JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB224142

Anti-Atrophin 1 antibody

Be the first to review this product! 리뷰 제출

|

(1 출판물)

Rabbit Polyclonal Atrophin 1 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ATN1 aa 500-700.

대체 명칭 보기

D12S755E, DRPLA, ATN1, Atrophin-1, Dentatorubral-pallidoluysian atrophy protein

2 이미지
Immunocytochemistry/ Immunofluorescence - Anti-Atrophin 1 antibody (AB224142)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-Atrophin 1 antibody (AB224142)

PFA-fixed, Triton X-100 permeabilized U-251 MG (human brain glioma cell line) cells stained for Atrophin 1 (green) using ab224142 at 4 μg/ml in ICC/IF.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Atrophin 1 antibody (AB224142)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Atrophin 1 antibody (AB224142)

Paraffin-embedded human placenta tissue stained for Atrophin 1 using ab224142 at 1/200 dilution in immunohistochemical analysis.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human ATN1 aa 500-700. The exact immunogen used to generate this antibody is proprietary information.

P54259

style
left-column

보완 제품

Primary Antibodies

AB154077

Anti-HEY1 antibody

Immunocytochemistry/ Immunofluorescence - Anti-HEY1 antibody (AB154077)

  • 4
  • 2
Primary Antibodies

AB168372

Anti-Fbx32 antibody [EPR9148(2)]

RabMAb|Recombinant|20ul selling size

Western blot - Anti-Fbx32 antibody [EPR9148(2)] (AB168372)

  • 5
  • 2
Primary Antibodies

AB129002

Anti-Vinculin antibody [EPR8185] - Loading Control

20ul selling size|RabMAb|Recombinant|KO Validated

Immunocytochemistry/ Immunofluorescence - Anti-Vinculin antibody [EPR8185] - Loading Control (AB129002)

  • 5
  • 21
Primary Antibodies

AB254325

Anti-Entactin/NID antibody [EPR22414-125]

BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Entactin/NID antibody [EPR22414-125] (AB254325)

  • 5
  • 1
style
left-column

Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Chimpanzee": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
style
left-column
style
left-column

특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
style
left-column

추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Atrophin 1 also known by names like Atropin is a protein involved in transcriptional regulation. It has a mass of approximately 230 kDa. This protein exhibits wide expression in the body with detectable levels in neuronal tissues and the brain. Atrophin 1 functions to interact with other proteins influencing gene expression through modulation of chromatin structure.
Biological function summary

Atrophin 1 serves essential roles in cellular processes by acting as a transcriptional co-repressor. It participates in developmental functions and neural growth. Atrophin 1 becomes part of protein complexes that alter gene expression by modifying chromatin states. This role connects it with several developmental regulatory networks.

Pathways

Atrophin 1 engages in signaling networks especially those relating to neural development and apoptosis. It interacts within the Notch signaling pathway a significant regulator of cell fate decisions. Atrophin 1 also interfaces with proteins like RBP-Jk facilitating transcriptional output from Notch signaling.

Atrophin 1 is tightly associated with Dentatorubral-pallidoluysian atrophy (DRPLA) a neurodegenerative disorder. In DRPLA Atrophin 1 undergoes polyglutamine expansion resulting in protein misfolding and aggregation. The abnormally expanded Atrophin 1 affects neural integrity. Connections with other proteins like huntingtin which also involves polyglutamine expansions hint at shared disease mechanisms and potential therapeutic targets.
style
left-column
style
left-column

제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

타겟 정보

Transcriptional corepressor. Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation (By similarity). Corepressor of MTG8 transcriptional repression. Has some intrinsic repression activity which is independent of the number of poly-Gln (polyQ) repeats.
See full target information ATN1
style
left-column

제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Experimental and therapeutic medicine 22:1185 PubMed34475975

2021

Detection of mitochondrial coupling factor 6 in placental tissues from preeclamptic pregnancies and its influence on biological behavior of trophoblast cells.

Applications

Unspecified application

Species

Unspecified reactive species

Wanyu Song,Xufeng Shi,Kan Liu,Ranhong Li,Leilei Niu,Lijun Su,Haiying Wu
제품이 사용된 논문 모두 보기
style
left-column
style
left-column
style
right-column

Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com