AB151727

Anti-ADRA2B antibody [EPR9623]

RabMAb
Recombinant
각 태그의 뜻

Be the first to review this product! 리뷰 제출

(12 제품이 사용된 논문 )

Rabbit Recombinant Monoclonal ADRA2B antibody. Suitable for WB and reacts with Human samples. Cited in 12 publications.

대체 명칭 보기

ADRA2L1, ADRA2RL1, ADRA2B, Alpha-2B adrenergic receptor, Alpha-2 adrenergic receptor subtype C2, Alpha-2B adrenoreceptor, Alpha-2B adrenoceptor, Alpha-2BAR

1 이미지

Unknown

Western blot - Anti-ADRA2B antibody [EPR9623] (AB151727)

All lanes:

Western blot - Anti-ADRA2B antibody [EPR9623] (ab151727) at 1/10000 dilution

Lane 1:

Human fetal brain lysate at 10 µg

Lane 2:

MCF7 cell lysate at 10 µg

Lane 3:

HepG2 cell lysate at 10 µg

Lane 4:

293T cell lysate at 10 µg

Secondary

All lanes:

Goat anti-rabbit HRP at 1/2000 dilution

Predicted band size: 50 kDa

false

주요 정보

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR9623

Isotype

IgG

Carrier free

Reacts with

Human

Applications

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

style

left-column

style

left-column

Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "1/10 - 1/100", "FlowCyt-species-notes": "<a href='/ko/products/primary-antibodies/rabbit-igg-monoclonal-epr25a-isotype-control-ab172730'>ab172730</a> - Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/10000 - 1/50000", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Mouse": { "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

style

left-column

제품 세부 정보

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

style

left-column

특성 및 보관 정보

제형

Liquid

보관 버퍼

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA

배송 시 보관 조건

Conditional Ambient

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

style

left-column

추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

ADRA2B also known as alpha-2B adrenergic receptor is a G protein-coupled receptor with an approximate mass of 50 kDa. It is specifically involved in the regulation of neurotransmitter release playing a critical role in the sympathetic nervous system. The receptor is expressed in several tissues including the brain heart and lungs. It has a high affinity for catecholamines and by binding to these ligands ADRA2B modulates various physiological processes.

Biological function summary

The alpha-2B adrenergic receptor is involved in mediating vasoconstriction and neurotransmission. This receptor is part of a larger complex of adrenergic receptors which includes alpha-2A and alpha-2C subtypes. Through its activity ADRA2B influences cardiovascular functions by controlling blood vessel tone and cardiac output. The receptor also plays roles in the central nervous system by affecting neurotransmitter release which impacts stress and arousal responses.

Pathways

The alpha-2B adrenergic receptor participates in the adrenergic signaling pathway influencing cardiovascular and nervous system activities. In this pathway it is associated with G protein interactions leading to inhibition of adenylate cyclase and reduction of cAMP levels. ADRA2B also interacts with proteins such as Giα subunits which further disseminate signals involved in the regulation of physiological responses like heart rate and vascular resistance.

The alpha-2B adrenergic receptor has links with cardiovascular diseases and psychiatric disorders. Dysregulation or mutations in ADRA2B may contribute to conditions like hypertension by affecting vasoconstriction and cardiovascular stability. Additionally alterations in receptor function could relate to mood disorders such as depression due to its role in neurotransmitter regulation. ADRA2B interacts with other adrenergic receptors and neurotransmitter systems influencing the pathophysiology of these diseases.

style

left-column

style

left-column

제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

style

left-column

타겟 정보

Alpha-2 adrenergic receptors are G protein-coupled receptors for catecholamines that activate G(i/o) protein pathway, thereby promoting adenylyl cyclase inhibition, ERK1/2 stimulation, and voltage-gated calcium channels suppression (PubMed : 11056163, PubMed : 2164221, PubMed : 2172775, PubMed : 23105096, PubMed : 26811329). Control a variety of physiological processes, such as regulation of blood pressure, lipolysis and insulin release (PubMed : 2164221). The rank order of potency for agonists of ADRA2B is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol > propanolol > pindolol (PubMed : 2164221, PubMed : 2172775).

See full target information ADRA2B

style

left-column

제품이 사용된 논문 (12)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Science translational medicine 16:eadg3665 PubMed38478631

2024

Cortical hyperexcitability in mouse models and patients with amyotrophic lateral sclerosis is linked to noradrenaline deficiency.

