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AB199106

Anti-Angiopoietin 4 antibody

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Rabbit Polyclonal Angiopoietin 4 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human ANGPT4.

대체 명칭 보기

ANG3, ANG4, ANGPT4, Angiopoietin-4, ANG-4, Angiopoietin-3, ANG-3

2 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Angiopoietin 4 antibody (AB199106)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Angiopoietin 4 antibody (AB199106)

Immunohistochemical analysis of paraffin-embedded Human colon cancer tissue labeling Angiopoietin 4 with ab199106 at 1/70 dilution.

Western blot - Anti-Angiopoietin 4 antibody (AB199106)
  • WB

Supplier Data

Western blot - Anti-Angiopoietin 4 antibody (AB199106)

Gel : 8% SDS-PAGE.

All lanes:

Western blot - Anti-Angiopoietin 4 antibody (ab199106) at 1/480 dilution

Lane 1:

Human right lung cancer tissue lysate at 40 µg

Lane 2:

Human left lung cancer tissue lysate at 40 µg

Predicted band size: 57 kDa

false

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Synthetic Peptide within Human ANGPT4. The exact immunogen used to generate this antibody is proprietary information.

Q9Y264

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대체품

Primary Antibodies

AB87877

Anti-Angiopoietin 4 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Angiopoietin 4 antibody (AB87877)

  • 0
  • 0

보완 제품

Assay Kits

AB193693

Human ANGPT4 ELISA Kit

Sandwich ELISA - Human ANGPT4 ELISA Kit (AB193693)

  • 0
  • 0
Primary Antibodies

AB232785

Anti-ICAM5 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ICAM5 antibody (AB232785)

  • 0
  • 0
Primary Antibodies

AB185236

Anti-PRSS8 antibody [EPR15327]

RabMAb|Recombinant

Immunoprecipitation - Anti-PRSS8 antibody [EPR15327] (AB185236)

  • 0
  • 0
Primary Antibodies

AB201968

Anti-Desmoglein 3/PVA antibody [6G2C11]

Flow Cytometry - Anti-Desmoglein 3/PVA antibody [6G2C11] (AB201968)

  • 0
  • 0
Primary Antibodies

AB255610

Anti-Stanniocalcin 2/STC-2 antibody [EPR22866-10]

20ul selling size|BOND RX™ Validated|RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-Stanniocalcin 2/STC-2 antibody [EPR22866-10] (AB255610)

  • 5
  • 2
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/200 - 1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/300", "IHCP-species-notes": "<p></p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Angiopoietin 4 also known as ANGPT4 or AGP4 is a secreted glycoprotein involved in vascular development. This protein has a molecular mass of around 56 kDa. ANGPT4 is expressed in a variety of tissues including the lung heart and kidney. It functions by interacting with the Tie receptors influencing vascular remodeling and angiogenesis. Angiopoietin 4 shares homology with other angiopoietins but has distinct regulatory roles compared to its counterparts.
Biological function summary

Angiopoietin 4 regulates angiogenesis and vascular permeability. It acts independently and does not part of a known protein complex. ANGPT4 contributes to the restructuring of blood vessels by promoting endothelial cell survival and migration. By balancing the actions of other angiopoietins such as Angiopoietin 1 it supports the maturation and stabilization of vascular networks impacting overall vascular function and growth.

Pathways

Angiopoietin 4 affects early morphogenetic signaling in vascular development. ANGPT4 operates within the angiopoietin-Tie signaling pathway important for angiogenesis and lymphangiogenesis. It interacts with Tie2 a receptor tyrosine kinase to mediate these effects. Within the pathway ANGPT4 coordinates with Angiopoietin 1 and Angiopoietin 2 modulating the balance between vessel stability and growth as required.

Angiopoietin 4 shows relevance to conditions like cancer and diabetic retinopathy. Abnormal expression or signaling of ANGPT4 can lead to defective vascular structures contributing to the pathology of these diseases. In cancer altered ANGPT4 and its interaction with Tie2 may disrupt normal angiogenesis facilitating tumor growth. Additionally in diabetic retinopathy ANGPT4 expression changes can exacerbate abnormal vessel formation highlighting its importance alongside Angiopoietin 2 in disease progression.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes endothelial cell survival, migration and angiogenesis.
See full target information ANGPT4
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Aging 12:6240-6259 PubMed32276266

2020

Inhibition of esophageal-carcinoma cell proliferation by genistein via suppression of JAK1/2-STAT3 and AKT/MDM2/p53 signaling pathways.

Applications

Unspecified application

Species

Unspecified reactive species

Jing Gao,Rongmu Xia,Jianbo Chen,Jing Gao,Xianyang Luo,Chunlin Ke,Caihong Ren,Jiayi Li,Yanjun Mi
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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