Alexa Fluor® 647 Anti-Gpnmb antibody [EPR18226-147]
- RabMAb
- Recombinant
- 각 태그의 뜻
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Rabbit Recombinant Monoclonal GPNMB antibody - conjugated to Alexa Fluor® 647. Suitable for ICC/IF and reacts with Mouse samples.
대체 명칭 보기
Dchil, Hgfin, Nmb, Gpnmb, Transmembrane glycoprotein NMB, DC-HIL, Dendritic cell-associated transmembrane protein, Osteoactivin
- ICC/IF
Supplier Data
Immunocytochemistry/ Immunofluorescence - Alexa Fluor® 647 Anti-Gpnmb antibody [EPR18226-147] (AB300475)
Immunofluorescent analysis of 100% methanol-fixed, 0.1% TritonX-100 permeabilized L-929 (mouse connective tissue fibroblast) cells labelling GPNMB with ab300475 at 1/50 (10.0 ug/ml) msd2577,(Green). Confocal image showing cytoplasmic staining in L-929 cellsNegative control : EL4 (PMID : 19320736) is observed. ab195887 Anti-alpha Tubulin mouse monoclonal antibody - Microtubule Marker (Alexa Fluor® 488) was used to counterstain tubulin at 1/200 2.5ug/ml msd2577 (Red). The Nuclear counterstain was DAPI (Blue).
관련 conjugated 항체와 다양한 조성의 항체 (3)
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Anti-GPNMB antibody [EPR18226-147]
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Anti-GPNMB antibody [EPR18226-147] - BSA and Azide free
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519 Alexa Fluor® 488
Alexa Fluor® 488 Anti-GPNMB antibody [EPR18226-147]
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Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free batch production
For more information, read more on recombinant antibodies.
Alexa Fluor® is a registered trademark of Molecular Probes, Inc, a Thermo Fisher Scientific Company. The Alexa Fluor® dye included in this product is provided under an intellectual property license from Life Technologies Corporation. As this product contains the Alexa Fluor® dye, the purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). As this product contains the Alexa Fluor® dye the sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: in manufacturing; (ii) to provide a service, information, or data in return for payment (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are sold for use in research. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.
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This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
GPNMB plays versatile roles in promoting cell growth differentiation and repair. It is involved in processes like tissue regeneration possibly due to its role in cell adhesion and migration. The protein also partakes in osteoclast differentiation and bone resorption therefore linking to skeletal homeostasis. GPNMB forms part of a broader protein complex at the cellular junctions interacting with integrins to mediate its functions.
Pathways
GPNMB features prominently in osteoclastogenesis and melanoma metastasis pathways. It cooperates with RANKL an important protein in bone metabolism by influencing osteoclast differentiation and activation. In the context of melanoma GPNMB's action in pathways may enhance tumor proliferation and invasion possibly interacting with signaling molecules like AKT or ERK although the specifics remain actively researched.
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Product promise
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com