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AB237631

Anti-ARL6IP2 antibody

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Rabbit Polyclonal ARL6IP2 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ATL2 aa 1-300.

대체 명칭 보기

ARL6IP2, ATL2, Atlastin-2, ATL-2, ADP-ribosylation factor-like protein 6-interacting protein 2

1 이미지
Immunocytochemistry/ Immunofluorescence - Anti-ARL6IP2 antibody (AB237631)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-ARL6IP2 antibody (AB237631)

HepG2 (human liver hepatocellular carcinoma cell line) cells stained for ARL6IP2 (green) using ab237631 at 1/100 dilution in ICC/IF, followed by Alexa Fluor 488® conjugated Goat Anti-Rabbit IgG (H+L) secondary antibody.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, WB

applications

Immunogen

Recombinant Fragment Protein within Human ATL2 aa 1-300. The exact immunogen used to generate this antibody is proprietary information.

Q8NHH9

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대체품

Primary Antibodies

AB224825

Anti-ARL6IP2 antibody

Immunoprecipitation - Anti-ARL6IP2 antibody (AB224825)

  • 0
  • 0

보완 제품

Primary Antibodies

AB22595

Anti-Calnexin antibody - ER Marker

Lab Essentials|KO Validated

Immunocytochemistry/ Immunofluorescence - Anti-Calnexin antibody - ER Marker (AB22595)

  • 5
  • 28
Primary Antibodies

AB117819

Anti-ATL3 antibody

Immunoprecipitation - Anti-ATL3 antibody (AB117819)

  • 5
  • 1
Primary Antibodies

AB52649

Anti-GM130 antibody [EP892Y] - cis-Golgi Marker

RabMAb|Recombinant|Lab Essentials|20ul selling size

Immunoprecipitation - Anti-GM130 antibody [EP892Y] - cis-Golgi Marker (AB52649)

  • 5
  • 39
Primary Antibodies

AB92516

Anti-Calreticulin antibody [EPR3924] - ER Marker

20ul selling size|BOND RX™ Validated|RabMAb|Recombinant|KO Validated|Lab Essentials

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Calreticulin antibody [EPR3924] - ER Marker (AB92516)

  • 4
  • 6
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein G
Purification 관련 사항
Purity greater than 95%.
보관 버퍼
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

ARL6IP2 also known as ADP-ribosylation-like factor 6 interacting protein 2 is a protein involved in various cellular processes. It has a mass of approximately 25 kDa and is expressed in the endoplasmic reticulum. This protein interacts with lipid-raft-associated proteins playing an important role in membrane dynamics and vesicular trafficking. Researchers have observed it in tissues that exhibit high secretory activity which suggests a function associated with protein transport or modification processes within the cell.
Biological function summary

ARL6IP2 interacts with components of the endoplasmic reticulum to maintain cellular homeostasis and structural integrity. It may be part of larger protein complexes involved in intracellular transport. This protein aids in regulating vesicle formation and trafficking which are essential for efficient cellular communication and nutrient delivery. Its ability to reorganize membrane components allows cells to respond to environmental changes effectively facilitating adaptive responses and cellular survival.

Pathways

ARL6IP2 plays a role in the endocytic and secretory pathways. It works alongside other proteins like ARF proteins and clathrin orchestrating trafficking processes that modulate membrane composition and vesicle transport. These pathways are important for normal cellular functioning and involve coordinated interactions with multiple proteins to maintain cellular equilibrium. ARL6IP2's role in these pathways exemplifies its importance in cellular dynamics and intracellular signaling.

Studies suggest links between ARL6IP2 and certain neurodegenerative conditions and cancer. Research indicates alterations in ARL6IP2 expression levels might contribute to the progression of diseases like Alzheimer's due to its involvement in cellular trafficking and membrane stability. The protein's connection to disorders often involves interactions with other proteins such as beta-amyloid precursor protein in Alzheimer's indicating its roles in disease mechanisms and pathogenesis. Understanding these interactions provides insights into developing strategies for therapeutic interventions.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Atlastin-2 (ATL2) is a membrane-anchored GTPase that mediates the GTP-dependent fusion of endoplasmic reticulum (ER) membranes, maintaining the continuous ER network. It facilitates the formation of three-way junctions where ER tubules intersect (PubMed : 18270207, PubMed : 19665976, PubMed : 22065636, PubMed : 27619977, PubMed : 34817557). Two atlastin-2 on neighboring ER tubules bind GTP and form loose homodimers through the GB1/RHD3-type G domains and 3HB regions. Upon GTP hydrolysis, the 3HB regions tighten, pulling the membranes together to drive their fusion. After fusion, the homodimer disassembles upon release of inorganic phosphate (Pi). Subsequently, GDP dissociates, resetting the monomers to a conformation ready for a new fusion cycle (By similarity).
See full target information ATL2
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Molecular and cellular biochemistry 477:649-661 PubMed34870753

2021

MiR-1246 regulates the PI3K/AKT signaling pathway by targeting PIK3AP1 and inhibits thyroid cancer cell proliferation and tumor growth.

Applications

Unspecified application

Species

Unspecified reactive species

Jingyan Li,Zhanlei Zhang,Jieting Hu,Xiaoting Wan,Wei Huang,Hong Zhang,Ningyi Jiang
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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