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AB238819

Anti-B3GNT5 antibody

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(2 제품이 사용된 논문 )

Rabbit Polyclonal B3GNT5 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase aa 50-350.

대체 명칭 보기

Lactotriaosylceramide synthase, Lc(3)Cer synthase, Lc3 synthase, BGnT-5, Beta3Gn-T5, B3GNT5

2 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-B3GNT5 antibody (AB238819)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-B3GNT5 antibody (AB238819)

Paraffin-embedded human testis tissue stained for B3GNT5 using ab238819 at 1/100 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-B3GNT5 antibody (AB238819)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-B3GNT5 antibody (AB238819)

Paraffin-embedded human lung tissue stained for B3GNT5 using ab238819 at 1/100 dilution in immunohistochemical analysis.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase aa 50-350. The exact immunogen used to generate this antibody is proprietary information.

Q9BYG0

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보완 제품

Primary Antibodies

AB176689

Anti-ZNF384 antibody

Immunoprecipitation - Anti-ZNF384 antibody (AB176689)

  • 5
  • 1
Primary Antibodies

AB32445

Anti-Bad antibody [Y208]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Bad antibody [Y208] (AB32445)

  • 4
  • 13
Primary Antibodies

AB185645

Anti-Caspase-6/CASP-6 antibody [EPR18043]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-Caspase-6/CASP-6 antibody [EPR18043] (AB185645)

  • 0
  • 1
Primary Antibodies

AB180522

Anti-EDEM2 antibody [EPR14043-24]

RabMAb|Recombinant

Western blot - Anti-EDEM2 antibody [EPR14043-24] (AB180522)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein G
Purification 관련 사항
Purity greater than 95%.
보관 버퍼
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

B3GNT5 also known as UDP-GlcNAc:betaGal beta-13-N-acetylglucosaminyltransferase 5 functions primarily as a glycosyltransferase enzyme. It has a molecular mass of approximately 42 kDa. B3GNT5 is expressed in various tissues including the brain and muscle and is critical for synthesizing poly-N-acetyllactosamine which is important for cellular communication and adhesion processes.
Biological function summary

The B3GNT5 enzyme facilitates the addition of N-acetylglucosamine in a beta-13 linkage to galactose residues on glycoconjugates. It contributes significantly to glycan biosynthesis and may participate in forming part of glycoprotein and glycolipid complexes. These glycoconjugates impact cell signaling migration and cell-cell interactions. The precise formation of glycoconjugates supports critical cellular functions influencing processes like immune response and cellular differentiation.

Pathways

B3GNT5 plays a role in the complex glycosylation pathway. This pathway involves the assembly and modification of glycan structures essential for protein stability and function. B3GNT5 interacts with other enzymes such as B3GNT2 impacting the regulation of glycan chains. The pathway affects key processes like the production of selectin ligands which are vital for leukocyte trafficking and inflammatory responses.

Abnormalities in B3GNT5 expression or function can link to cancer progression and congenital disorders of glycosylation. Changes in its activity influence the expression and remodeling of glycans potentially affecting tumor cell interaction and metastasis. In some congenital glycosylation disorders defective glycan synthesis might relate to developmental issues where B3GNT5 and its glycan partner proteins play a role in ensuring proper cellular development and function.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Beta-1,3-N-acetylglucosaminyltransferase that plays a key role in the synthesis of lacto- or neolacto-series carbohydrate chains on glycolipids, notably by participating in biosynthesis of HNK-1 and Lewis X carbohydrate structures. Has strong activity toward lactosylceramide (LacCer) and neolactotetraosylceramide (nLc(4)Cer; paragloboside), resulting in the synthesis of Lc(3)Cer and neolactopentaosylceramide (nLc(5)Cer), respectively. Probably plays a central role in regulating neolacto-series glycolipid synthesis during embryonic development.
See full target information Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase
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제품이 사용된 논문 (2)

Recent publications for all applications. Explore the 전체 목록 and refine your search

EBioMedicine 66:103301 PubMed33813137

2021

A circular network of coregulated sphingolipids dictates lung cancer growth and progression.

Applications

Unspecified application

Species

Unspecified reactive species

Qiong Meng,Xueting Hu,Xinbao Zhao,Xiangzhan Kong,Ya-Ming Meng,Yitian Chen,Liangping Su,Xue Jiang,Xiaoyi Qiu,Cheng Huang,Chao Liu,Minghui Wang,Ping-Pui Wong

Cell reports. Medicine 2:100166 PubMed33521697

2021

A distinct innate immune signature marks progression from mild to severe COVID-19.

Applications

Unspecified application

Species

Unspecified reactive species

Stéphane Chevrier,Yves Zurbuchen,Carlo Cervia,Sarah Adamo,Miro E Raeber,Natalie de Souza,Sujana Sivapatham,Andrea Jacobs,Esther Bachli,Alain Rudiger,Melina Stüssi-Helbling,Lars C Huber,Dominik J Schaer,Jakob Nilsson,Onur Boyman,Bernd Bodenmiller
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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