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AB237611

Anti-ATP6V0A1 antibody

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Rabbit Polyclonal ATP6V0A1 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ATP6V0A1 aa 50-300.

대체 명칭 보기

ATP6N1, ATP6N1A, VPP1, ATP6V0A1, V-type proton ATPase 116 kDa subunit a 1, V-ATPase 116 kDa subunit a 1, Clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit, Vacuolar adenosine triphosphatase subunit Ac116, Vacuolar proton pump subunit 1, Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1

2 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ATP6V0A1 antibody (AB237611)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ATP6V0A1 antibody (AB237611)

Paraffin-embedded human kidney tissue stained for ATP6V0A1 using ab237611 at 1/100 dilution in immunohistochemical analysis.

Immunocytochemistry/ Immunofluorescence - Anti-ATP6V0A1 antibody (AB237611)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-ATP6V0A1 antibody (AB237611)

A549 (human lung carcinoma cell line) cells stained for ATP6V0A1 (green) using ab237611 at 1/100 dilution in ICC/IF, followed by Alexa Fluor 488® conjugated Goat Anti-Rabbit IgG (H+L).

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human ATP6V0A1 aa 50-300. The exact immunogen used to generate this antibody is proprietary information.

Q93050

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보완 제품

Primary Antibodies

AB157458

Anti-ATP6V1D antibody [EPR11326(B)]

RabMAb|Recombinant|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ATP6V1D antibody [EPR11326(B)] (AB157458)

  • 0
  • 0
Primary Antibodies

AB199326

Anti-ATP6V1A antibody [EPR19270]

RabMAb|Recombinant|20ul selling size

Immunocytochemistry/ Immunofluorescence - Anti-ATP6V1A antibody [EPR19270] (AB199326)

  • 4
  • 2
Primary Antibodies

AB202899

Anti-ATP6V0D1/P39 antibody [EPR18320-38]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ATP6V0D1/P39 antibody [EPR18320-38] (AB202899)

  • 0
  • 0
Primary Antibodies

AB96803

Anti-ATP6V0A2 antibody

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein G
Purification 관련 사항
Purity greater than 95%.
보관 버퍼
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

ATP6V0A1 also known as a subunit of the V0 domain of the vacuolar ATPase (V-ATPase) is a transmembrane protein involved in the acidification of intracellular compartments. It forms a component of the proton channel within the V-ATPase. This protein weighs approximately 95 kDa and can be found expressed in many tissues such as the kidney brain and liver. Its mechanical role involves contributing to proton translocation across cell membranes which is essential for various cellular activities.
Biological function summary

The protein participates in the ATP-dependent acidification of organelles like lysosomes and endosomes. As a part of a multi-subunit V-ATPase complex ATP6V0A1 helps maintain cellular pH balance and is essential for processes such as protein degradation and receptor-mediated endocytosis. Its activity influences the function of numerous cellular processes including ion transport and neurotransmitter release by regulating the pH in synaptic vesicles.

Pathways

ATP6V0A1 is involved in essential biological pathways such as the endocytic pathway and the lysosomal degradation pathway. Within these pathways V-ATPase in which ATP6V0A1 is a component interacts with several important proteins like ClC-5 which is involved in chloride ion transport. These interactions ensure the maintenance of the acidic environment necessary for enzyme activity and substrate processing within lysosomes and endosomes.

Mutations or dysfunction in ATP6V0A1 associate with pathologies such as osteoporosis and some forms of tumour growth. Abnormal activity of V-ATPase with connection to ATP6V0A1 may influence cancer cell behavior by altering the acidic microenvironment impacting cell invasion and metastasis. Additionally relationship with proteins like mTOR important in regulating cell growth and metabolism highlights its importance in disease development highlighting its potential as a therapeutic target.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that transports protons across cellular membranes. V-ATPase is responsible for the acidification of various organelles, such as lysosomes, endosomes, the trans-Golgi network, and secretory granules, including synaptic vesicles (PubMed : 33065002, PubMed : 33833240, PubMed : 34909687). In certain cell types, can be exported to the plasma membrane, where it is involved in the acidification of the extracellular environment (By similarity). Required for assembly and activity of the vacuolar ATPase (By similarity). Through its action on compartment acidification, plays an essential role in neuronal development in terms of integrity and connectivity of neurons (PubMed : 33833240).
See full target information ATP6V0A1
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

International journal of molecular sciences 24: PubMed37298473

2023

Chondrocyte Thrombomodulin Protects against Osteoarthritis.

Applications

Unspecified application

Species

Unspecified reactive species

Lin Kang,Ai-Lun Yang,Chao-Han Lai,Tsan-Ju Chen,Sung-Yen Lin,Yan-Hsiung Wang,Chau-Zen Wang,Edward M Conway,Hua-Lin Wu,Mei-Ling Ho,Je-Ken Chang,Chung-Hwan Chen,Tsung-Lin Cheng
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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