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AB235421

Anti-Arpin antibody

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(2 제품이 사용된 논문 )

Rabbit Polyclonal ARPIN antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ARPIN aa 1 to C-terminus.

대체 명칭 보기

C15orf38, ARPIN, Arpin, Arp2/3 inhibition protein

2 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Arpin antibody (AB235421)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Arpin antibody (AB235421)

Paraffin-embedded human colon cancer tissue stained for Arpin using ab235421 at 1/100 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Arpin antibody (AB235421)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Arpin antibody (AB235421)

Paraffin-embedded human kidney tissue stained for Arpin using ab235421 at 1/100 dilution in immunohistochemical analysis.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human ARPIN aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q7Z6K5

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보완 제품

Primary Antibodies

AB125011

Anti-TSG101 antibody [EPR7130(B)]

20ul selling size|BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry - Anti-TSG101 antibody [EPR7130(B)] (AB125011)

  • 4
  • 10
Primary Antibodies

AB237456

Alexa Fluor® 647 Anti-NCAM1 antibody [EP2567Y]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Alexa Fluor® 647 Anti-NCAM1 antibody [EP2567Y] (AB237456)

  • 0
  • 0
Biochemicals

AB141231

CK 666, Actin polymerization inhibitor

Chemical Structure - CK 666, Actin polymerization inhibitor (AB141231)

  • 0
  • 0
Primary Antibodies

AB242068

violetFluor™ 450 Anti-CD127 antibody [A7R34]

Flow Cytometry - violetFluor™ 450 Anti-CD127 antibody [A7R34] (AB242068)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein G
Purification 관련 사항
Purity >95%
보관 버퍼
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Arpin also known as the Arp2/3 complex inhibitor plays an important role in actin dynamics. Mechanically Arpin acts by inhibiting the Arp2/3 complex which is essential for the nucleation of new actin filaments. This inhibition affects cell motility and migration. Arpin has a molecular mass of approximately 20 kDa and is ubiquitously expressed in various tissues including epithelial and nerve cells.
Biological function summary

Arpin regulates cell motility by controlling the formation of branched actin networks impacting processes like cell shape and movement. Arpin is not part of a larger protein complex but directly interacts with the Arp2/3 complex. Through this interaction it modulates the cytoskeleton's dynamic rearrangement affecting cellular responses to environmental signals.

Pathways

The inhibition of actin nucleation by Arpin influences the WAVE regulatory complex (WRC) and integrin signaling. These pathways are important for cell migration and adhesion. Arpin affects proteins such as Rac1 which is a part of the WRC pathway altering the actin network and impacting cell behavior.

Arpin's regulation of actin dynamics connects it to cancer metastasis and neurodegenerative conditions. Dysregulation of Arpin can lead to abnormal cell migration contributing to cancer spread. Additionally its role in actin polymerization links it to proteins like cofilin associated with neurodegenerative diseases due to cytoskeletal disruptions.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors. Participates in an incoherent feedforward loop at the lamellipodium tip where it inhibits the ARP2/2 complex in response to Rac signaling and where Rac also stimulates actin polymerization through the WAVE complex. Involved in steering cell migration by controlling its directional persistence.
See full target information ARPIN
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제품이 사용된 논문 (2)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Molecules and cells 46:351-359 PubMed36921992

2023

RNA Editing Enzyme ADAR1 Suppresses the Mobility of Cancer Cells via ARPIN.

Applications

Unspecified application

Species

Unspecified reactive species

Min Ji Park,Eunji Jeong,Eun Ji Lee,Hyeon Ji Choi,Bo Hyun Moon,Keunsoo Kang,Suhwan Chang

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology 45:769-775 PubMed30416079

2018

Arpin downregulation is associated with poor prognosis in pancreatic ductal adenocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Shi-Rong Zhang,Hao Li,Wen-Quan Wang,Wei Jin,Jin-Zhi Xu,Hua-Xiang Xu,Chun-Tao Wu,He-Li Gao,Shuo Li,Tian-Jiao Li,Wu-Hu Zhang,Shuai-Shuai Xu,Quan-Xing Ni,Xian-Jun Yu,Liang Liu
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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