AB54790

Anti-Beta Arrestin 2 antibody [3G1]

Name: Anti-Beta Arrestin 2 antibody [3G1]
Brand: Abcam Limited
SKU: AB54790
Rating: 5 (3 reviews)

KO Validated
각 태그의 뜻

(3 리뷰들)

(32 제품이 사용된 논문 )

Mouse Monoclonal Beta Arrestin 2 antibody. Carrier free. Suitable for Flow Cyt, WB, IHC-P, ICC/IF and reacts with Human, Mouse, Transfected cell lysate - Human samples. Cited in 32 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ARRB2 aa 300 to C-terminus.

9 이미지

Flow Cytometry - Anti-Beta Arrestin 2 antibody [3G1] (AB54790)

Flow Cyt

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Flow Cytometry - Anti-Beta Arrestin 2 antibody [3G1] (AB54790)

Overlay histogram showing HeLa cells stained with ab54790 (red line). The cells were fixed with 4% paraformaldehyde (10 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab54790, 1μg/1x10⁶ cells) for 30 min at 22°C. The secondary antibody used was DyLight® 488 goat anti-mouse IgG (H+L) (ab96879) at 1/500 dilution for 30 min at 22°C. Isotype control antibody (black line) was a mix of mouse IgG2a [ICIGG2A], (ab91361, 1μg/1x10⁶ cells) used under the same conditions. Acquisition of >5,000 events was performed. This antibody gave a positive signal in HeLa cells fixed with 80% methanol/permeabilized in 0.1% PBS-Tween used under the same conditions.

This image was generated using the ascites version of the product.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Beta Arrestin 2 antibody [3G1] (AB54790)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Beta Arrestin 2 antibody [3G1] (AB54790)

Beta Arrestin 2 antibody (ab54790) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human tonsil.

This image was generated using the ascites version of the product.

Immunocytochemistry/ Immunofluorescence - Anti-Beta Arrestin 2 antibody [3G1] (AB54790)

ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-Beta Arrestin 2 antibody [3G1] (AB54790)

ab54790 at 10 ug/ml staining Beta Arrestin 2 in human Hela cells by Immunocytochemistry / Immunofluorescence.

This image was generated using the ascites version of the product.

Lab

Western blot - Anti-Beta Arrestin 2 antibody [3G1] (AB54790)

Western blot : Anti-ARRB2 antibody [3G1] (ab54790) staining at 1 ug/ml, shown in green; Rabbit Anti-GAPDH antibody [EPR16891] (ab181602) loading control staining at 1/20000 dilution, shown in magenta. In Western blot, ab54790 was shown to bind specifically to ARRB2. A band was observed at 45 kDa in wild-type A549 cell lysates with no signal observed at this size in ARRB2 knockout cell line. To generate this image, wild-type and ARRB2 knockout A549 cell lysates were analysed. First, samples were run on an SDS-PAGE gel then transferred onto a nitrocellulose membrane. Membranes were blocked in fluorescent western blot (TBS-based) blocking solution before incubation with primary antibodies overnight at 4 °C. Blots were washed four times in TBS-T, incubated with secondary antibodies for 1 h at room temperature, washed again four times then imaged. Secondary antibodies used were Goat anti-Mouse IgG H&L 800CW and Goat anti-Rabbit IgG H&L 680RD at 1/20000 dilution.

All lanes:

Western blot - Anti-Beta Arrestin 2 antibody [3G1] (ab54790) at 1 µg/mL

Lane 1:

Wild-type A549 cell lysate at 20 µg

Lane 2:

ARRB2 knockout A549 cell lysate at 20 µg

Lane 2:

Western blot - Human ARRB2 (Beta Arrestin 2) knockout A549 cell line (<a href='/ko/products/cell-lines/human-arrb2-beta-arrestin-2-knockout-a549-cell-line-ab277840'>ab277840</a>)

Lane 3:

Wild-type HepG2 <a href='/ko/products/cell-lines/human-arrb2-beta-arrestin-2-knockout-hep-g2-cell-line-ab262320'>ab262320</a> cell lysate at 20 µg

Lane 4:

ARRB2 knockout HepG2 <a href='/ko/products/cell-lines/human-arrb2-beta-arrestin-2-knockout-hep-g2-cell-line-ab262320'>ab262320</a> cell lysate at 20 µg

Secondary

All lanes:

Goat anti-Mouse IgG H&L 800CW and Goat anti-Rabbit IgG H&L 680RD at 1/20000 dilution

Observed band size: 45 kDa

false

Lab

Western blot - Anti-Beta Arrestin 2 antibody [3G1] (AB54790)

Lanes 1 - 4 : Merged signal (red and green). Green - ab54790 observed at 50 kDa. Red - loading control ab181602 (Rabbit Anti-GAPDH antibody [EPR16891]) observed at 37 kDa.

ab54790 was shown to react with Beta Arrestin 2 in wild-type HepG2 cells in Western blot with loss of signal observed in ARRB2 knockout cell line ab262320 (knockout cell lysate ab257283). Wild-type HepG2 and ARRB2 knockout cell lysates were subjected to SDS-PAGE. Membranes were blocked in fluorescent western blot (TBS-based) blocking solution before incubation with ab54790 and ab181602 (Rabbit Anti-GAPDH antibody [EPR16891]) overnight at 4 °C at 1 μg/ml and a 1 in 20000 dilution respectively. Blots were incubated with Goat anti-Mouse IgG H&L (IRDye^® 800CW) preabsorbed (ab216772) and Goat anti-Rabbit IgG H&L (IRDye^® 680RD) preabsorbed (ab216777) secondary antibodies at 1 in 20000 dilution for 1 h at room temperature before imaging.

