AB47092

Anti-ASC2/ASCI antibody

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(22 제품이 사용된 논문 )

Rabbit Polyclonal ASC2/ASCI antibody. Suitable for WB, IHC-P and reacts with Human, Mouse samples. Cited in 22 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human PYDC1.

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ASC2/ASCI antibody (AB47092)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ASC2/ASCI antibody (AB47092)

Immunhistochemical analysis of ASC2/ASCI/POP1 expression in mouse spleen using ab47092 at 1 : 2000. Left and Right images : spleen at low and high magnification, respectively. ASC2/ASCI/POP1 staining is seen in the granulocytes, whereas the lymph and megakaryocytes are negative.

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ASC2/ASCI antibody (AB47092)

Immunhistochemical analysis of ASC2/ASCI/POP1 expression in mouse using ab47092 at 1 : 2000. A, prostate tissue from a male mouse prostatitis. B, kidney from a mouse with pyelonephritis. A1 and B1, high magnification of A and B, respectively. ASC2/ASCI/POP1 staining is seen in the granulocytes

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse, Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human PYDC1.

Q8WXC3

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/2000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Mouse": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" } } }

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특성 및 보관 정보

제형

Liquid

Purity

Whole antiserum

보관 버퍼

Preservative: 0.05% Sodium azide Constituents: Whole serum

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

The ASC2/ASCI protein also known as nuclear receptor coactivator 7 (NCOA7) is an intracellular protein with a mass of approximately 87 kDa. It is mainly expressed in the brain pancreas and testis indicating its significant roles in these tissues. ASC2 acts as a transcriptional coactivator by enhancing the transcriptional activities of steroid hormone receptors and nuclear receptors. Through its coactivator functions ASC2 interacts with other proteins in the nucleus to help regulate the transcription of specific genes.

Biological function summary

ASC2 contributes as a part of the larger coactivator complex that enhances gene transcription. It interacts with nuclear receptors to potentiate their ability to bind DNA and influence gene expression. This protein also engages in direct protein-protein interactions with other transcription factors such as ASCOM components facilitating a range of cellular functions. ASC2's presence in multiple tissues suggests its involvement in diverse biological processes including cellular growth and differentiation.

Pathways

ASC2 plays a role in important signal transduction pathways such as the nuclear receptor signaling pathway. It works alongside proteins like estrogen receptor and androgen receptor which are integral to the regulation of genes involved in cellular homeostasis and metabolism. ASC2 as part of the larger transcriptional machinery assists in fine-tuning the expression of genes in response to hormonal signals and environmental cues.

ASC2 has been linked to neurodegenerative diseases like Alzheimer's disease and certain types of cancer. In Alzheimer's disease the interaction of ASC2 with estrogen receptors can influence amyloid beta clearance affecting disease progression. In cancers ASC2’s ability to amplify nuclear receptor activities suggests its involvement in tumor growth dynamics. Its interactions with coactivators in these disorders make ASC2 a target of interest for therapeutic intervention.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Associates with PYCARD/ASC and modulates its ability to collaborate with MEFV/pyrin and NLRP3/cryopyrin in NF-kappa-B and pro-caspase-1 activation. Suppresses kinase activity of NF-kappa-B inhibitor kinase (IKK) complex, expression of NF-kappa-B inducible genes and inhibits NF-kappa-B activation by cytokines and LPS.

See full target information PYDC1

대체 명칭 보기

ASC2, ASCI, POP1, PYC1, PYDC1, Pyrin domain-containing protein 1, PAAD-only protein 1, Pyrin-only protein 1, cellular POP1, cPOP1

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제품이 사용된 논문 (22)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Heliyon 10:e30240 PubMed38726105

2024

Calycosin prevents NLRP3-induced gut fibrosis by regulating IL-33/ST2 axis.

