AB176771

Anti-ATP6V1C2 antibody

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(2 제품이 사용된 논문 )

Rabbit Polyclonal ATP6V1C2 antibody. Suitable for WB, IHC-P and reacts with Human, Mouse samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ATP6V1C2 aa 1 to C-terminus.

대체 명칭 보기

V-type proton ATPase subunit C 2, V-ATPase subunit C 2, Vacuolar proton pump subunit C 2, ATP6V1C2

2 이미지

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ATP6V1C2 antibody (AB176771)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ATP6V1C2 antibody (AB176771)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human fetal heart tissue labeling ATP6V1C2 with ab176771 at 1/100 dilution.

Supplier Data

Western blot - Anti-ATP6V1C2 antibody (AB176771)

All lanes:

Western blot - Anti-ATP6V1C2 antibody (ab176771) at 1/500 dilution

Lane 1:

Human fetal kidney lysate

Lane 2:

Mouse kidney lysate

Predicted band size: 49 kDa

false

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse, Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human ATP6V1C2 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q8NEY4

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/200 - 1/1000", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/200 - 1/1000", "WB-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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특성 및 보관 정보

제형

Lyophilized

Reconstitution

reconstitute with water at 200µL

Purification 테크닉

Affinity purification Immunogen

보관 버퍼

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 1% BSA

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

ATP6V1C2 also known as V-type proton ATPase subunit C 2 is part of the vacuolar ATPase (V-ATPase) complex. This protein performs a mechanical role in transporting hydrogen ions (H+) across cellular membranes which is essential for acidification within various intracellular compartments. The ATP6V1C2 subunit has a molecular mass of approximately 43 kDa. Researchers find that its expression occurs widely throughout the body with notable presence in tissues like the kidney and brain.

Biological function summary

ATP6V1C2 is integral to the V-ATPase complex which participates in maintaining intracellular pH and ion homeostasis. This complex helps in organellar acidification influencing processes such as protein degradation receptor-mediated endocytosis and synaptic vesicle cycling. Among its biological roles ATP6V1C2 ensures the proper function of lysosomal and endosomal pathways promoting cellular metabolism and nutrient processing.

Pathways

ATP6V1C2 has critical roles in biomolecular pathways involved in pH regulation and vesicular trafficking. It is central to pathways like lysosomal acidification and endocytosis. ATP6V1C2 works in conjunction with other V-ATPase subunits such as ATP6V0A4 to facilitate these processes. Through these pathways ATP6V1C2 modulates both macromolecule turnover and neurotransmitter release showcasing its versatile role in cellular metabolism.

ATP6V1C2 links to conditions such as distal renal tubular acidosis and neurodegenerative diseases. Mutations or dysfunction in its associated V-ATPase unit can lead to impaired acidification of urine or defective lysosomal degradation respectively. The protein has interactions with ATP6V0D1 highlighting its involvement in these diseases. By understanding ATP6V1C2’s role researchers can investigate new therapeutic approaches for related disorders.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity (By similarity).

See full target information ATP6V1C2

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제품이 사용된 논문 (2)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Genes 14: PubMed36980869

2023

Distribution and Expression of Pulmonary Ionocyte-Related Factors CFTR, ATP6V0D2, and ATP6V1C2 in the Lungs of Yaks at Different Ages.

Applications

Unspecified application

Species

Unspecified reactive species

Junfeng He,Yating Wei,Yan Cui,Qian Zhang

Nature communications 10:2426 PubMed31160578

2019

The ORC ubiquitin ligase OBI1 promotes DNA replication origin firing.

Applications

Unspecified application

Species

Unspecified reactive species

Philippe Coulombe,Joelle Nassar,Isabelle Peiffer,Slavica Stanojcic,Yvon Sterkers,Axel Delamarre,Stéphane Bocquet,Marcel Méchali

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-ATP6V1C2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ATP6V1C2 antibody (AB176771)

Western blot - Anti-ATP6V1C2 antibody (AB176771)

주요 정보

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Reconstitution

Purification 테크닉

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 기간

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (2)

Product promise