AB10505

Anti-BDNF antibody [35928.11]

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(1 리뷰)

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(15 제품이 사용된 논문 )

Mouse Monoclonal BDNF antibody. Suitable for ELISA, WB, IHC-P and reacts with Human samples. Cited in 15 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human BDNF.

대체 명칭 보기

Neurotrophic factor BDNF precursor form, proBDNF, Abrineurin, Brain-derived neurotrophic factor, BDNF

주요 정보

Host species

Mouse

Clonality

Monoclonal

Clone number

35928.11

Isotype

IgG1

Carrier free

No

Reacts with

Human

Applications

ELISA, WB, IHC-P

Immunogen

Recombinant Full Length Protein corresponding to Human BDNF.

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대체품

Primary Antibodies

AB213323

Anti-BDNF antibody [EPR21211]

20ul selling size|BOND RX™ Validated|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-BDNF antibody [EPR21211] (AB213323)

0
0

Primary Antibodies

AB222321

Alexa Fluor® 647 Anti-BDNF antibody [EPR1292]

BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Alexa Fluor® 647 Anti-BDNF antibody [EPR1292] (AB222321)

0
0

Primary Antibodies

AB108319

Anti-BDNF antibody [EPR1292]

BOND RX™ Validated|RabMAb|Recombinant|20ul selling size

Western blot - Anti-BDNF antibody [EPR1292] (AB108319)

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10

Primary Antibodies

AB216443

Anti-BDNF antibody [EPR1292] - Low endotoxin, Azide free

RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-BDNF antibody [EPR1292] - Low endotoxin, Azide free (AB216443)

0
0

Primary Antibodies

AB205067

Anti-BDNF antibody [3B2]

Immunocytochemistry/ Immunofluorescence - Anti-BDNF antibody [3B2] (AB205067)

0
0

Primary Antibodies

AB222113

Alexa Fluor® 488 Anti-BDNF antibody [EPR1292]

BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Alexa Fluor® 488 Anti-BDNF antibody [EPR1292] (AB222113)

0
0

보완 제품

Primary Antibodies

AB177487

Anti-NeuN antibody [EPR12763] - Neuronal Marker

BOND RX™ Validated|RabMAb|Recombinant|Lab Essentials|20ul selling size|Advanced Validation

Immunohistochemistry (Frozen sections) - Anti-NeuN antibody [EPR12763] - Neuronal Marker (AB177487)

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74

Primary Antibodies

AB32096

Anti-CREB (phospho S133) antibody [E113]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-CREB (phospho S133) antibody [E113] (AB32096)

4
14

Primary Antibodies

AB178846

Anti-Iba1 antibody [EPR16588] - Microglia marker

20ul selling size|BOND RX™ Validated|RabMAb|Recombinant|Lab Essentials

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Iba1 antibody [EPR16588] - Microglia marker (AB178846)

5
50

Primary Antibodies

AB278054

Anti-GFAP antibody [RM1003] - Astrocyte Marker

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GFAP antibody [RM1003] - Astrocyte Marker (AB278054)

0
0

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" } } }

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제품 세부 정보

Endotoxin: <10 ng/mg by LAL method. For BDNF, multiple WB bands are possible and expected. The human protein has 5 isoforms (precursors: 28 – 37 kDa) and can be glycosylated (Uniprot: http://www.uniprot.org/uniprot/P23560). The mature form is expected at ~14 kDa (monomer) and the dimer at ~28 kDa.

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Protein A

Purification 관련 사항

The antibody is purified by Protein A affinity chromatography.

보관 버퍼

Constituents: PBS

배송 시 보관 조건

Blue Ice

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Important signaling molecule that activates signaling cascades downstream of NTRK2 (PubMed : 11152678). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.. Neurotrophic factor BDNF precursor form. Important signaling molecule that activates signaling cascades downstream of NTRK2. Activates signaling cascades via the heterodimeric receptor formed by NGFR and SORCS2 (PubMed : 24908487, PubMed : 29909994). Signaling via NGFR and SORCS2 plays a role in synaptic plasticity and long-term depression (LTD). Binding to NGFR and SORCS2 promotes neuronal apoptosis. Promotes neuronal growth cone collapse (By similarity).

