JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB134706

Anti-alpha Defensin 1 antibody

Be the first to review this product! 리뷰 제출

|

(1 출판물)

Rabbit Polyclonal alpha Defensin 1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human DEFA1.

대체 명칭 보기

DEF1, DEFA2, MRS, DEFA1B, DEFA1, Neutrophil defensin 1, HNP-1, HP-1, HP1

1 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-alpha Defensin 1 antibody (AB134706)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-alpha Defensin 1 antibody (AB134706)

Immunohistochemical labelling of paraffin embedded human breast carcinoma tissue with ab134706 at 1/50 dilution

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human DEFA1. The exact immunogen used to generate this antibody is proprietary information.

P59665

Specificity

ab134706 detects endogenous levels of alpha 1 Defensin.

style
left-column

보완 제품

Primary Antibodies

AB245833

Anti-BAFF antibody [EPR22238] - BSA and Azide free

RabMAb|Recombinant

Flow Cytometry - Anti-BAFF antibody [EPR22238] - BSA and Azide free (AB245833)

  • 0
  • 0
Primary Antibodies

AB200836

Anti-PHAPI2 / APRIL antibody [EPR14588]

20ul selling size|RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PHAPI2 / APRIL antibody [EPR14588] (AB200836)

  • 0
  • 0
Primary Antibodies

AB180515

Anti-alpha Defensin 5 antibody [EPR14309(B)]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-alpha Defensin 5 antibody [EPR14309(B)] (AB180515)

  • 0
  • 1
Primary Antibodies

AB124964

Anti-alpha smooth muscle Actin antibody [EPR5368]

BOND RX™ Validated|RabMAb|Recombinant|KO Validated|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-alpha smooth muscle Actin antibody [EPR5368] (AB124964)

  • 5
  • 19
style
left-column

Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/100", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }
style
left-column
style
left-column

특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
style
left-column

추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Alpha defensin 1 also known as human defensin 1 or neutrophil defensin 1 is a small cationic peptide with a mass of approximately 3-4 kDa. This protein is mainly expressed in neutrophils where it plays an essential role in the body's innate immune system. Additional sites of expression include Paneth cells in the intestines where alpha defensins contribute to mucosal immunity. Its structure consists of three intramolecular disulfide bonds that confer stability and enable its antimicrobial properties.
Biological function summary

The alpha defensin 1 peptide disrupts the integrity of microbial membranes by inserting into microbial lipid bilayers leading to membrane permeabilization and lysis. This activity is not limited to bacteria; it also affects fungi and some viruses. The peptide is not part of a complex but it acts as a standalone antimicrobial agent. Besides its antimicrobial role alpha defensin 1 can modulate inflammatory responses and influence wound healing. It interacts with chemokines and cytokines affecting immune modulation.

Pathways

Alpha defensin 1 is integral to the antimicrobial response pathway and innate immunity processes. In the antimicrobial defense pathway it collaborates with other defensins and lysozymes to ensure pathogen elimination. In the innate immunity processes it works in conjunction with cytokines such as IL-8 which recruits more neutrophils to infection sites. Both pathways highlight alpha defensin 1's importance in both direct defense mechanisms and immune signaling.

Alpha defensin 1 is linked to inflammatory conditions and autoimmune diseases such as Crohn’s disease and ulcerative colitis. In Crohn's disease altered levels of alpha defensin 1 relate to intestinal inflammation and microbial imbalance. It is also connected to rheumatoid arthritis where its role in inflammation may exacerbate disease activity. In these conditions alpha defensin 1 interacts with other proteins including TNF-alpha an important cytokine involved in inflammatory pathways.
style
left-column
style
left-column

제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

타겟 정보

Effector molecule of the innate immune system that acts via antibiotic-like properties against a broad array of infectious agents including bacteria, fungi, and viruses or by promoting the activation and maturation of some APCs (PubMed : 15616305, PubMed : 17142766, PubMed : 20220136, PubMed : 24236072). Interacts with the essential precursor of cell wall synthesis lipid II to inhibit bacterial cell wall synthesis (PubMed : 20214904). Inhibits adenovirus infection via inhibition of viral disassembly at the vertex region, thereby restricting the release of internal capsid protein pVI, which is required for endosomal membrane penetration during cell entry (PubMed : 18191790). In addition, interaction with adenovirus capsid leads to the redirection of viral particles to TLR4 thereby promoting a NLRP3-mediated inflammasome response and interleukin 1-beta (IL-1beta) release (PubMed : 35080426). Induces the production of proinflammatory cytokines including type I interferon (IFN) in plasmacytoid dendritic cells (pDCs) by triggering the degradation of NFKBIA and nuclear translocation of IRF1, both of which are required for activation of pDCs (PubMed : 27031443).
See full target information DEFA1
style
left-column

제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20:2380-2391 PubMed32167668

2020

Signaling through tumor necrosis receptor 2 induces stem cell marker in CD133 regenerating tubular epithelial cells in acute cell-mediated rejection of human renal allografts.

Applications

Unspecified application

Species

Unspecified reactive species

John R Bradley,Jun Wang,Victoria Bardsley,Verena Broecker,Sathia Thiru,Jordan S Pober,Rafia S Al-Lamki
제품이 사용된 논문 모두 보기
style
left-column
style
left-column
style
right-column

Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com