JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB113099

Anti-AP3S1 antibody

Be the first to review this product! 리뷰 제출

|

(1 출판물)

Rabbit Polyclonal AP3S1 antibody. Suitable for WB and reacts with Mouse samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human AP3S1.

대체 명칭 보기

CLAPS3, AP3S1, AP-3 complex subunit sigma-1, AP-3 complex subunit sigma-3A, Adaptor-related protein complex 3 subunit sigma-1, Sigma-3A-adaptin, Sigma-adaptin 3a, Sigma3A-adaptin

1 이미지
Western blot - Anti-AP3S1 antibody (AB113099)
  • WB

Unknown

Western blot - Anti-AP3S1 antibody (AB113099)

Lane 1:

Western blot - Anti-AP3S1 antibody (ab113099) at 1 µg/mL

Lane 2:

Western blot - Anti-AP3S1 antibody (ab113099) at 2 µg/mL

All lanes:

Mouse kidney tissue lysate at 15 µg

Predicted band size: 21 kDa

false

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse

Applications

WB

applications

Immunogen

Synthetic Peptide within Human AP3S1. The exact immunogen used to generate this antibody is proprietary information.

Q92572

Specificity

ab113099 will detect only the two larger AP3S1 isoforms. ab113099 is not predicted to cross-react with other AP3 protein family members.

style
left-column

보완 제품

Primary Antibodies

AB174280

Anti-TGN46 antibody [EPR12676] - Golgi Marker

20ul selling size|RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TGN46 antibody [EPR12676] - Golgi Marker (AB174280)

  • 0
  • 0
Primary Antibodies

AB218624

Anti-Rab5 antibody [EPR21801] - Early Endosome Marker

20ul selling size|KO Validated|RabMAb|Recombinant|Lab Essentials

Immunocytochemistry/ Immunofluorescence - Anti-Rab5 antibody [EPR21801] - Early Endosome Marker (AB218624)

  • 4
  • 3
Primary Antibodies

AB278043

Anti-LAMP1 antibody [EPR24395-31] - Lysosome Marker

BOND RX™ Validated|RabMAb|KO Validated|Recombinant|20ul selling size

Multiplex immunohistochemistry - Anti-LAMP1 antibody [EPR24395-31] - Lysosome Marker (AB278043)

  • 0
  • 0
Biochemicals

AB120503

BAPTA-AM, Ca2+ chelator

Immunocytochemistry/ Immunofluorescence - BAPTA-AM, Ca2+ chelator (AB120503)

  • 0
  • 0
style
left-column

Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "<p></p>" } } }
style
left-column
style
left-column

특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
Purification 관련 사항
ab113099 is purified by affinity chromatography via a peptide column.
보관 버퍼
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
Up to 12 months
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
style
left-column

추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

AP3S1 also known as adaptor-related protein complex 3 sigma-1 is a subunit of the AP-3 adaptor complex. This protein plays a role in the sorting and trafficking of membrane proteins to lysosomes and other intracellular compartments. AP3S1 is expressed in a variety of tissues with notable expression in brain and immune cells. It has a mass of approximately 19 kDa. The protein serves as a critical component for the proper targeting and vesicle budding processes within cells.
Biological function summary

AP3S1 interacts as a part of the multisubunit AP-3 complex. This complex consists of four subunits and participates in the transport of proteins from the trans-Golgi network to lysosomes. The presence of AP3S1 ensures the selective packaging of proteins into vesicles destined for lysosomal compartments. This function contributes to cellular homeostasis and effective degradation of lysosomal substrates. The AP-3 complex including AP3S1 is therefore integral to intracellular protein sorting.

Pathways

AP3S1's role in vesicular transport places it within the lysosome biogenesis and protein trafficking pathways. It interacts with proteins like clathrin which aids in coat formation around vesicles and facilitates the transport function of the AP-3 complex. This protein along with others in the AP-3 complex ensures the proper delivery of enzymes and other proteins necessary for lysosomal function. Its involvement in these pathways highlights its importance in maintaining cellular balance and nutrient processing.

Defects in AP3S1 are linked to Hermansky-Pudlak syndrome a rare genetic disorder characterized by albinism prolonged bleeding and lung fibrosis. The dysfunction of AP3S1 affects the function of other AP-3 subunits causing improper lysosomal trafficking. Another related protein dysbindin has been associated with schizophrenia suggesting the AP-3 complex might affect neurological pathways through protein sorting errors. Understanding AP3S1's role might offer insights into these conditions and potential therapeutic targets.
style
left-column
style
left-column

제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

타겟 정보

Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.
See full target information AP3S1
style
left-column

제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Developmental cell 60:2744-2760.e9 PubMed40460835

2025

ATG9A and ARFIP2 cooperate to control PI4P levels for lysosomal repair.

Applications

Unspecified application

Species

Unspecified reactive species

Stefano De Tito,Eugenia Almacellas,Daniel Dai Yu,Emily Millard,Wenxin Zhang,Cecilia de Heus,Christophe Queval,Javier H Hervás,Enrica Pellegrino,Ioanna Panagi,Ditte Fogde,Teresa L M Thurston,Judith Klumperman,Maximiliano Gutierrez,Sharon A Tooze
제품이 사용된 논문 모두 보기
style
left-column
style
left-column
style
right-column

Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com