See full target information BDNF

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제품이 사용된 논문 (15)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Frontiers in cellular neuroscience 16:812887 PubMed35418836

2022

Metabolic Reprogramming in HIV-Associated Neurocognitive Disorders.

Applications

Unspecified application

Species

Unspecified reactive species

Charles N S Allen,Sterling P Arjona,Maryline Santerre,Claudio De Lucia,Walter J Koch,Bassel E Sawaya

Frontiers in medicine 7:353 PubMed32793611

2020

LncRNA Rik-203 Contributes to Sevoflurane Induced Neurotoxicity?

Applications

Unspecified application

Species

Unspecified reactive species

Lei Zhang,Zhenyu Xue,Jia Yan,Hong Jiang

Aging 12:11446-11465 PubMed32544883

2020

microRNA-9 and -29a regulate the progression of diabetic peripheral neuropathy ISL1-mediated sonic hedgehog signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Qin Sun,Jun Zeng,Yang Liu,JingYan Chen,Qing-Cui Zeng,Yan-Qiu Chen,Li-Li Tu,Ping Chen,Fan Yang,Min Zhang

Journal of oral rehabilitation 47:843-850 PubMed32277715

2020

Daytime changes of salivary biomarkers involved in pain.

Applications

Unspecified application

Species

Unspecified reactive species

Hajer Jasim,Bijar Ghafouri,Anders Carlsson,Britt Hedenberg-Magnusson,Malin Ernberg

Brain and behavior 8:e01127 PubMed30298999

2018

Total saponins from the leaves of Panax notoginseng inhibit depression on mouse chronic unpredictable mild stress model by regulating circRNA expression.

Applications

Unspecified application

Species

Unspecified reactive species

Hualin Zhang,Ziming Chen,Zhiyong Zhong,Weifan Gong,Jun Li

The American journal of pathology 188:2281-2292 PubMed30031725

2018

IL-1β Stimulates Brain-Derived Neurotrophic Factor Production in Eutopic Endometriosis Stromal Cell Cultures: A Model for Cytokine Regulation of Neuroangiogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Jie Yu,Antônio M C Francisco,Bansari G Patel,J Mark Cline,Eric Zou,Sarah L Berga,Robert N Taylor

Scientific reports 8:3220 PubMed29459715

2018

Saliva as a medium to detect and measure biomarkers related to pain.

Applications

Unspecified application

Species

Unspecified reactive species

Hajer Jasim,Anders Carlsson,Britt Hedenberg-Magnusson,Bijar Ghafouri,Malin Ernberg

Molecular medicine reports 17:4083-4089 PubMed29257320

2017

MicroRNA-103 suppresses glioma cell proliferation and invasion by targeting the brain-derived neurotrophic factor.

Applications

Unspecified application

Species

Unspecified reactive species

Ling Wang,Ying Liu,Jianwei Song

Journal of cellular biochemistry 118:3875-3882 PubMed28390174

2017

Suppression of Basic Fibroblast Growth Factor Expression by Antisense Oligonucleotides Inhibits Neural Stem Cell Proliferation and Differentiation in Rat models With Focal Cerebral Infarction.

Applications

Unspecified application

Species

Unspecified reactive species

Chao Li,Li-He Che,Lei Shi,Jin-Lu Yu

Scientific reports 6:28599 PubMed27345430

2016

Focused ultrasound-enhanced intranasal brain delivery of brain-derived neurotrophic factor.

Applications

Unspecified application

Species

Unspecified reactive species

Hong Chen,Georgiana Zong Xin Yang,Hoheteberhan Getachew,Camilo Acosta,Carlos Sierra Sánchez,Elisa E Konofagou

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

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