JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB235778

Anti-AGBL2 antibody

Be the first to review this product! 리뷰 제출

|

(1 출판물)

Rabbit Polyclonal AGBL2 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human AGBL2 aa 1-300.

대체 명칭 보기

CCP2, AGBL2, Cytosolic carboxypeptidase 2, ATP/GTP-binding protein-like 2, Protein deglutamylase CCP2

2 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AGBL2 antibody (AB235778)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AGBL2 antibody (AB235778)

Paraffin-embedded human breast cancer tissue stained for AGBL2 using ab235778 at 1/100 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AGBL2 antibody (AB235778)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AGBL2 antibody (AB235778)

Paraffin-embedded human colon cancer tissue stained for AGBL2 using ab235778 at 1/100 dilution in immunohistochemical analysis.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human AGBL2 aa 1-300. The exact immunogen used to generate this antibody is proprietary information.

Q5U5Z8

style
left-column

보완 제품

Primary Antibodies

AB181602

Anti-GAPDH antibody [EPR16891] - Loading Control

RabMAb|Recombinant|Lab Essentials|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GAPDH antibody [EPR16891] - Loading Control (AB181602)

  • 5
  • 23
Primary Antibodies

AB11317

Anti-gamma Tubulin antibody - Centrosome Marker

Immunocytochemistry/ Immunofluorescence - Anti-gamma Tubulin antibody - Centrosome Marker (AB11317)

  • 4
  • 16
Primary Antibodies

AB8295

Anti-Cardiac Troponin T antibody [1C11]

Immunocytochemistry - Anti-Cardiac Troponin T antibody [1C11] (AB8295)

  • 4
  • 15
Primary Antibodies

AB111223

Anti-Spectrin beta 5 antibody

  • 0
  • 0
style
left-column

Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
style
left-column
style
left-column

특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein G
Purification 관련 사항
Purity >95%
보관 버퍼
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
style
left-column

추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

The protein known as Metalloprotease Three and ATP/GTP Binding Protein-Like 2 or AGBL2 is part of the cytoplasmic carboxypeptidase family. This enzyme functions by removing glutamate residues from tubulin modifying microtubule properties and dynamics. AGBL2 has a molecular mass of around 83 kilodaltons. Researchers have identified its expression in several tissues including the brain liver and heart suggesting a broad role in the human body.
Biological function summary

AGBL2 participates in the regulation of neuronal microtubule stability. It forms a part of the cytosolic complex that influences cellular functions including maintaining the integrity of the cytoskeleton. AGBL2's activity is essential for the post-translational modification of tubulin which affects cell cycle progression and neuronal signaling. By modulating microtubule behavior AGBL2 contributes importantly to processes like intracellular transport and cell differentiation.

Pathways

AGBL2 actively engages in the regulation of the cytoskeleton. It is involved in the tubulin detyrosination/tyrosination cycle and interacts with other proteins like tubulin and MAP (microtubule-associated proteins) to stabilize or destabilize microtubules as needed. AGBL2 also plays roles in influencing the Wnt signaling pathway critical for developmental processes and cellular communication. By doing so it links with other regulatory proteins to modulate cellular responses.

Researchers have connected AGBL2 to neurodegenerative diseases and cancer. Abnormal expression or activity of AGBL2 can lead to disrupted microtubule dynamics causing neurological conditions such as Alzheimer's disease. AGBL2 interacts with proteins like tau whose hyperphosphorylation is a hallmark of Alzheimer's. Moreover in some cancers altered AGBL2 activity may affect cell proliferation by impacting microtubule stability indicating potential therapeutic targets for intervention.
style
left-column
style
left-column

제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

타겟 정보

Metallocarboxypeptidase that mediates deglutamylation of tubulin and non-tubulin target proteins. Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of tubulin protein. Specifically cleaves tubulin long-side-chains, while it is not able to remove the branching point glutamate. Also catalyzes the removal of polyglutamate residues from the carboxy-terminus of non-tubulin proteins such as MYLK.
See full target information AGBL2
style
left-column

제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Cell death & disease 16:405 PubMed40393967

2025

Cellular crosstalk mediated by Meteorin-like regulating hepatic stellate cell activation during hepatic fibrosis.

Applications

Unspecified application

Species

Unspecified reactive species

Yuxia Zhou,Guifang Wang,Lingling Liu,Lingyu Song,Laying Hu,Lu Liu,Lifen Xu,Tuanlao Wang,Lirong Liu,Yuanyuan Wang,Tian Zhang,Bing Guo
제품이 사용된 논문 모두 보기
style
left-column
style
left-column
style
right-column

Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com