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AB110398

Anti-B4GALT5 antibody

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(4 제품이 사용된 논문 )

Rabbit Polyclonal B4GALT5 antibody. Suitable for WB and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human B4GALT5.

대체 명칭 보기

Beta4Gal-T5, b4Gal-T5, Lactosylceramide synthase, LacCer synthase, B4GALT5

1 이미지
Western blot - Anti-B4GALT5 antibody (AB110398)
  • WB

Unknown

Western blot - Anti-B4GALT5 antibody (AB110398)

All lanes:

Western blot - Anti-B4GALT5 antibody (ab110398) at 1/500 dilution

Lane 1:

Extracts from HeLa cells at 30 µg

Lane 2:

Extracts from 293 cells at 30 µg

Lane 3:

Extracts from Huvec cells at 30 µg

Lane 4:

Extracts from HuvEc cells at 30 µg with immunising peptide

Predicted band size: 45 kDa

false

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human B4GALT5. The exact immunogen used to generate this antibody is proprietary information.

O43286

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대체품

Primary Antibodies

AB155905

Anti-B4GALT5 antibody

Western blot - Anti-B4GALT5 antibody (AB155905)

  • 0
  • 0

보완 제품

Primary Antibodies

AB124296

Anti-Ceramide glucosyltransferase antibody

Western blot - Anti-Ceramide glucosyltransferase antibody (AB124296)

  • 0
  • 0
Primary Antibodies

AB121326

Anti-B4GALT1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-B4GALT1 antibody (AB121326)

  • 5
  • 2
Primary Antibodies

AB87977

Anti-MGAT5 antibody [3E9]

Flow Cytometry - Anti-MGAT5 antibody [3E9] (AB87977)

  • 4
  • 5
Primary Antibodies

AB183033

Anti-Scc4 antibody [EPR14390]

20ul selling size|RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-Scc4 antibody [EPR14390] (AB183033)

  • 5
  • 1
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
보관 정보
Stable for 12 months at -20°C
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

B4GALT5 also known as beta-14-galactosyltransferase 5 is an enzyme critical for glycosylation processes. This enzyme has a molecular weight of approximately 43 kDa. It adds galactose to specific carbohydrate structures and plays a role in forming lactose and other glycan structures. This enzyme is part of the larger beta-14-galactosyltransferase family and is found in the Golgi apparatus. It is expressed in various tissues with significant activity in the liver and kidney and to a certain extent in the brain.
Biological function summary

B4GALT5 is involved in the synthesis of complex glycoconjugates and lactose. It contributes to the N-linked and O-linked glycosylation of proteins which are essential for protein folding stability and cell signaling. B4GALT5 forms part of the enzyme complex responsible for elongating glycan chains cooperating with other glycosyltransferases. Through its enzymatic activity it affects cell-cell interactions host-pathogen recognition and immune responses.

Pathways

B4GALT5 is an important component of the glycan biosynthesis and metabolism pathways. Its action affects the glycoprotein quality control and folding pathways. In these processes it works alongside other glycosyltransferases such as B4GALT1 ensuring proper glycoconjugate formation and modification. These pathways influence developmental processes immune system functions and normal cellular operations.

B4GALT5 has links to congenital disorders of glycosylation and cancer. Abnormal glycosylation can alter cell adhesion and migration contributing to tumorigenesis and metastasis. The enzyme shows altered expression levels in certain cancers suggesting its role as a potential biomarker. B4GALT5 has associations with other proteins like E-cadherin where changes in glycosylation patterns can influence cancer progression and immune evasion.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Catalyzes the synthesis of lactosylceramide (LacCer) via the transfer of galactose from UDP-galactose to glucosylceramide (GlcCer) (PubMed : 24498430). LacCer is the starting point in the biosynthesis of all gangliosides (membrane-bound glycosphingolipids) which play pivotal roles in the CNS including neuronal maturation and axonal and myelin formation (By similarity). Plays a role in the glycosylation of BMPR1A and regulation of its protein stability (By similarity). Essential for extraembryonic development during early embryogenesis (By similarity).
See full target information B4GALT5
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제품이 사용된 논문 (4)

Recent publications for all applications. Explore the 전체 목록 and refine your search

British journal of cancer 128:2116-2125 PubMed37016102

2023

Development of the semi-dry dot-blot method for intraoperative detecting micropapillary component in lung adenocarcinoma based on proteomics analysis.

Applications

Unspecified application

Species

Unspecified reactive species

Long Xu,Hang Su,Shengnan Zhao,Haojie Si,Huikang Xie,Yijiu Ren,Jiani Gao,Fang Wang,Xiaofeng Xie,Chenyang Dai,Chunyan Wu,Deping Zhao,Chang Chen

Journal of ovarian research 16:5 PubMed36611197

2023

A signature based on glycosyltransferase genes provides a promising tool for the prediction of prognosis and immunotherapy responsiveness in ovarian cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Xuyao Xu,Yue Wu,Genmei Jia,Qiaoying Zhu,Dake Li,Kaipeng Xie

International journal of laboratory hematology 44:320-332 PubMed34709725

2021

Circ_0009910 sponges miR-491-5p to promote acute myeloid leukemia progression through modulating B4GALT5 expression and PI3K/AKT signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Yingwei Wu,Bo Zhao,Xianghua Chen,Xueli Geng,Zhihua Zhang

Neuromolecular medicine 21:33-41 PubMed30607818

2019

Hsc70 Interacts with β4GalT5 to Regulate the Growth of Gliomas.

Applications

Unspecified application

Species

Unspecified reactive species

Guan Sun,Ying Cao,Xueliang Dai,Min Li,Jun Guo
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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