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AB192481

Anti-APLP1 antibody

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(3 제품이 사용된 논문 )

Rabbit Polyclonal APLP1 antibody. Suitable for WB and reacts with Mouse samples. Cited in 3 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human APLP1.

대체 명칭 보기

Amyloid beta precursor like protein 1, Amyloid beta (A4) precursor-like protein 1, Amyloid-like protein 1, APLP, APLP-1, APLP1

1 이미지
Western blot - Anti-APLP1 antibody (AB192481)
  • WB

Supplier Data

Western blot - Anti-APLP1 antibody (AB192481)

All lanes:

Western blot - Anti-APLP1 antibody (ab192481) at 1/500 dilution

All lanes:

Mouse Brain lysate

Predicted band size: 72 kDa

Observed band size: 97 kDa

false

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human APLP1.

P51693

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보완 제품

Assay Kits

AB309112

Human APLP1 ELISA Kit - Extracellular

SimpleStep

Sandwich ELISA - Human APLP1 ELISA Kit - Extracellular (AB309112)

  • 0
  • 0
Primary Antibodies

AB181602

Anti-GAPDH antibody [EPR16891] - Loading Control

RabMAb|Recombinant|Lab Essentials|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GAPDH antibody [EPR16891] - Loading Control (AB181602)

  • 5
  • 23
Primary Antibodies

AB184411

Anti-P2Y12 antibody [EPR18611]

20ul selling size|RabMAb|Recombinant

Immunoprecipitation - Anti-P2Y12 antibody [EPR18611] (AB184411)

  • 1
  • 2
Primary Antibodies

AB281588

Anti-MAP2 antibody [RM1010] - Neuronal Marker

RabMAb|Recombinant|Lab Essentials|20ul selling size

Flow Cytometry (Intracellular) - Anti-MAP2 antibody [RM1010] - Neuronal Marker (AB281588)

  • 0
  • 0
Primary Antibodies

AB32136

Anti-Amyloid Precursor Protein antibody [Y188]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Amyloid Precursor Protein antibody [Y188] (AB32136)

  • 4
  • 9
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
Purification 관련 사항
purity is > 95% (by SDS-PAGE).
보관 버퍼
Preservative: 0.1% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

APLP1 also known as amyloid precursor-like protein 1 is a protein with a molecular mass of approximately 91 kDa. Researchers have observed its expression in the brain particularly in regions like the cortex and hippocampus. This protein shares structural similarities with the Amyloid Precursor Protein (APP) family and plays important roles in cellular functions through its protein domains and motifs.
Biological function summary

APLP1 functions by contributing to cell-cell adhesion and synaptic formation impacting neuronal development. It forms part of a larger protein complex that modulates these processes interacting with other proteins to maintain cellular communication. This protein's activity supports the stability and plasticity of synapses which is essential for proper neural network function.

Pathways

Proteins related to APLP1 participate notably in the Notch signaling and MAPK pathways. These pathways influence cell fate decisions growth and survival. APLP1 interacts with proteins such as APP and APLP2 both of which also engage in similar signaling pathways. This interconnectedness highlights APLP1's role in neurobiological processes essential for normal brain operation.

Researchers link APLP1 to neurodegenerative disorders like Alzheimer's disease and autism spectrum disorders. Changes in APLP1 expression or function can affect amyloidogenic processing connecting it to APP and potentially leading to plaque formation a hallmark of Alzheimer's disease. Additionally this protein's relationship with synaptic function may contribute to the pathophysiology observed in autism spectrum disorders where alterations in synaptic communication are common.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding (By similarity). Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I.. The gamma-CTF peptide, C30, is a potent enhancer of neuronal apoptosis.
See full target information APLP1
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제품이 사용된 논문 (3)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Science advances 11:eado6894 PubMed39742488

2025

Blood-derived APLP1 extracellular vesicles are potential biomarkers for the early diagnosis of brain diseases.

Applications

Unspecified application

Species

Unspecified reactive species

Yuri Choi,Jae Hyun Park,Ala Jo,Chul-Woo Lim,Ji-Min Park,Jin Woo Hwang,Kang Soo Lee,Young-Sang Kim,Hakho Lee,Jisook Moon

Science translational medicine 12: PubMed33239387

2020

Tau and other proteins found in Alzheimer's disease spinal fluid are linked to retromer-mediated endosomal traffic in mice and humans.

Applications

Unspecified application

Species

Unspecified reactive species

Sabrina Simoes,Jessica L Neufeld,Gallen Triana-Baltzer,Setareh Moughadam,Emily I Chen,Milankumar Kothiya,Yasir H Qureshi,Vivek Patel,Lawrence S Honig,Hartmuth Kolb,Scott A Small

The Journal of biological chemistry 291:21903-21912 PubMed27563067

2016

Alternative Processing of the Amyloid Precursor Protein Family by Rhomboid Protease RHBDL4.

Applications

Unspecified application

Species

Unspecified reactive species

Sandra Paschkowsky,Mehdi Hamzé,Felix Oestereich,Lisa Marie Munter
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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