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AB122800

Anti-Adropin antibody

5

(1 리뷰)

|

(4 제품이 사용된 논문 )

Rabbit Polyclonal Adropin antibody. Suitable for IHC-P and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ENHO.

대체 명칭 보기

C9orf165, UNQ470/PRO830, ENHO, Adropin, Energy homeostasis-associated protein

4 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Adropin antibody (AB122800)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Adropin antibody (AB122800)

ab122800, at 1/200 dilution, staining Adropin in Paraffin-embedded Human liver tissue by Immunohistochemistry showing cytoplasmic staining in hepatocytes.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Adropin antibody (AB122800)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Adropin antibody (AB122800)

ab122800, at 1/200 dilution, staining Adropin in Paraffin-embedded Human lung tissue by Immunohistochemistry showing cytoplasmic staining in pneumocytes.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Adropin antibody (AB122800)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Adropin antibody (AB122800)

ab122800, at 1/200 dilution, staining Adropin in Paraffin-embedded Human kidney tissue by Immunohistochemistry showing cytoplasmic staining of tubules and glomeruli.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Adropin antibody (AB122800)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Adropin antibody (AB122800)

ab122800, at 1/200 dilution, staining Adropin in Paraffin-embedded Human cerebral cortex by Immunohistochemistry showing cytoplasmic staining in neuronal cells and neuropil.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human ENHO. The exact immunogen used to generate this antibody is proprietary information.

Q6UWT2

Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }

특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle

추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Adropin is a secreted peptide hormone also known as Energy Homeostasis Associated (ENHO) gene product. This protein has a mass of approximately 4.5 kDa and is primarily expressed in the liver and brain but also in the pancreas and various peripheral tissues. Adropin plays a role in regulating metabolic homeostasis influencing lipid metabolism and glucose levels through its action. It facilitates communication within cells to maintain energy balance and research shows its involvement in modulating insulin sensitivity.
Biological function summary

Adropin influences glucose homeostasis and fatty acid metabolism. It does not form part of a larger complex but functions as a solitary signaling molecule. The protein impacts cellular processes by increasing glucose oxidation and reducing fatty acid oxidation contributing to energy balance. Studies have demonstrated its role in influencing cardiovascular functions and central nervous systems processes which link it to various metabolic conditions.

Pathways

Adropin is involved in the regulation of energy balance through the insulin signaling pathway and the AMPK pathway. Both pathways help manage glucose uptake and energy expenditure. In the insulin signaling pathway adropin works alongside other proteins like PPARγ and GLUT4 to control glucose levels. Adropin's role in the AMPK pathway relates to cellular energy charge and helps maintain metabolic health by modulating lipid and glucose metabolism.

Adropin has potential links to obesity and type 2 diabetes where it might contribute to pathophysiologies. Its reduced levels are often observed in patients with these conditions. The association to disorders involves interaction with proteins such as insulin receptor substrate (IRS) and adiponectin which mediate metabolic responses affecting glucose and lipid homeostasis. Understanding adropin's actions in these contexts could assist in the development of novel therapeutic strategies targeting metabolic disorders.

제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

타겟 정보

Involved in the regulation of glucose homeostasis and lipid metabolism.
See full target information ENHO

제품이 사용된 논문 (4)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Journal of the American Heart Association 10:e020641 PubMed33938228

2021

Aerobic Exercise Restores Aging-Associated Reductions in Arterial Adropin Levels and Improves Adropin-Induced Nitric Oxide-Dependent Vasorelaxation.

Applications

Unspecified application

Species

Unspecified reactive species

Shumpei Fujie,Natsuki Hasegawa,Naoki Horii,Masataka Uchida,Kiyoshi Sanada,Takafumi Hamaoka,Jaume Padilla,Luis A Martinez-Lemus,Seiji Maeda,Motoyuki Iemitsu

Endocrinology 159:994-1004 PubMed29244071

2017

The Glycosyltransferase EOGT Regulates Adropin Expression in Decidualizing Human Endometrium.

Applications

Unspecified application

Species

Unspecified reactive species

Joanne Muter,Mohammad T Alam,Pavle Vrljicak,Flavio S V Barros,Peter T Ruane,Lauren J Ewington,John D Aplin,Melissa Westwood,Jan J Brosens

Biotechnic & histochemistry : official publication 89:104-10 PubMed23957703

2013

Immunohistochemical expressions of adropin and ınducible nitric oxide synthase in renal tissues of rats with streptozotocin-ınduced experimental diabetes.

Applications

Unspecified application

Species

Unspecified reactive species

T Kuloglu,S Aydin

Molecular and cellular biochemistry 380:73-81 PubMed23620340

2013

Expression of adropin in rat brain, cerebellum, kidneys, heart, liver, and pancreas in streptozotocin-induced diabetes.

Applications

Unspecified application

Species

Unspecified reactive species

Suleyman Aydin,Tuncay Kuloglu,Suna Aydin,Mehmet Nesimi Eren,Musa Yilmaz,Mehmet Kalayci,Ibrahim Sahin,Nevin Kocaman,Cihan Citil,Yalcin Kendir
제품이 사용된 논문 모두 보기

Product promise

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