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AB168120

Anti-B27 antibody

2

(1 리뷰)

|

(1 출판물)

Mouse Polyclonal B27 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human MRAP.

대체 명칭 보기

C21orf61, FALP, MRAP, Melanocortin-2 receptor accessory protein, B27, Fat cell-specific low molecular weight protein, Fat tissue-specific low MW protein

1 이미지
Western blot - Anti-B27 antibody (AB168120)
  • WB

Unknown

Western blot - Anti-B27 antibody (AB168120)

All lanes:

Western blot - Anti-B27 antibody (ab168120) at 1 µg/mL

Lane 1:

B27 transfected 293T cell lysate at 15 µL

Lane 2:

Non-transfected lysate at 15 µL

Secondary

All lanes:

Goat Anti-Mouse IgG

Predicted band size: 19 kDa

false

주요 정보

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human MRAP.

Q8TCY5

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보완 제품

Primary Antibodies

AB225636

Anti-HLA Class 1 ABC antibody [EPR22172]

BOND RX™ Validated|RabMAb|Recombinant|20ul selling size

Immunocytochemistry/ Immunofluorescence - Anti-HLA Class 1 ABC antibody [EPR22172] (AB225636)

  • 4
  • 1
Primary Antibodies

AB9695

Anti-EGF antibody

Sandwich ELISA - Anti-EGF antibody (AB9695)

  • 5
  • 3
Primary Antibodies

AB215889

Anti-beta 2 Microglobulin antibody [B2M/961]

Immunocytochemistry - Anti-beta 2 Microglobulin antibody [B2M/961] (AB215889)

  • 0
  • 0
Primary Antibodies

AB237537

Anti-MRAP2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MRAP2 antibody (AB237537)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>" }, "Chimpanzee": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein A
보관 버퍼
pH: 7.4 Constituents: PBS
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

The B27 protein also known as HLA-B27 is a specific allele of the human leukocyte antigen (HLA) class I molecules. This protein has a mass of approximately 45 kDa and is mainly expressed on the surface of nucleated cells especially in immune cells like lymphocytes. HLA-B27 plays an important role in presenting peptides to the immune system enabling the recognition and clearance of pathogens. This expression helps maintain immune surveillance and promotes the initiation of immune responses.
Biological function summary

This protein assists in the regulation of immune system activities. HLA-B27 does so by forming a complex with beta-2 microglobulin and presenting endogenous antigens to CD8+ T cells. This presentation is important for immune regulation and cellular immunity. The ability of HLA-B27 to bind peptides often shapes immunological responses influencing how the immune system reacts to infectious agents and other antigens.

Pathways

This protein significantly integrates into the antigen processing and presentation pathway. It contributes to the adaptive immune response playing a role in the endosomal/lysosomal pathway where intracellular proteins get degraded into peptides. HLA-B27 works closely with other HLA molecules and the transporter associated with antigen processing (TAP) facilitating efficient peptide loading and transport onto the cell surface.

HLA-B27 shows a strong association with several autoimmune conditions including ankylosing spondylitis and reactive arthritis. Genetic studies suggest that misfolded HLA-B27 may lead to endoplasmic reticulum stress influencing cellular processes related to these conditions. Tumor necrosis factor-alpha (TNF-alpha) often interacts with HLA-B27 within these disease contexts which further highlights the protein's involvement in inflammatory pathways and autoimmune manifestations.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Modulator of melanocortin receptors (MC1R, MC2R, MC3R, MC4R and MC5R). Acts by increasing ligand-sensitivity of melanocortin receptors and enhancing generation of cAMP by the receptors. Required both for MC2R trafficking to the cell surface of adrenal cells and for signaling in response to corticotropin (ACTH). May be involved in the intracellular trafficking pathways in adipocyte cells.
See full target information MRAP
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Journal of molecular endocrinology 56:69-76 PubMed26576642

2015

H295R expression of melanocortin 2 receptor accessory protein results in ACTH responsiveness.

Applications

Unspecified application

Species

Unspecified reactive species

Kazutaka Nanba,Andrew X Chen,Adina F Turcu,William E Rainey
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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