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AB231523

Anti-Apolipoprotein L1/APOL1 antibody

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(2 제품이 사용된 논문 )

Rabbit Polyclonal Apolipoprotein L1/APOL1 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human APOL1 aa 1 to C-terminus.

대체 명칭 보기

APOL, APOL1, Apolipoprotein L1, Apolipoprotein L, Apolipoprotein L-I, Apo-L, ApoL, ApoL-I

3 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Apolipoprotein L1/APOL1 antibody (AB231523)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Apolipoprotein L1/APOL1 antibody (AB231523)

Paraffin-embedded human kidney tissue stained for Apolipoprotein L 1/APOL1 using ab231523 at 20 μg/ml in immunohistochemical analysis. DAB staining.

Western blot - Anti-Apolipoprotein L1/APOL1 antibody (AB231523)
  • WB

Supplier Data

Western blot - Anti-Apolipoprotein L1/APOL1 antibody (AB231523)

All lanes:

Western blot - Anti-Apolipoprotein L1/APOL1 antibody (ab231523) at 3 µg/mL

All lanes:

MCF7 (human breast adenocarcinoma cell line) cell lysate

Secondary

All lanes:

HRP-linked Guinea pig anti-Rabbit at 1/2000 dilution

Predicted band size: 15 kDa,44 kDa,49 kDa

false

Western blot - Anti-Apolipoprotein L1/APOL1 antibody (AB231523)
  • WB

Supplier Data

Western blot - Anti-Apolipoprotein L1/APOL1 antibody (AB231523)

All lanes:

Western blot - Anti-Apolipoprotein L1/APOL1 antibody (ab231523) at 5 µg/mL

All lanes:

Recombinant human Apolipoprotein L 1/APOL1 protein

Predicted band size: 44 kDa

false

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human APOL1 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

O14791

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대체품

Primary Antibodies

AB211462

Anti-Apolipoprotein L1/APOL1 antibody [CL0171]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Apolipoprotein L1/APOL1 antibody [CL0171] (AB211462)

  • 3
  • 1
Primary Antibodies

AB169952

Anti-Apolipoprotein L1/APOL1 antibody [EPR2907(2)] - BSA and Azide free

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-Apolipoprotein L1/APOL1 antibody [EPR2907(2)] - BSA and Azide free (AB169952)

  • 0
  • 0

보완 제품

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BOND RX™ Validated|KO Validated|RabMAb|Advanced Validation|Recombinant|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ki67 antibody [SP6] (AB16667)

  • 5
  • 133
Primary Antibodies

AB229327

Anti-LC3B antibody - N-terminal

Lab Essentials

Flow Cytometry - Anti-LC3B antibody - N-terminal (AB229327)

  • 0
  • 0
Primary Antibodies

AB183597

Anti-Apolipoprotein E antibody [EPR19392]

20ul selling size|RabMAb|Recombinant|KO Validated

Western blot - Anti-Apolipoprotein E antibody [EPR19392] (AB183597)

  • 0
  • 0
Primary Antibodies

AB52945

Anti-Apolipoprotein A I antibody [EP1368Y]

20ul selling size|RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-Apolipoprotein A I antibody [EP1368Y] (AB52945)

  • 4
  • 9
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-5 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-20 µg/mL", "IHCP-species-notes": "<p></p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
Purification 관련 사항
ab231523 was purified by antigen-specific affinity chromatography followed by Protein A affinity chromatography.
보관 버퍼
pH: 7.4 Preservative: 0.011% Proclin 300 Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Apolipoprotein L1 also known as APOL1 is a protein with a mass of approximately 42 kDa. It is primarily expressed in the liver but can also be found in various tissues including the placenta pancreas and kidney. As a part of the apolipoprotein family APOL1 contributes to lipid binding and transport processes. The protein is involved in innate immunity due to its ability to bind and kill certain trypanosomes which are parasites that can cause disease in humans.
Biological function summary

APOL1 functions as a component in lipid transport and immune response. It plays an important role in the lytic pathway against trypanosomes by forming a pore in their lysosomal membranes leading to cell death. While it does not form part of a larger complex its activity is important when interacting with other factors and lipids. APOL1's actions demonstrate an integral aspect of the body's defense system particularly with its influence on cellular structures through lipid interactions.

Pathways

APOL1 is involved in the regulation of lipid metabolism and immune response pathways. It plays a role in the high-density lipoprotein (HDL) particle remodeling pathway. Another significant pathway involving APOL1 is the APOL family protein pathway which includes related proteins like APOL2 and APOL3. These proteins collaboratively contribute to intracellular lipid transport and immune defense establishing an interconnected network among them.

There is a significant connection between APOL1 variants and chronic kidney disease (CKD) and non-diabetic forms of End-Stage Renal Disease (ESRD). The risk alleles of the APOL1 gene are associated with increased incidence of CKD especially in individuals of African descent. These associations highlight the interaction between APOL1 and renal pathology as well as its linkage to other proteins like MYH9 which also relate to kidney diseases. Understanding APOL1's role in these conditions may aid in developing targeted medical interventions.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver. A component of trypanosome lytic factor of human serum; plays a crucial role in killing Trypanosoma brucei by forming pores in parasite lysosomal membranes and sensitizing T.brucei to oxidation-stimulated osmotic lysis (PubMed : 12621437, PubMed : 16020735, PubMed : 19997494, PubMed : 26645690, PubMed : 7723792).
See full target information APOL1
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제품이 사용된 논문 (2)

Recent publications for all applications. Explore the 전체 목록 and refine your search

The Journal of clinical investigation 131: PubMed34499625

2021

Recipient APOL1 risk alleles associate with death-censored renal allograft survival and rejection episodes.

Applications

Unspecified application

Species

Unspecified reactive species

Zhongyang Zhang,Zeguo Sun,Jia Fu,Qisheng Lin,Khadija Banu,Kinsuk Chauhan,Marina Planoutene,Chengguo Wei,Fadi Salem,Zhengzi Yi,Ruijie Liu,Paolo Cravedi,Haoxiang Cheng,Ke Hao,Philip J O'Connell,Shuta Ishibe,Weijia Zhang,Steven G Coca,Ian W Gibson,Robert B Colvin,John Cijiang He,Peter S Heeger,Barbara Murphy,Madhav C Menon

Journal of vascular research 55:255-267 PubMed30179877

2018

Perfusion Tissue Culture Initiates Differential Remodeling of Internal Thoracic Arteries, Radial Arteries, and Saphenous Veins.

Applications

Unspecified application

Species

Unspecified reactive species

David A Prim,Vinal Menon,Shahd Hasanian,Laurel Carter,Tarek Shazly,Jay D Potts,John F Eberth
제품이 사용된 논문 모두 보기
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Product promise

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