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AB40798

Anti-b-Myc antibody [EP643Y]

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(2 제품이 사용된 논문 )

Rabbit Recombinant Monoclonal b-Myc antibody. Suitable for WB and reacts with Rat samples. Cited in 2 publications.
1 이미지
Western blot - Anti-b-Myc antibody [EP643Y] (AB40798)
  • WB

Unknown

Western blot - Anti-b-Myc antibody [EP643Y] (AB40798)

All lanes:

Western blot - Anti-b-Myc antibody [EP643Y] (ab40798) at 1/500 dilution

Lane 1:

Rat Brain

Lane 2:

PC12

Predicted band size: 18.3 kDa

Observed band size: 20 kDa

false

관련 conjugated 항체와 다양한 조성의 항체 (1)

  • Carrier free

    Anti-b-Myc antibody [EP643Y] - BSA and Azide free

주요 정보

Host species

Rabbit

Clonality

Monoclonal

Clone number

EP643Y

Isotype

IgG

Carrier free

No

Reacts with

Rat

Applications

WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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보완 제품

Primary Antibodies

AB13834

Anti-HA tag antibody

Lab Essentials

Western blot - Anti-HA tag antibody (AB13834)

  • 5
  • 3
Primary Antibodies

AB128131

HRP Anti-HA tag antibody

Western blot - HRP Anti-HA tag antibody (AB128131)

  • 5
  • 1
Primary Antibodies

AB49763

HRP Anti-DDDDK tag (Binds to FLAG® tag sequence) antibody [M2]

Western blot - HRP Anti-DDDDK tag (Binds to FLAG® tag sequence) antibody [M2] (AB49763)

  • 5
  • 8
Primary Antibodies

AB18230

Anti-DDDDK tag (Binds to FLAG® tag sequence) antibody [F-tag-01]

Lab Essentials

Immunocytochemistry/ Immunofluorescence - Anti-DDDDK tag (Binds to FLAG® tag sequence) antibody [F-tag-01] (AB18230)

  • 4
  • 7
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "<p></p>", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500", "WB-species-notes": "<p></p>" } } }
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제품 세부 정보

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein A
보관 버퍼
pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.05% BSA
배송 시 보관 조건
Conditional Ambient
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

B-Myc also known as B-Myc or MYCL is a member of the Myc family of transcription factors. It is an essential regulator in cellular processes like growth and differentiation. The molecular weight of b-Myc is approximately 24 kDa. This protein acts as a transcriptional repressor and is mainly expressed in tissues such as the mammary gland lung and prostate. It plays a part in suppressing the Myc-mediated gene expression by competing for the same DNA binding sites thereby offering a balance to the functions of other Myc proteins.
Biological function summary

B-Myc functions to modulate transcriptional activities that are necessary for cellular homeostasis. It can associate with other proteins and is often considered part of transcriptional repression complexes. These complexes contribute to regulating gene expression achieving this by directly binding to target DNA sequences or interacting with other transcription factors and co-repressors. Its activities significantly impact cellular differentiation and proliferation providing checks and balances against other members of the Myc family that promote cellular growth.

Pathways

B-Myc is involved in pathways that play a critical role in cell cycle regulation and apoptosis. It actively participates in the Myc signaling pathway where its presence helps counterbalance the more proliferative effects of c-Myc and N-Myc. By doing so it interacts with proteins like Max enabling the formation of different dimers with varying transcriptional roles. Additionally b-Myc's activity within these pathways suggests an intriguing role in modulating cellular responses to growth signals and stressors.

B-Myc's expression and functioning relate to cancer development particularly in breast and prostate cancers. Its capacity to restrain Myc-driven transcriptional programs implies that deviations in b-Myc expression can lead to unregulated cell proliferation and tumorigenesis. In cancerous contexts alterations in b-Myc's interactions with proteins such as EZH2 a component of the PRC2 complex highlight its potential implication in the disruption of normal cellular stability. Understanding b-Myc's role in these diseases offers insights into targeted therapeutic strategies where inhibiting or modulating its function could yield beneficial outcomes.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Seems to act as an inhibitor of cellular proliferation.
See full target information Mycb

대체 명칭 보기

Bmyc, Mycb, Protein B-Myc
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제품이 사용된 논문 (2)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Cell proliferation 55:e13237 PubMed35487760

2022

Increased SPON1 promotes pancreatic ductal adenocarcinoma progression by enhancing IL-6 trans-signalling.

Applications

Unspecified application

Species

Unspecified reactive species

Yanmiao Huo,Jian Yang,Jiahao Zheng,Dapeng Xu,Minwei Yang,Lingye Tao,Hongfei Yao,Xueliang Fu,Jianyu Yang,Dejun Liu,Rong Hua,Junfeng Zhang,Yongwei Sun,Lipeng Hu,Wei Liu

Bioengineered 12:162-171 PubMed33356805

2020

Long non-coding RNA (LncRNA) MRPL23-AS1 promotes tumor progression and carcinogenesis in osteosarcoma by activating Wnt/β-catenin signaling via inhibiting microRNA miR-30b and upregulating myosin heavy chain 9 (MYH9).

Applications

Unspecified application

Species

Unspecified reactive species

Hanwen Zhang,Shuya Liu,Lian Tang,Jianhua Ge,Xiaobo Lu
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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