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AB133425

Anti-Angiopoietin 1 antibody

3

(1 리뷰)

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(14 제품이 사용된 논문 )

Goat Polyclonal Angiopoietin 1 antibody. Suitable for IHC-P, WB and reacts with Human, Rat, Recombinant full length protein - Human samples. Cited in 14 publications. Immunogen corresponding to Synthetic Peptide within Human ANGPT1 aa 50-100.

대체 명칭 보기

KIAA0003, ANGPT1, Angiopoietin-1, ANG-1

2 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Angiopoietin 1 antibody (AB133425)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Angiopoietin 1 antibody (AB133425)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human lung, respiratory epithelium tissue labelling Angiopoietin 1 with ab133425 antibody at 2.5μg/ml, followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Western blot - Anti-Angiopoietin 1 antibody (AB133425)
  • WB

Unknown

Western blot - Anti-Angiopoietin 1 antibody (AB133425)

Lane 1:

Western blot - Anti-Angiopoietin 1 antibody (ab133425) at 1 µg/mL

Lane 2:

Western blot - Anti-Angiopoietin 1 antibody (ab133425) at 1 mg/mL

Lane 3:

anti-DYKDDDDK Tag antibody at 1/1000 dilution

Lanes 1 and 3:

HEK293 lysate, overexpressing Human Angiopoietin 1 with DYKDDDDK tag at 10 µg

Lane 2:

HEK293 lysate, mock-transfected at 10 µg

Predicted band size: 57 kDa

true

주요 정보

Host species

Goat

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human, Rat

Applications

IHC-P, WB

applications

Immunogen

Synthetic Peptide within Human ANGPT1 aa 50-100. The exact immunogen used to generate this antibody is proprietary information.

Q15389

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대체품

Primary Antibodies

AB183701

Anti-Angiopoietin 1 antibody [EPR2888(N)]

RabMAb|Recombinant|20ul selling size

Western blot - Anti-Angiopoietin 1 antibody [EPR2888(N)] (AB183701)

  • 0
  • 0
Primary Antibodies

AB94684

Anti-Angiopoietin 1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Angiopoietin 1 antibody (AB94684)

  • 4
  • 2
Primary Antibodies

AB8451

Anti-Angiopoietin 1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Angiopoietin 1 antibody (AB8451)

  • 4
  • 3
Primary Antibodies

AB183702

Anti-Angiopoietin 1 antibody [EPR2889(N)]

RabMAb|Recombinant

Western blot - Anti-Angiopoietin 1 antibody [EPR2889(N)] (AB183702)

  • 0
  • 0

보완 제품

Primary Antibodies

AB155106

Anti-Angiopoietin 2/ANG2 antibody [EPR2891(2)]

RabMAb|Recombinant|20ul selling size

Western blot - Anti-Angiopoietin 2/ANG2 antibody [EPR2891(2)] (AB155106)

  • 4
  • 2
Primary Antibodies

AB221154

Anti-TIE2 antibody [EPR21915]

RabMAb|Recombinant|20ul selling size

Flow Cytometry - Anti-TIE2 antibody [EPR21915] (AB221154)

  • 0
  • 0
Primary Antibodies

AB9546

Anti-VEGFC antibody

ELISA - Anti-VEGFC antibody (AB9546)

  • 0
  • 0
Primary Antibodies

AB283655

Anti-iNOS antibody [RM1017]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-iNOS antibody [RM1017] (AB283655)

  • 0
  • 1
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "2.5 µg/mL", "IHCP-species-notes": "<p></p>", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "2.5 µg/mL", "IHCP-species-notes": "<p></p>", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "<p></p>" }, "Dog": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Pig": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Recombinant full length protein - Human": { "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "<p></p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: 99% Tris buffered saline, 0.5% BSA
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Angiopoietin 1 also known as Ang1 or Angpt1 is a protein important to the vascular system with a molecular mass of around 70 kDa. It is expressed widely in endothelial cells and fibroblasts. Angiopoietin 1 functions mechanically to bind the Tie2 receptor triggering signaling pathways that regulate blood vessel maturation and stability. This interaction is important for the development and maintenance of the blood vessel network.
Biological function summary

Angiopoietin 1 supports the structural integrity of blood vessels by interacting with the Tie2 receptor as part of a signaling complex. It helps prevent vascular leak and promotes endothelial cell survival migration and adhesion. By playing such roles Angiopoietin 1 is fundamental for maintaining vascular homeostasis and facilitating proper blood flow throughout the body. It also influences the immune response by modulating endothelial functions.

Pathways

Angiopoietin 1's involvement is most notable within the PI3K/AKT pathway and the MAPK pathway which are important for signaling cell survival and growth. These pathways work closely with other proteins such as VEGF (Vascular Endothelial Growth Factor) in angiogenesis and vascular remodeling. Angiopoietin 1 interacts with its related pathways to ensure that blood vessels remain functional and adaptive to physiological changes.

