,Dongdong Li,Ge Guan,Wenting Liu
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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