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AB196942

Anti-Annexin-6/ANXA6 antibody

5

(4 리뷰들)

|

(1 출판물)

Rabbit Polyclonal Annexin-6/ANXA6 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human, Mouse samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ANXA6.

대체 명칭 보기

ANX6, ANXA6, Annexin A6, 67 kDa calelectrin, Annexin VI, Annexin-6, Calphobindin-II, Chromobindin-20, Lipocortin VI, Protein III, p68, p70, CPB-II

5 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Annexin-6/ANXA6 antibody (AB196942)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Annexin-6/ANXA6 antibody (AB196942)

Immunohistochemical analysis of paraffin-embedded Human lung tissue labeling Annexin-6/ANXA6 with ab196942 at 1/200 dilution.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Annexin-6/ANXA6 antibody (AB196942)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Annexin-6/ANXA6 antibody (AB196942)

Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue labeling Annexin-6/ANXA6 with ab196942 at 1/200 dilution.

Immunocytochemistry/ Immunofluorescence - Anti-Annexin-6/ANXA6 antibody (AB196942)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-Annexin-6/ANXA6 antibody (AB196942)

Immunofluorescent analysis of A549 cells labeling Annexin-6/ANXA6 with ab196942 at 1/50 dilution.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Annexin-6/ANXA6 antibody (AB196942)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Annexin-6/ANXA6 antibody (AB196942)

Immunohistochemical analysis of paraffin-embedded Mouse liver tissue labeling Annexin-6/ANXA6 with ab196942 at 1/200 dilution.

Western blot - Anti-Annexin-6/ANXA6 antibody (AB196942)
  • WB

Supplier Data

Western blot - Anti-Annexin-6/ANXA6 antibody (AB196942)

All lanes:

Western blot - Anti-Annexin-6/ANXA6 antibody (ab196942) at 1/500 dilution

Lane 1:

K562 cell extract

Lane 2:

THP-1 cell extract

Lane 3:

MCF7 cell extract

Lane 4:

Mouse spleen extract

Lane 5:

Mouse heart extract

Lane 6:

Mouse liver extract

Lane 7:

Mouse skeletal muscle extract

Lane 8:

Mouse lung extract

Predicted band size: 76 kDa

false

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

IHC-P, WB, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human ANXA6. The exact immunogen used to generate this antibody is proprietary information.

P08133

Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle

추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Annexin-6 also known as ANXA6 is a member of the annexin family of proteins. It has a mass of approximately 68 kDa and is expressed in various tissues with substantial presence in muscle and liver. This protein acts mechanically by binding to membranes in a calcium-dependent manner playing a role in membrane-associated processes such as endocytosis and exocytosis. Annexin-6 can also interact with cytoskeletal elements influencing cell structure and stability.
Biological function summary

Annexin-6 functions as a versatile scaffold that organizes multiprotein complexes. It modulates membrane trafficking processes and participates in signaling pathways within the cell. This protein can influence intracellular calcium homeostasis by interacting with calcium channels and transporters making it an integral part of cellular signaling and communication.

Pathways

Annexin-6 plays a role in the MAPK and PI3K/Akt signaling pathways. It associates with proteins such as Ras and Protein Kinase C impacting cell proliferation survival and differentiation. These interactions highlight the importance of annexin-6 in cellular responses to external stimuli and help regulate various physiological processes in the body.

Annexin-6 has been linked to cardiac disorders and cancer. In the context of cardiac health it interacts with proteins like phospholamban and calmodulin to influence heart muscle function and calcium regulation. In cancer annexin-6's involvement in the Akt signaling pathway can affect tumor growth and metastasis often interacting with other proteins like EGFR and HER2. This makes it a significant protein of interest in disease research and potential therapeutic targeting.

제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

타겟 정보

May associate with CD21. May regulate the release of Ca(2+) from intracellular stores.
See full target information ANXA6

제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

FASEB journal : official publication of the Federa 29:3773-87 PubMed26023182

2015

Annexin A4 is a novel direct regulator of adenylyl cyclase type 5.

Applications

Unspecified application

Species

Unspecified reactive species

Alexander Heinick,Xenia Husser,Kirsten Himmler,Uwe Kirchhefer,Frank Nunes,Jan S Schulte,Matthias D Seidl,Christina Rolfes,John R Dedman,Marcia A Kaetzel,Volker Gerke,Wilhelm Schmitz,Frank U Müller
제품이 사용된 논문 모두 보기

Product promise

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