Angiopoietin 1 plays significant roles in cardiovascular diseases like atherosclerosis and diabetic vascular complications. Its dysregulation can lead to abnormalities in vascular maintenance and repair. There is also an association between Angiopoietin 1 and proteins like VEGF in cancer as both have roles in tumor angiogenesis. Understanding Angiopoietin 1's function could provide insights into therapeutic strategies for these conditions.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Binds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. Plays an important role in the regulation of angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Required for normal angiogenesis and heart development during embryogenesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. Mediates blood vessel maturation/stability. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme.
See full target information ANGPT1
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제품이 사용된 논문 (14)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Biomolecules and biomedicine 23:161-169 PubMed35674770

2023

Prognostic and predictive significance of VEGF, CD31, and Ang-1 in patients with metastatic clear cell renal cell carcinoma treated with first-line sunitinib.

Applications

Unspecified application

Species

Unspecified reactive species

Marija Kraljević,Inga Marijanović,Maja Barbarić,Emir Sokolović,Merima Bukva,Timur Cerić,Teo Buhovac

Computational and mathematical methods in medicine 2022:9397478 PubMed35495890

2022

The Effect of Qingre Huayu Recipe on Wound Healing after Anal Fistulotomy in Sprague-Dawley Rats.

Applications

Unspecified application

Species

Unspecified reactive species

Jiazhi Gao,Jiandong Wang,Ping Chen,Peilin Ding,Liang Tian,Biao Liang,Zhan Shi

Aging 13:24675-24685 PubMed34815366

2021

BMAL1 may be involved in angiogenesis and peritumoral cerebral edema of human glioma by regulating VEGF and ANG2.

Applications

Unspecified application

Species

Unspecified reactive species

Fan Wang,CaiYan Li,Fei Han,LvAn Chen,Ling Zhu

Biochimica et biophysica acta. Molecular basis of disease 1868:166295 PubMed34718118

2021

SARS-CoV-2 infection negatively affects ovarian function in ART patients.

Applications

Unspecified application

Species

Unspecified reactive species

Yamila Herrero,Natalia Pascuali,Candela Velázquez,Gonzalo Oubiña,Vanesa Hauk,Ignacio de Zúñiga,Mariana Gómez Peña,Gustavo Martínez,Mariano Lavolpe,Florencia Veiga,Fernando Neuspiller,Dalhia Abramovich,Leopoldina Scotti,Fernanda Parborell

International journal of molecular sciences 22: PubMed34681670

2021

Bazedoxifene, a Selective Estrogen Receptor Modulator, Promotes Functional Recovery in a Spinal Cord Injury Rat Model.

Applications

Unspecified application

Species

Unspecified reactive species

Yiyoung Kim,Eun Ji Roh,Hari Prasad Joshi,Hae Eun Shin,Hyemin Choi,Su Yeon Kwon,Seil Sohn,Inbo Han

The Journal of neuroscience : the official journal 40:1943-1955 PubMed31974206

2020

Elevated TRPV4 Levels Contribute to Endothelial Damage and Scarring in Experimental Spinal Cord Injury.

Applications

Unspecified application

Species

Unspecified reactive species

Hemant Kumar,Chang Su Lim,Hyemin Choi,Hari Prasad Joshi,Kyoung-Tae Kim,Yong Ho Kim,Chul-Kyu Park,Hwan Myung Kim,In-Bo Han

Molecular and cellular endocrinology 499:110591 PubMed31546019

2019

Metformin has a direct effect on ovarian cells that is dependent on organic cation transporters.

Applications

Unspecified application

Species

Unspecified reactive species

Mariana Di Pietro,Candela Velazquez,María Eugenia Matzkin,Mónica Beatriz Frungieri,Mariana Gómez Peña,Ignacio de Zúñiga,Natalia Pascuali,Griselda Irusta,María Silvia Bianchi,Fernanda Parborell,Dalhia Abramovich

International journal of cancer 145:2157-2169 PubMed30924128

2019

Fibulin-7 is overexpressed in glioblastomas and modulates glioblastoma neovascularization through interaction with angiopoietin-1.

Applications

Unspecified application

Species

Unspecified reactive species

Susana de Vega,Akihide Kondo,Mario Suzuki,Hajime Arai,Shabierjiang Jiapaer,Hemragul Sabit,Mitsutoshi Nakada,Tomoko Ikeuchi,Muneaki Ishijima,Eri Arikawa-Hirasawa,Yoshihiko Yamada,Yasunori Okada

BioMed research international 2017:9390565 PubMed29259991

2017

Enhancement of Angiogenesis by Ultrasound-Targeted Microbubble Destruction Combined with Nuclear Localization Signaling Peptides in Canine Myocardial Infarction.

Applications

Unspecified application

Species

Unspecified reactive species

Jingjing Cui,Qing Deng,Qing Zhou,Sheng Cao,Nan Jiang,Yijia Wang,Jinling Chen,Bo Hu,Tuantuan Tan

Molecular medicine reports 16:565-572 PubMed28586046

2017

Enhanced effect of nuclear localization signal peptide during ultrasound‑targeted microbubble destruction‑mediated gene transfection.

Applications

WB

Species

Human

Sheng Cao,Qing Zhou,Jin-Ling Chen,Nan Jiang,Yi-Jia Wang,Qing Deng,Bo Hu,Rui-Qiang Guo
제품이 사용된 논문 모두 보기
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Product promise

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