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AB243487

Anti-AQP12 antibody

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(1 출판물)

Rabbit Polyclonal AQP12 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human AQP12A aa 200 to C-terminus.

대체 명칭 보기

AQP12, AQPX2, AQP12A, Putative aquaporin-12A, AQP-12

1 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AQP12 antibody (AB243487)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AQP12 antibody (AB243487)

Paraffin-embedded human pancreas tissue stained for AQP12 using ab243487 at 1/50 dilution in immunohistochemical analysis.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human AQP12A aa 200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q8IXF9

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보완 제품

Assay Kits

AB210905

ELISA Accessory Pack

  • 0
  • 0
Reagents, Controls & Accessories

AB171529

450 nm Stop Solution for TMB Substrate

  • 0
  • 0
Reagents, Controls & Accessories

AB210899

ELISA Coating Buffer 1X

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Primary Antibodies

AB108994

Anti-Stromal interaction molecule 1 antibody [EPR3414]

20ul selling size|RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Stromal interaction molecule 1 antibody [EPR3414] (AB108994)

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  • 1
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Aquaporin 12 (AQP12) is a member of the aquaporin water channel family sometimes referred to by the alternate name AQP12A. It has a molecular mass of approximately 34 kDa. It is expressed in specific tissues most notably in the pancreas and some parts of the immune system. AQP12 plays a critical role in transporting glycerol and water across cellular membranes which is essential for maintaining cellular osmotic balance.
Biological function summary

Aquaporin 12 is important in various cellular activities linked to fluid regulation and secretion processes particularly in pancreatic acinar cells. It is not part of any known larger protein complexes but works individually to facilitate water and glycerol transport. The expression patterns of AQP12 suggest it could play a critical role in exocrine functions particularly fluid secretion in pancreatic cells.

Pathways

Aquaporin 12 is associated with the water transport regulation pathway which regulates fluid balance in tissues. It has potential interactions with the glycerol transport pathway due to its dual capacity to transport water and glycerol. AQP12 might interact with other proteins such as aquaporin 7 (AQP7) known for its glycerol and water channel properties to modulate these pathways effectively.

Aquaporin 12 shows relevance in pancreatic disorders and diabetes. Its role in pancreatic fluid secretion links it to pancreatitis where disrupted fluid balance may occur. Additionally AQP12 may be involved in pathways affected by diabetes given its role in glycerol transport and is possibly linked with insulin-regulating proteins like GLUT2 which aids in glucose transport in pancreatic cells. These associations suggest that AQP12 could influence disease processes impacting pancreatic health and glucose metabolism.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Putative aquaporin. Could form homotetrameric transmembrane channels, with each monomer independently mediating water transport across the plasma membrane along its osmotic gradient.
See full target information AQP12A
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Journal of translational medicine 22:216 PubMed38424632

2024

Ubiquitylation of RUNX3 by RNA-binding ubiquitin ligase MEX3C promotes tumorigenesis in lung adenocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Zelai He,Huijun Zhang,Haibo Xiao,Xiangyu Zhang,Hongbo Xu,Ruifen Sun,Siwen Li
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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