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AB311840

Alexa Fluor® 594 Anti-Glucagon antibody [EP3070]

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Rabbit Recombinant Monoclonal GLP-1 antibody - conjugated to Alexa Fluor® 594. Suitable for Target Binding Affinity, Antibody Labelling, IHC-P and reacts with Human, Mouse, Rat samples.

관련 conjugated 항체와 다양한 조성의 항체 (7)

주요 정보

Host species

Rabbit

Clonality

Monoclonal

Clone number

EP3070

Isotype

IgG

Conjugation

Alexa Fluor® 594

Excitation/Emission

Ex: 590nm, Em: 617nm

Carrier free

No

Reacts with

Human, Mouse, Rat

Applications

Antibody Labelling, Target Binding Affinity, IHC-P

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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보완 제품

Primary Antibodies

AB307340

Alexa Fluor® 488 Anti-Glucagon antibody [EP3070]

BOND RX™ Validated|RabMAb|Recombinant|Trial Size|Trial Size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Alexa Fluor® 488 Anti-Glucagon antibody [EP3070] (AB307340)

  • 0
  • 0
Primary Antibodies

AB320260

Alexa Fluor® 555 Anti-Ghrelin antibody [EPR20502]

RabMAb|Recombinant

  • 0
  • 0
Primary Antibodies

AB225183

Alexa Fluor® 647 Anti-Somatostatin Receptor 2 antibody [UMB1]

BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Alexa Fluor® 647 Anti-Somatostatin Receptor 2 antibody [UMB1] (AB225183)

  • 0
  • 0
Primary Antibodies

AB196379

Alexa Fluor® 488 Anti-Synaptophysin antibody [YE269] - Synaptic Marker

RabMAb|Recombinant

Flow Cytometry - Alexa Fluor® 488 Anti-Synaptophysin antibody [YE269] - Synaptic Marker (AB196379)

  • 4
  • 4
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "TargetBindingAffinity" : {"fullname" : "Target Binding Affinity", "shortname":"Target Binding Affinity"}, "AntibodyLabelling" : {"fullname" : "Antibody Labelling", "shortname":"Antibody Labelling"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "TargetBindingAffinity-species-checked": "guaranteed", "TargetBindingAffinity-species-dilution-info": "", "TargetBindingAffinity-species-notes": "", "AntibodyLabelling-species-checked": "guaranteed", "AntibodyLabelling-species-dilution-info": "", "AntibodyLabelling-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" }, "Mouse": { "TargetBindingAffinity-species-checked": "guaranteed", "TargetBindingAffinity-species-dilution-info": "", "TargetBindingAffinity-species-notes": "", "AntibodyLabelling-species-checked": "guaranteed", "AntibodyLabelling-species-dilution-info": "", "AntibodyLabelling-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" }, "Rat": { "TargetBindingAffinity-species-checked": "guaranteed", "TargetBindingAffinity-species-dilution-info": "", "TargetBindingAffinity-species-notes": "", "AntibodyLabelling-species-checked": "guaranteed", "AntibodyLabelling-species-dilution-info": "", "AntibodyLabelling-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" } } }
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제품 세부 정보

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

How are conjugated primary antibodies validated?
This conjugated primary antibody is released using a quantitative quality control method that evaluates binding affinity post-conjugation and efficiency of antibody labeling.
For suitable applications and species reactivity, please refer to the unconjugated version of this clone.

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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein A
보관 버퍼
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle|Store in the dark
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

The glucagon receptor also known as GCGR is a protein located on cell membranes and is about 62 kDa in mass. This receptor belongs to the G protein-coupled receptor (GPCR) family which plays a role in transmitting signals from glucagon—a hormone involved in glucose metabolism. GCGR is expressed mainly in liver kidney and pancreatic cells as well as some regions of the brain. Scientists often use recombinant glucagon proteins to study receptor behaviors and interactions due to their specific binding properties.
Biological function summary

Glucagon receptor activation primarily mediates glucose homeostasis by stimulating hepatic glucose production. It facilitates glycogenolysis and gluconeogenesis processes that increase blood glucose levels especially when glucose availability is low. The receptor does not operate in a complex but interacts closely with secondary messengers like cAMP (cyclic adenosine monophosphate) to trigger downstream signaling cascades. This action allows cells to respond quickly to changing hormonal signals in the bloodstream.

Pathways

Glucagon receptor is an important component of the glucagon signaling pathway and plays a part in the insulin resistance pathway. Upon activation by glucagon the receptor stimulates adenylate cyclase increasing cAMP production which activates protein kinase A (PKA). This process is closely linked with the insulin receptor pathway where both influence glucose and lipid metabolism balancing the metabolic responses within the liver and other tissues.

Glucagon receptor involvement is significant in diabetes and metabolic syndrome. Dysfunctional GCGR activity can contribute to hyperglycemia in type 2 diabetes by failing to regulate glucose production properly. Additionally it links to lipid metabolism disorders affecting triglyceride levels. Researchers focus on the receptor's relationship with insulin and other hormones to develop therapeutic strategies targeting glucagon and its receptor to manage these conditions effectively. Anti-glucagon drugs are under investigation to better control glucose levels in diabetic patients.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

See full target information Glucagon

대체 명칭 보기

GCG, GGR, GLR_HUMAN, Gcgr, Glucagon receptor, Glucagon receptor precursor, MGC138246
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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