Applications

Unspecified application

Species

Unspecified reactive species

Xiujun Liao,Haiting Xie,Saojun Yu

Journal of diabetes research 2023:7423661 PubMed37261217

2023

Astragaloside IV Attenuates High-Glucose-Induced Impairment in Diabetic Nephropathy by Increasing Klotho Expression via the NF-B/NLRP3 Axis.

Applications

Unspecified application

Species

Unspecified reactive species

Jiaxin He,Jialin Cui,Yimin Shi,Tao Wang,Junyan Xin,Yimeng Li,Xiaomeng Shan,Zhiyao Zhu,Yanbin Gao

Journal of molecular neuroscience : MN 72:2389-2397 PubMed36441377

2022

VX-765 Alleviates β-Amyloid Deposition and Secondary Degeneration in the Ipsilateral Hippocampus and Ameliorates Cognitive Decline after Focal Cortical Infarction in Rats.

Applications

Unspecified application

Species

Unspecified reactive species

Dawei Dong,Aihui Ren,Ying Yang,Jiayi Su,Libin Liu,Wenyan Zhuo,Yubin Liang

Phytotherapy research : PTR 37:15-34 PubMed36054406

2022

Nigakinone alleviates DSS-induced experimental colitis via regulating bile acid profile and FXR/NLRP3 signaling pathways.

Applications

Unspecified application

Species

Unspecified reactive species

Fangle Liu,Yufeng Yao,Qian Wang,Fengxue Zhang,Meiqi Wang,Chenchen Zhu,Chaozhan Lin

Oxidative medicine and cellular longevity 2022:8659587 PubMed35602094

2022

MicroRNA-299a-5p Protects against Spinal Cord Injury through Activating AMPK Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Zong-Ze Zhang,Shu-Yue Xian,Chong Bao,Feng Chen

Cell death discovery 7:337 PubMed34743181

2021

LPS-induced macrophage HMGB1-loaded extracellular vesicles trigger hepatocyte pyroptosis by activating the NLRP3 inflammasome.

Applications

Unspecified application

Species

Unspecified reactive species

Guozhen Wang,Siyi Jin,Weichang Huang,Yang Li,Jun Wang,Xuguang Ling,Yun Huang,Ye Hu,Congcong Li,Ying Meng,Xu Li

The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 25:533-543 PubMed34697264

2021

Triptolide improves myocardial fibrosis in rats through inhibition of nuclear factor kappa B and NLR family pyrin domain containing 3 inflammasome pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Jianyao Shen,Hailiang Ma,Chaoquan Wang

Experimental and therapeutic medicine 22:1174 PubMed34504619

2021

Gardnerella vaginalis induces NLRP3 inflammasome-mediated pyroptosis in macrophages and THP-1 monocytes.

Applications

Unspecified application

Species

Unspecified reactive species

Nan Xiang,Ting Yin,Tao Chen

Oxidative medicine and cellular longevity 2021:9942557 PubMed34422215

2021

MicroRNA-23a-5p Is Involved in the Regulation of Lipopolysaccharide-Induced Acute Lung Injury by Targeting HSP20/ASK1.

Applications

Unspecified application

Species

Unspecified reactive species

Yi-Fei Chen,Fen Hu,Xian-Guo Wang,Zheng Tang,He-Xiao Tang,Ming Xu

Frontiers in cellular neuroscience 14:540669 PubMed33584203

2021

Inhibition of Caspase-1 Ameliorates Ischemia-Associated Blood-Brain Barrier Dysfunction and Integrity by Suppressing Pyroptosis Activation.

Applications

Unspecified application

Species

Unspecified reactive species

Yubin Liang,Pingping Song,Wei Chen,Xuemin Xie,Rixin Luo,Jiehua Su,Yunhui Zhu,Jiamin Xu,Rongrong Liu,Peizhi Zhu,Yusheng Zhang,Min Huang

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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Anti-ASC2/ASCI antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ASC2/ASCI antibody (AB47092)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ASC2/ASCI antibody (AB47092)

주요 정보

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Purity

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 기간

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

대체 명칭 보기

제품이 사용된 논문 (22)

Product promise