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AB85727

Anti-ARSB antibody

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(1 출판물)

Goat Polyclonal ARSB antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human ARSB.
2 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ARSB antibody (AB85727)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ARSB antibody (AB85727)

ab85727, at 5 μg/ml, staining ARSB in skeletal muscle tissue by Immunohistochemistry.

Western blot - Anti-ARSB antibody (AB85727)
  • WB

Unknown

Western blot - Anti-ARSB antibody (AB85727)

All lanes:

Western blot - Anti-ARSB antibody (ab85727) at 0.03 µg/mL

All lanes:

human heart lysate at 35 µg

Predicted band size: 60 kDa

Observed band size: 35 kDa,40 kDa

false

주요 정보

Host species

Goat

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Synthetic Peptide within Human ARSB. The exact immunogen used to generate this antibody is proprietary information.

P15848

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대체품

Primary Antibodies

AB228018

Anti-ARSB antibody

Western blot - Anti-ARSB antibody (AB228018)

  • 0
  • 0

보완 제품

Assay Kits

AB277466

Human ARSB ELISA Kit

ELISA - Human ARSB ELISA Kit (AB277466)

  • 0
  • 0
Primary Antibodies

AB187516

Anti-GALNS/Chondroitinase antibody

Western blot - Anti-GALNS/Chondroitinase antibody (AB187516)

  • 0
  • 0
Primary Antibodies

AB272648

Anti-IDUA antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IDUA antibody (AB272648)

  • 0
  • 0
Primary Antibodies

AB195234

Anti-TPP1 antibody [EPR16537]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TPP1 antibody [EPR16537] (AB195234)

  • 3
  • 2
Primary Antibodies

AB154177

Anti-GNS antibody [EPR8329(2)]

RabMAb|Recombinant|KO Validated

Western blot - Anti-GNS antibody [EPR8329(2)] (AB154177)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.03-0.1 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: Tris buffered saline, 0.5% BSA
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

The ARSB protein also known as arylsulfatase B or N-acetylgalactosamine-4-sulfatase is an enzyme weighing approximately 62 kDa. It plays a role in breaking down glycosaminoglycans in the lysosomes. ARSB is highly expressed in tissues such as the liver kidney and skin where its enzymatic activity is important for normal cellular metabolism.
Biological function summary

ARSB functions in the degradation of dermatan sulfate and chondroitin sulfate types of glycosaminoglycans. It works as a monomer and is not part of a larger protein complex. This enzyme targets specific sulfated molecules facilitating their breakdown and recycling within the lysosomes.

Pathways

ARSB is actively involved in the lysosomal degradation pathway one of the key cellular processes for waste removal and recycling of macromolecules. This pathway includes collaboration with other lysosomal enzymes such as iduronate-2-sulfatase to complete the breakdown of complex molecules. ARSB's function in coordination with these enzymes supports cellular maintenance and metabolic balance.

ARSB malfunction is directly linked to the lysosomal storage disorder Mucopolysaccharidosis VI (Maroteaux-Lamy syndrome) characterized by the accumulation of glycosaminoglycans. This deficiency can lead to several symptoms including skeletal abnormalities and organomegaly. ARSB has also shown relevance in some inflammatory disorders where alterations in glycosaminoglycan breakdown impact cellular communication and tissue homeostasis.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation (PubMed : 19306108). Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (PubMed : 19306108). In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity).
See full target information ARSB

대체 명칭 보기

Arylsulfatase B, ASB, N-acetylgalactosamine-4-sulfatase, G4S, ARSB
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Osteoarthritis and cartilage 22:986-95 PubMed24857976

2014

Changes in the metabolism of chondroitin sulfate glycosaminoglycans in articular cartilage from patients with Kashin-Beck disease.

Applications

Unspecified application

Species

Unspecified reactive species

M Luo,J Chen,S Li,H Sun,Z Zhang,Q Fu,J Li,J Wang,C E Hughes,B Caterson,J Cao
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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