Applications

Unspecified application

Species

Unspecified reactive species

Jelena Scekic-Zahirovic,Cristina Benetton,Aurore Brunet,XiaoQian Ye,Evgeny Logunov,Vincent Douchamps,Salim Megat,Virginie Andry,Vanessa Wing Yin Kan,Geoffrey Stuart-Lopez,Johan Gilet,Simon J Guillot,Sylvie Dirrig-Grosch,Charlotte Gorin,Margaux Trombini,Stéphane Dieterle,Jérôme Sinniger,Mathieu Fischer,Frédérique René,Zeynep Gunes,Pascal Kessler,Luc Dupuis,Pierre-François Pradat,Yannick Goumon,Romain Goutagny,Véronique Marchand-Pauvert,Sabine Liebscher,Caroline Rouaux

The Journal of endocrinology 248:277-288 PubMed33434145

2021

Norepinephrine exposure restrains endometrial decidualization during early pregnancy.

Applications

Unspecified application

Species

Unspecified reactive species

Jiju Wang,Yunhui Tang,Songcun Wang,Liyuan Cui,Dajin Li,Meirong Du

Archives of biochemistry and biophysics 674:108109 PubMed31541620

2019

Upregulation of α2-adrenoceptor synthesis in SHR cardiomyocytes: Recompense without sense - Increased amounts, impaired commands.

Applications

Unspecified application

Species

Unspecified reactive species

Yury M Kokoz,Edward V Evdokimovskii,Alexander V Maltsev

Biochemical and biophysical research communication 512:908-913 PubMed30929926

2019

α2-Adrenoceptor signaling in cardiomyocytes of spontaneously hypertensive rats starts to impair already at early age.

Applications

Unspecified application

Species

Unspecified reactive species

A V Maltsev,E V Evdokimovskii,Y M Kokoz

International journal of molecular sciences 19: PubMed30469522

2018

Noradrenaline Sensitivity Is Severely Impaired in Immortalized Adipose-Derived Mesenchymal Stem Cell Line.

Applications

Unspecified application

Species

Unspecified reactive species

Pyotr A Tyurin-Kuzmin,Vadim I Chechekhin,Anastasiya M Ivanova,Daniyar T Dyikanov,Veronika Y Sysoeva,Natalia I Kalinina,Vsevolod A Tkachuk

Scientific data 5:180196 PubMed30277480

2018

Flow cytometry analysis of adrenoceptors expression in human adipose-derived mesenchymal stem/stromal cells.

Applications

Unspecified application

Species

Unspecified reactive species

Pyotr A Tyurin-Kuzmin,Daniyar T Dyikanov,Julia I Fadeeva,Veronika Yu Sysoeva,Natalia I Kalinina

Nature communications 9:2067 PubMed29802242

2018

Testosterone is an endogenous regulator of BAFF and splenic B cell number.

Applications

Unspecified application

Species

Unspecified reactive species

Anna S Wilhelmson,Marta Lantero Rodriguez,Alexandra Stubelius,Per Fogelstrand,Inger Johansson,Matthew B Buechler,Steve Lianoglou,Varun N Kapoor,Maria E Johansson,Johan B Fagman,Amanda Duhlin,Prabhanshu Tripathi,Alessandro Camponeschi,Bo T Porse,Antonius G Rolink,Hans Nissbrandt,Shannon J Turley,Hans Carlsten,Inga-Lill Mårtensson,Mikael C I Karlsson,Åsa Tivesten

Genes, brain, and behavior 18:e12458 PubMed29341465

2018

P2Y deficiency in mouse impairs noradrenergic system in brain, and alters anxiety-like neurobehavior and memory.

Applications

Unspecified application

Species

Unspecified reactive species

F Zheng,Q Zhou,Y Cao,H Shi,H Wu,B Zhang,F Huang,X Wu

International journal of molecular medicine 41:2328-2338 PubMed29328437

2018

Reduced mitochondrial response sensitivity is involved in the anti‑apoptotic effect of dexmedetomidine pretreatment in cardiomyocytes.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaojian Weng,Xiaodan Zhang,Xiaofei Lu,Jin Wu,Shitong Li

Scientific reports 6:32835 PubMed27596381

2016

Activation of β-adrenergic receptors is required for elevated α1A-adrenoreceptors expression and signaling in mesenchymal stromal cells.

Applications

Flow Cyt

Species

Unspecified reactive species

Pyotr A Tyurin-Kuzmin,Julia I Fadeeva,Margarita A Kanareikina,Natalia I Kalinina,Veronika Yu Sysoeva,Daniyar T Dyikanov,Dmitriy V Stambolsky,Vsevolod A Tkachuk

제품이 사용된 논문 모두 보기

style

left-column

style

left-column

style

right-column

Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-ADRA2B antibody [EPR9623]

Western blot - Anti-ADRA2B antibody [EPR9623] (AB151727)

관련 conjugated 항체와 다양한 조성의 항체 (1)

주요 정보

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

제품 세부 정보

특성 및 보관 정보

제형

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 조건

적절한 장기 보관 조건

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (12)

Product promise