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AB121617

Anti-ARHGAP23 antibody

4

(1 리뷰)

|

(1 출판물)

Rabbit Polyclonal ARHGAP23 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ARHGAP23 aa 500-600.

대체 명칭 보기

KIAA1501, ARHGAP23, Rho GTPase-activating protein 23, Rho-type GTPase-activating protein 23

1 이미지
Immunocytochemistry/ Immunofluorescence - Anti-ARHGAP23 antibody (AB121617)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-ARHGAP23 antibody (AB121617)

Immunofluorescent staining of Human cell line U-251MG shows positivity in nucleus but not nucleoli and plasma membrane. Recommended concentration of ab121617 1-4 µg/ml. Cells treated with PFA/Triton X-100.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human ARHGAP23 aa 500-600. The exact immunogen used to generate this antibody is proprietary information.

Q9P227

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보완 제품

Primary Antibodies

AB224413

Anti-RAP1GDS1 antibody

Immunocytochemistry/ Immunofluorescence - Anti-RAP1GDS1 antibody (AB224413)

  • 0
  • 0
Primary Antibodies

AB182570

Anti-GARNL1 antibody [EPR13592-38]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GARNL1 antibody [EPR13592-38] (AB182570)

  • 0
  • 0
Primary Antibodies

AB101371

Anti-Ube2G1 antibody

Western blot - Anti-Ube2G1 antibody (AB101371)

  • 0
  • 0
Primary Antibodies

AB171947

Anti-SKAP55 antibody [EPR11359]

RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-SKAP55 antibody [EPR11359] (AB171947)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

ARHGAP23 also known as Rho GTPase-activating protein 23 is a member of the RhoGAP family of proteins. It plays an important role in regulating Rho protein signaling by converting active GTP-bound Rho proteins into their inactive GDP-bound state. The molecular mass of ARHGAP23 is approximately 183 kDa. It is mainly expressed in various tissues including the brain and liver indicating its important role in cellular activities across different organ systems.
Biological function summary

ARHGAP23 acts as a critical regulator of cytoskeletal dynamics and cellular morphology. It functions as part of a complex that modulates actin filament organization which is essential for cell movement and proliferation. Through its interactions it influences the cellular response to external stimuli impacting processes such as cell migration and adhesion which are important in tissue development and repair.

Pathways

ARHGAP23 is a significant component of the Rho signaling pathway where it works to control cytoskeletal rearrangements. It interacts with other proteins like RhoA and Cdc42 coordinating their activity to ensure precise regulation of cytoskeletal structures. Additionally its involvement in the signaling cascade affects the MAPK pathway with implications for cellular growth and differentiation.

ARHGAP23 alterations can be associated with certain types of cancers and neurodegenerative disorders. Changes in its expression or function can disrupt normal cell-cell adhesion and cytoskeletal organization contributing to the progression of malignant tumors. In the context of neurodegeneration its interaction with proteins like Rac1 may influence neuronal survival and function potentially linking it to disorders such as Alzheimer's disease.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.
See full target information ARHGAP23
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Journal of cardiothoracic surgery 20:51 PubMed39780196

2025

SNX30 inhibits lung adenocarcinoma cell proliferation and induces cell ferroptosis through regulating SETDB1.

Applications

Unspecified application

Species

Unspecified reactive species

Xinjie Fan,Qichu Zhu,Chengzhuo Du,Jinlai Chen,Yingming Su
제품이 사용된 논문 모두 보기
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Product promise

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