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AB204348

Anti-ASCT-1 antibody

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Rabbit Polyclonal ASCT-1 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SLC1A4 aa 450 to C-terminus.

대체 명칭 보기

ASCT1, SATT, SLC1A4, Neutral amino acid transporter A, Alanine/serine/cysteine/threonine transporter 1, Solute carrier family 1 member 4, ASCT-1

2 이미지
Immunocytochemistry/ Immunofluorescence - Anti-ASCT-1 antibody (AB204348)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-ASCT-1 antibody (AB204348)

Immunofluorescent analysis of PFA-fixed, Triton X-100 permeabilized A431 cells labeling ASCT-1 with ab204348 at 4 μg/ml (green).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ASCT-1 antibody (AB204348)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ASCT-1 antibody (AB204348)

Immunohistochemical analysis of paraffin-embedded Human oral mucosa tissue labeling ASCT-1 with ab204348 at 1/20 dilution.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human SLC1A4 aa 450 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

P43007

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대체품

Primary Antibodies

AB189126

Anti-ASCT-1 antibody - C-terminal

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ASCT-1 antibody - C-terminal (AB189126)

  • 0
  • 0

보완 제품

Primary Antibodies

AB172730

Rabbit IgG, monoclonal [EPR25A] - Isotype Control

RabMAb|Advanced Validation|Recombinant

Flow Cytometry - Rabbit IgG, monoclonal [EPR25A] - Isotype Control (AB172730)

  • 0
  • 0
Primary Antibodies

AB229623

Anti-cxcr4b antibody - N-terminal

Western blot - Anti-cxcr4b antibody - N-terminal (AB229623)

  • 4
  • 1
Primary Antibodies

AB313454

Anti-EAAT2 antibody [RP23040136]

Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-EAAT2 Antibody [RP23040136] (AB313454)

  • 0
  • 0
Primary Antibodies

AB236519

Anti-SOCS3 antibody [OTI3D3]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SOCS3 antibody [OTI3D3] (AB236519)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/50", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

The Alanine Serine Cysteine-preferring Transporter 1 (ASCT-1) also known as SLC1A4 functions as a Na+-dependent transport protein for neutral amino acids including alanine serine and cysteine. It has a molecular mass of approximately 56 kDa. ASCT-1 expresses on the plasma membrane and is found in the brain and the retina. Its role in the transport of certain amino acids is critical for maintaining normal cellular functions and metabolic processes.
Biological function summary

ASCT-1 transports amino acids which contributes to cellular nutrition and neurotransmitter cycling. It does not function as part of a larger protein complex but rather as a standalone transporter. ASCT-1 plays a significant role in neuronal health by regulating amino acids in the synaptic cleft which impacts neurotransmitter synthesis and recycling essential for proper neural communication.

Pathways

ASCT-1 is actively involved in the glutamate cycle which maintains neurotransmitter homeostasis in the brain. Its activity facilitates the uptake of serine used in the synthesis of D-serine an important co-agonist in NMDA receptor pathways. Both the ASCT-2 transporter and SLC1A3 also part of the glutamate transporter family share related functions in these pathways ensuring the synaptic glutamate levels are regulated effectively.

ASCT-1 mutations or dysregulation have links to neurodevelopmental disorders including intellectual disability and epilepsy. Alterations in its function disrupt amino acid transport which can affect neurotransmitter cycling contributing to these conditions. Additionally ASCT-1 shares a connection with SLC1A5 in these disorders where overlapping functions in amino acid transport may exacerbate the symptoms when mutated or dysfunctional.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Sodium-coupled antiporter of neutral amino acids. In a tri-substrate transport cycle, exchanges neutral amino acids between the extracellular and intracellular compartments, coupled to the inward cotransport of at least one sodium ion (PubMed : 24808181, PubMed : 27272177, PubMed : 34630942, PubMed : 8910405). Exchanges neutral amino acids such as L- and D-serine, L-threonine, L-asparagine and L-alanine in a bidirectional way (PubMed : 14502423, PubMed : 26041762, PubMed : 27272177, PubMed : 34630942, PubMed : 8101838, PubMed : 8340364, PubMed : 8910405). Involved in homeostasis of D-serine, a coagonist of synaptic NMDA receptors. In astrocytes at excitatory synapses, mediates electrogenic D-serine influx coupled to L-serine efflux and L-serine shuttling to neurons for de novo D-serine synthesis (By similarity). Displays sodium- and amino acid-dependent but uncoupled channel-like anion conductance with a preference SCN(-) > NO3(-) > I(-) > Cl(-) (PubMed : 8910405).
See full target information SLC1A4
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

International journal of molecular sciences 24: PubMed36769360

2023

Haploinsufficiency Impairs PI3K/AKT/mTOR/Autophagy Pathway in Human Pluripotent Stem Cells Derived Neural Stem Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Junwen Wang,Ziyi Wang,Limeng Dai,Xintong Zhu,Xingying Guan,Junyi Wang,Jia Li,Mao Zhang,Yun Bai,Hong Guo
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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