AB5598

Anti-Alpha B Crystallin (phospho S45) antibody

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(4 제품이 사용된 논문 )

Rabbit Polyclonal Alpha B Crystallin phospho S45 antibody. Suitable for WB and reacts with Recombinant fragment - Cow samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human CRYAB phospho S45 aa 1-100.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Applications

applications

Immunogen

Synthetic Peptide within Human CRYAB phospho S45 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.

P02511

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Reactivity 정보

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Immunogen

보관 버퍼

Preservative: 0.05% Sodium azide Constituents: PBS, 3% BSA

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Alpha B Crystallin also known as CRYAB or alpha B crystallin protein is a small heat shock protein with a molecular mass of approximately 20 kDa. It is expressed in various tissues including the eye lens heart skeletal muscles and the brain. Alpha B Crystallin functions mechanically as a chaperone helping to prevent the aggregation of unfolded proteins by stabilizing them. This protein plays an important role in maintaining proper cellular function especially under stress conditions.

Biological function summary

Alpha B crystallin performs as part of the larger small heat shock protein family which contributes to the cellular defense system. It acts primarily as a chaperone binding to denatured proteins to protect the cells from damage during environmental stresses such as heat and oxidative stress. Alpha B crystallin often forms oligomeric complexes which increases its protective properties. This protein exhibits significant anti-apoptotic functions by interacting with various apoptosis-regulating factors contributing to cellular survival.

Pathways

Alpha B crystallin integrates into the cellular stress response and apoptosis pathways. It involves the PI3K/Akt signaling pathway known for regulating cell survival and preventing programmed cell death. Alpha B crystallin also interacts with other proteins such as Bcl-2 further enhancing its role in anti-apoptotic activities. Its contribution to these pathways highlights its protective function during cellular stress situations.

Alpha B crystallin is associated with cataracts and dilated cardiomyopathy. It plays a significant role in maintaining lens transparency and mutations or dysfunctions in alpha B crystallin can lead to cataract development. Similarly in cardiac tissue abnormal alpha B crystallin expression links to dilated cardiomyopathy. The protein is also known to associate with other structural proteins like desmin where disruptions may contribute to muscle-related diseases.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. In lens epithelial cells, stabilizes the ATP6V1A protein, preventing its degradation by the proteasome (By similarity).

See full target information CRYAB phospho S45

대체 명칭 보기

CRYA2, HSPB5, CRYAB, Alpha-crystallin B chain, Alpha(B)-crystallin, Heat shock protein beta-5, Heat shock protein family B member 5, Renal carcinoma antigen NY-REN-27, Rosenthal fiber component, HspB5

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제품이 사용된 논문 (4)

Recent publications for all applications. Explore the 전체 목록 and refine your search

The Journal of clinical investigation 135: PubMed39932799

2025

Phosphorylation of CRYAB induces a condensatopathy to worsen post-myocardial infarction left ventricular remodeling.

Applications

Unspecified application

Species

Unspecified reactive species

Moydul Islam,David R Rawnsley,Xiucui Ma,Walter Navid,Chen Zhao,Xumin Guan,Layla Foroughi,John T Murphy,Honora Navid,Carla J Weinheimer,Attila Kovacs,Jessica Nigro,Aaradhya Diwan,Ryan P Chang,Minu Kumari,Martin E Young,Babak Razani,Kenneth B Margulies,Mahmoud Abdellatif,Simon Sedej,Ali Javaheri,Douglas F Covey,Kartik Mani,Abhinav Diwan

Antioxidants (Basel, Switzerland) 10: PubMed34208998

2021

MEK1/2-ERK Pathway Alterations as a Therapeutic Target in Sporadic Alzheimer's Disease: A Study in Senescence-Accelerated OXYS Rats.

Applications

Unspecified application

Species

Unspecified reactive species

Natalia A Muraleva,Nataliya G Kolosova,Natalia A Stefanova

Proceedings of the National Academy of Sciences of 114:E1745-E1754 PubMed28196893

2017

Phosphorylation of αB-crystallin supports reactive astrogliosis in demyelination.

Applications

Unspecified application

Species

Unspecified reactive species

Hedwich F Kuipers,Jane Yoon,Jack van Horssen,May H Han,Paul L Bollyky,Theo D Palmer,Lawrence Steinman

Japanese journal of ophthalmology 53:436-9 PubMed19763765

2009

Diagnostic Western blot for lens-specific proteins in aqueous fluid after traumatic lens-induced uveitis.

Applications

Unspecified application

Species

Unspecified reactive species

Masaki Tanito,Sachiko Kaidzu,Tohru Katsube,Shin Nonoyama,Yasuyuki Takai,Akihiro Ohira

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Alpha B Crystallin (phospho S45) antibody

주요 정보

Host species

Clonality

Isotype

Carrier free

Applications

Immunogen

대체품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 기간

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

대체 명칭 보기

제품이 사용된 논문 (4)

Product promise