AB156880

Anti-AK3L1 antibody [EPR7679]

Name: Anti-AK3L1 antibody [EPR7679]
Brand: Abcam Limited
SKU: AB156880
Rating: 1 (1 reviews)

RabMAb
Recombinant
각 태그의 뜻

(1 리뷰)

(1 출판물)

Rabbit Recombinant Monoclonal AK3L1 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication.

2 이미지

Immunocytochemistry/ Immunofluorescence - Anti-AK3L1 antibody [EPR7679] (AB156880)

ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-AK3L1 antibody [EPR7679] (AB156880)

Immunofluorescence of AK3L1 in A431 cells using ab156880 antibody at a dilution of 1/50.

Unknown

Western blot - Anti-AK3L1 antibody [EPR7679] (AB156880)

All lanes:

Western blot - Anti-AK3L1 antibody [EPR7679] (ab156880) at 1/1000 dilution

Lane 1:

Human fetal liver extract at 10 µg

Lane 2:

HepG2 cell lysate at 10 µg

Lane 3:

Raji cell lysate at 10 µg

Lane 4:

A431 cell lysate at 10 µg

Predicted band size: 25 kDa

true

주요 정보

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR7679

Isotype

IgG

Carrier free

Reacts with

Human

Applications

WB, ICC/IF

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/100", "ICCIF-species-notes": "" }, "Mouse": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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제품 세부 정보

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Protein A

보관 버퍼

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA

배송 시 보관 조건

Conditional Ambient

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

AK3L1 also known as adenylate kinase 3-like 1 is an enzyme with a molecular mass of approximately 26 kDa. This protein primarily catalyzes the reversible transfer of phosphate groups between ATP and AMP. AK3L1 is expressed mainly in the mitochondrial matrix playing a fundamental role in nucleotide metabolism. By facilitating energy transfer within the mitochondria AK3L1 ensures the availability of ATP and maintains cellular energy homeostasis.

Biological function summary

AK3L1 regulates mitochondrial energy metabolism and supports cellular functions. It operates as part of a network managing the mitochondrial adenylate kinase isoform family participating in mitochondrial phosphotransfer systems. AK3L1 contributes to sustaining energy balance especially in tissues with high-energy demand like muscle and brain. Within these systems AK3L1 interacts with other adenylate kinases and mitochondrial proteins to balance nucleotide ratios and prevent energy deficits.

Pathways

AK3L1 integrates into the wider cellular energy regulation and oxidative phosphorylation pathways. It supports the cellular energy landscape by linking to the citric acid cycle and oxidative phosphorylation essential for ATP production. AK3L1 coordinates with proteins like AK2 influencing energy metabolism and ensuring effective cellular processes. By aligning with these pathways AK3L1 plays a significant role in ensuring efficient bioenergetic processes.

AK3L1 features involvement in conditions such as mitochondrial myopathy and neurodegenerative disorders. Its dysfunction can disrupt mitochondrial energy balance linking it to diseases characterized by energy production deficits. The protein closely interacts with AK2 and other mitochondrial enzymes whose imbalance can further contribute to disease development. Understanding AK3L1's role provides insight into potential therapeutic targets for these disorders addressing the underlying mitochondrial dysfunctions.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Broad-specificity mitochondrial nucleoside phosphate kinase involved in cellular nucleotide homeostasis by catalyzing nucleoside-phosphate interconversions (PubMed : 19073142, PubMed : 19766732, PubMed : 23416111, PubMed : 24767988). Similar to other adenylate kinases, preferentially catalyzes the phosphorylation of the nucleoside monophosphate AMP with ATP as phosphate donor to produce ADP (PubMed : 19766732). Phosphorylates only AMP when using GTP as phosphate donor (PubMed : 19766732). In vitro, can also catalyze the phosphorylation of CMP, dAMP and dCMP and use GTP as an alternate phosphate donor (PubMed : 19766732, PubMed : 23416111). Moreover, exhibits a diphosphate kinase activity, producing ATP, CTP, GTP, UTP, TTP, dATP, dCTP and dGTP from the corresponding diphosphate substrates with either ATP or GTP as phosphate donors (PubMed : 23416111). Plays a role in controlling cellular ATP levels by regulating phosphorylation and activation of the energy sensor protein kinase AMPK (PubMed : 24767988, PubMed : 26980435). Plays a protective role in the cellular response to oxidative stress (PubMed : 19130895, PubMed : 23474458, PubMed : 26980435).

See full target information AK4

대체 명칭 보기

AK3, AK3L1, AK4, Adenylate kinase 3-like, GTP:AMP phosphotransferase AK4

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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Nature communications 16:7827 PubMed40846845

2025

Targeting spermine metabolism to overcome immunotherapy resistance in pancreatic cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Hanshen Yang,Xiaozhen Zhang,Sirui Zhang,Yanqing Yang,Yan Chen,Yangwei Jiang,Qingsong Lu,Lingyue Liu,Mengyi Lao,Weiran Du,Kang Sun,Lihong He,Jiatao Shi,Xinyuan Liu,Jinyuan Song,Na Lu,Junming Huang,Jinyan Huang,Ruhong Zhou,Xiongbin Lu,Tingbo Liang,Xueli Bai

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-AK3L1 antibody [EPR7679]

Immunocytochemistry/ Immunofluorescence - Anti-AK3L1 antibody [EPR7679] (AB156880)

Western blot - Anti-AK3L1 antibody [EPR7679] (AB156880)

관련 conjugated 항체와 다양한 조성의 항체 (1)

주요 정보

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

대체품

Primary Antibodies

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

제품 세부 정보

특성 및 보관 정보

제형

Purification 테크닉

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 조건

적절한 장기 보관 조건

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

대체 명칭 보기

제품이 사용된 논문 (1)

Product promise