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AB74454

Anti-ARHGAP17 antibody

4

(1 리뷰)

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(4 제품이 사용된 논문 )

Rabbit Polyclonal ARHGAP17 antibody. Suitable for WB and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human ARHGAP17 aa 300-400.
1 이미지
Western blot - Anti-ARHGAP17 antibody (AB74454)
  • WB

Unknown

Western blot - Anti-ARHGAP17 antibody (AB74454)

All lanes:

Western blot - Anti-ARHGAP17 antibody (ab74454) at 1/500 dilution

Lane 1:

extracts from LOVO cells at 15 µg

Lane 2:

extracts from LOVO cells at 15 µg with immunizing peptide

Predicted band size: 95 kDa

Observed band size: 95 kDa

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주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human ARHGAP17 aa 300-400. The exact immunogen used to generate this antibody is proprietary information.

Q68EM7

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보완 제품

Proteins & Peptides

AB132846

Recombinant Human ARHGAP17 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human ARHGAP17 protein (GST tag N-Terminus) (AB132846)

  • 0
  • 0
Primary Antibodies

AB263947

Anti-STAT6 (phospho Y641) antibody [EPR22599-78]

BOND RX™ Validated|RabMAb|Recombinant|20ul selling size

Flow Cytometry (Intracellular) - Anti-STAT6 (phospho Y641) antibody [EPR22599-78] (AB263947)

  • 5
  • 1
Primary Antibodies

AB238124

Anti-Caspase-4 antibody [EPR20921-83]

20ul selling size|RabMAb|Recombinant|KO Validated

Flow Cytometry (Intracellular) - Anti-Caspase-4 antibody [EPR20921-83] (AB238124)

  • 4
  • 1
Primary Antibodies

AB108333

Anti-Pro Caspase-8 antibody [EPR162]

20ul selling size|RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Pro Caspase-8 antibody [EPR162] (AB108333)

  • 4
  • 1
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

ARHGAP17 also known as Rho GTPase-activating protein 17 or by its popular alternate name Rich1 plays a significant role in regulating the Rho GTPase signaling pathway. It belongs to a group of proteins that convert active GTP-bound Rho GTPases to their inactive GDP-bound state. ARHGAP17 has a molecular weight of approximately 82 kDa. It is expressed in various tissues including the brain and the endothelial cells indicating its importance in diverse cellular environments.
Biological function summary

ARHGAP17 participates in cellular processes that require regulation of the actin cytoskeleton. It forms part of a larger complex that controls cell shape and movement by modulating cytoskeletal dynamics. By converting GTP-bound RhoA to its GDP-bound form ARHGAP17 directly affects cell morphology and polarity impacting processes like cell migration and adhesion.

Pathways

ARHGAP17 is actively involved in the Rho GTPase cycle which is critical for actin cytoskeleton reorganization. It intersects with the tight junction pathway where it influences cell-cell adhesion and maintains epithelial cell integrity. ARHGAP17 interacts with proteins such as Cdc42 enhancing its capacity to regulate cellular architecture and function within these pathways.

ARHGAP17 has been associated with conditions like cancer and cardiovascular disease. Aberrant expression or mutations of ARHGAP17 can lead to disruptions in cell polarity and uncontrolled cell proliferation contributing to tumor development. Moreover its role in maintaining endothelial cell junctions links it to cardiovascular disorders where it interacts with proteins like VE-cadherin to regulate vascular integrity.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1.
See full target information ARHGAP17

대체 명칭 보기

RICH1, MSTP066, MSTP110, ARHGAP17, Rho GTPase-activating protein 17, Rho-type GTPase-activating protein 17, RhoGAP interacting with CIP4 homologs protein 1, RICH-1
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제품이 사용된 논문 (4)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Neoplasma 69:640-647 PubMed35293764

2022

ARHGAP17 enhances 5-Fluorouracil-induced apoptosis in colon cancer cells by suppressing Rac1.

Applications

Unspecified application

Species

Unspecified reactive species

Sheng-Li Pan,Ying-Ying Deng,Jun Fu,Yu-Hao Zhang,Zhi-Jin Zhang,Xian-Ju Qin

Clinical and experimental pharmacology & physiology 47:1591-1599 PubMed32391922

2020

ARHGAP17 inhibits pathological cyclic strain-induced apoptosis in human periodontal ligament fibroblasts via Rac1/Cdc42.

Applications

Unspecified application

Species

Unspecified reactive species

Li Wang,Xiaojie Yang,Leilei Wan,Shiwei Wang,Jinsong Pan,Yuehua Liu

Journal of cellular biochemistry 120:439-451 PubMed30216523

2018

Suppression of BMX-ARHGAP fusion gene inhibits epithelial-mesenchymal transition in gastric cancer cells via RhoA-mediated blockade of JAK/STAT axis.

Applications

Unspecified application

Species

Unspecified reactive species

Xiao-Feng Xu,Jian-Jiang Wang,Li Ding,Jin-Song Ye,Li-Juan Huang,Lan Tao,Feng Gao,Yong Ji

The Journal of biological chemistry 290:29974-83 PubMed26507661

2015

Cyclic Nucleotide-dependent Protein Kinases Target ARHGAP17 and ARHGEF6 Complexes in Platelets.

Applications

Unspecified application

Species

Unspecified reactive species

Zoltan Nagy,Kieran Wynne,Alexander von Kriegsheim,Stepan Gambaryan,Albert Smolenski
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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