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AB168389

Anti-BAFF-R antibody [EPR10914]

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(2 제품이 사용된 논문 )

Rabbit Recombinant Monoclonal BAFF-R antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications.

대체 명칭 보기

CD268, BAFFR, BR3, TNFRSF13C, Tumor necrosis factor receptor superfamily member 13C, B-cell-activating factor receptor, BAFF receptor, BLyS receptor 3, BAFF-R

3 이미지
Immunocytochemistry/ Immunofluorescence - Anti-BAFF-R antibody [EPR10914] (AB168389)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-BAFF-R antibody [EPR10914] (AB168389)

Immunofluorescent analysis of Raji cells labeling BAFF-R with ab168389 at 1/50 dilution.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-BAFF-R antibody [EPR10914] (AB168389)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-BAFF-R antibody [EPR10914] (AB168389)

Immunohistochemical analysis of paraffin-embedded Human colon tissue labeling BAFF-R with ab168389 at 1/250 dilution.

Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-BAFF-R antibody [EPR10914] (AB168389)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-BAFF-R antibody [EPR10914] (AB168389)

Immunohistochemical analysis of paraffin-embedded Human tonsil tissue labeling BAFF-R with ab168389 at 1/250 dilution.

Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

관련 conjugated 항체와 다양한 조성의 항체 (1)

  • Carrier free

    Anti-BAFF-R antibody [EPR10914] - BSA and Azide free

주요 정보

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR10914

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, IHC-P

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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대체품

Primary Antibodies

AB233775

Anti-BAFF-R antibody [5A9B6]

Flow Cytometry - Anti-BAFF-R antibody [5A9B6] (AB233775)

  • 0
  • 0
Primary Antibodies

AB188868

Anti-BAFF-R antibody [EPR14633]

20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-BAFF-R antibody [EPR14633] (AB188868)

  • 0
  • 0
Primary Antibodies

AB16582

Biotin Anti-BAFF-R antibody [11C1]

  • 0
  • 0
Primary Antibodies

AB5965

Anti-BAFF-R antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-BAFF-R antibody (AB5965)

  • 0
  • 0

보완 제품

Assay Kits

AB213839

Human BAFF-R ELISA Kit

Sandwich ELISA - Human BAFF-R ELISA Kit (AB213839)

  • 0
  • 0
Primary Antibodies

AB5972

Anti-BCMA antibody - C-terminal

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-BCMA antibody - C-terminal (AB5972)

  • 0
  • 0
Primary Antibodies

AB245833

Anti-BAFF antibody [EPR22238] - BSA and Azide free

RabMAb|Recombinant

Flow Cytometry - Anti-BAFF antibody [EPR22238] - BSA and Azide free (AB245833)

  • 0
  • 0
Primary Antibodies

AB128936

Anti-Syndecan-1 antibody [EPR6454]

20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Syndecan-1 antibody [EPR6454] (AB128936)

  • 5
  • 7
Primary Antibodies

AB134114

Anti-CD19 antibody [EPR5906]

BOND RX™ Validated|RabMAb|Recombinant|Lab Essentials|20ul selling size

Flow Cytometry (Intracellular) - Anti-CD19 antibody [EPR5906] (AB134114)

  • 4
  • 5
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/250 - 1/500", "IHCP-species-notes": "<p></p>", "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "<p></p>", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p></p>", "WB-species-checked": "notRecommended", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/100", "ICCIF-species-notes": "<p></p>" } } }
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제품 세부 정보

Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
Please contact us for more information.

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein A
보관 버퍼
pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
배송 시 보관 조건
Conditional Ambient
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

BAFF-R also known as B-cell activating factor receptor or BAFF receptor plays a critical role in B-cell development and survival. BAFF-R is a receptor for the BAFF protein also referred to as B lymphocyte stimulator (BLyS). BAFF-R has a molecular mass of approximately 19 kDa. The expression of BAFF-R is found on B cells with higher presence on mature B cells compared to immature ones. The receptor is recognized as the main signaling partner for BAFF which forms the basis for many of its immune functions.
Biological function summary

BAFF-R is essential for the maturation and maintenance of peripheral B cells. The receptor contributes to the regulation of immune responses by ensuring B-cell homeostasis. It does not generally form part of a larger protein complex but instead functions as a membrane-bound receptor that transmits signals upon binding with the BAFF ligand. This signaling cascade supports the survival and proliferation of B cells which is fundamental for the adaptive immune system.

Pathways

BAFF-R is deeply involved in the NF-κB signaling pathway which is important for immune regulation and cell survival. Upon binding with BAFF BAFF-R recruits associated proteins to initiate the pathway and as a result promotes gene transcription important for B-cell function. Another connected pathway involves AKT a protein kinase that regulates B-cell metabolism and differentiation. Both NF-κB and AKT pathways help facilitate the immune functions tied to B cells directly through BAFF-R signaling.

BAFF-R demonstrates a notable link with autoimmune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis. Overexpression of BAFF impacting interaction with BAFF-R contributes to such conditions by promoting the survival of autoreactive B cells. In SLE BAFF works with another receptor TACI influencing the proliferation of autoreactive cells. The persistent activation and dysfunction of the immune response through BAFF-R interactions exacerbate these autoimmune conditions.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response.
See full target information TNFRSF13C
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제품이 사용된 논문 (2)

Recent publications for all applications. Explore the 전체 목록 and refine your search

European journal of endocrinology 192:191-201 PubMed39960854

2025

Discordance between adrenal vein sampling and imaging: the role of unilateral cortisol excess.

Applications

Unspecified application

Species

Unspecified reactive species

Megan Grundy,Alexander A Leung,Martin Hyrcza,Janice L Pasieka,Denise Chan,Stefan J Przybojewski,Chi-Bun Benny So,Dennis Orton,Adrian Harvey,Gregory A Kline

Frontiers in immunology 14:1166497 PubMed37234171

2023

Tertiary lymphoid structures predict the prognosis and immunotherapy response of cholangiocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Taiyu Shang,Tianyi Jiang,Tao Lu,Hui Wang,Xiaowen Cui,Yufei Pan,Mengyou Xu,Mengmiao Pei,Zhiwen Ding,Xiaofan Feng,Yunkai Lin,Xin Li,Yexiong Tan,Feiling Feng,Hui Dong,Hongyang Wang,Liwei Dong
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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