All lanes:

Western blot - Anti-Beta Arrestin 2 antibody [3G1] (ab54790) at 1 µg/mL

Lane 1:

Wild-type HepG2 cell lysate at 20 µg

Lane 2:

ARRB2 knockout HepG2 cell lysate at 20 µg

Lane 2:

Western blot - Human ARRB2 (Beta Arrestin 2) knockout Hep G2 cell line (<a href='/ko/products/cell-lines/human-arrb2-beta-arrestin-2-knockout-hep-g2-cell-line-ab262320'>ab262320</a>)

Lane 3:

HeLa cell lysate at 20 µg

Lane 4:

Human Lung tissue lysate at 20 µg

Predicted band size: 46 kDa

Observed band size: 50 kDa

false

Lab

Western blot - Anti-Beta Arrestin 2 antibody [3G1] (AB54790)

Lanes 1- 4 : Merged signal (red and green). Green - ab54790 observed at 55 kDa. Red - Anti-GAPDH antibody[EPR16891] - Loading Control (ab181602) observed at 37 kDa.

ab54790 was shown to react with ARRB2 in wild-type HepG2 cells in western blot. Loss of signal was observed when knockout cell line ab262320 (knockout cell lysate ab257283) was used. Wild-type HepG2 and ARRB2 knockout HepG2 cell lysates were subjected to SDS-PAGE. Membrane was blocked for 1 hour at room temperature in 0.1% TBST with 3% non-fat dried milk. ab54790 and Anti-GAPDH antibody[EPR16891] - Loading Control (ab181602) overnight at 4°C at a 1 in 500 dilution and a 1 in 20000 dilution respectively. Blots were developed with Goat anti-Mouse IgG H&L (IRDye^®800CW) preadsorbed (ab216772) and Goat Anti-Rabbit IgG H&L (IRDye^®680RD) preadsorbed (ab216777) secondary antibodies at 1 in 20000 dilution for 1 hour at room temperature before imaging.

All lanes:

Western blot - Anti-Beta Arrestin 2 antibody [3G1] (ab54790) at 1/500 dilution

Lane 1:

Wild-type HepG2 cell lysate at 20 µg

Lane 2:

ARRB2 knockout HepG2 cell lysate at 20 µg

Lane 2:

Western blot - Human ARRB2 (Beta Arrestin 2) knockout Hep G2 cell line (<a href='/ko/products/cell-lines/human-arrb2-beta-arrestin-2-knockout-hep-g2-cell-line-ab262320'>ab262320</a>)

Lane 3:

A549 cell lysate at 20 µg

Lane 4:

K562 cell lysate at 20 µg

Predicted band size: 46 kDa

Observed band size: 55 kDa

false

Unknown

Western blot - Anti-Beta Arrestin 2 antibody [3G1] (AB54790)

Lanes 1-4 : Merged signal (red and green). Green - ab54790 observed at 48-55 kDa. Red - loading control, ab181602 observed at 37 kDa.

ab54790 Anti-Beta Arrestin 2 antibody was shown to specifically react with Beta Arrestin 2 in wild-type HEK293T cells. Loss of signal was observed when knockout cell line ab266116 (knockout cell lysate ab257282) was used. Wild-type and Beta Arrestin 2 knockout samples were subjected to SDS-PAGE. ab54790 and Anti-GAPDH antibody [EPR16891] - Loading Control (ab181602) were incubated overnight at 4°C at 1 in 500 dilution and 1 in 20000 dilution respectively. Blots were developed with Goat anti-Mouse IgG H&L (IRDye^® 800CW) preadsorbed (ab216772) and Goat anti-Rabbit IgG H&L (IRDye^® 680RD) preadsorbed (ab216777) secondary antibodies at 1 in 10000 dilution for 1 hour at room temperature before imaging.

All lanes:

Western blot - Anti-Beta Arrestin 2 antibody [3G1] (ab54790) at 1/500 dilution

Lane 1:

Wild-type HEK293T cell lysate at 20 µg

Lane 2:

ARRB2 knockout HEK293T cell lysate at 20 µg

Lane 3:

Mouse brain tissue lysate at 20 µg

Lane 4:

Human lung tissue lysate at 20 µg

Predicted band size: 46 kDa

Observed band size: 48-55 kDa

false

Lab

Western blot - Anti-Beta Arrestin 2 antibody [3G1] (AB54790)

Lanes 1-4 : Merged signal (red and green). Green - ab54790 observed at 48-55 kDa. Red - loading control, ab181602 observed at 37 kDa.

All lanes:

Western blot - Anti-Beta Arrestin 2 antibody [3G1] (ab54790) at 1/500 dilution

Lane 1:

Wild-type HEK293T cell lysate at 20 µg

Lane 2:

ARRB2 knockout HEK293T cell lysate at 20 µg

Lane 2:

Western blot - Human ARRB2 (Beta Arrestin 2) knockout HEK-293T cell line (<a href='/ko/products/cell-lines/human-arrb2-beta-arrestin-2-knockout-hek-293t-cell-line-ab266116'>ab266116</a>)

Lane 3:

Mouse brain tissue lysate at 20 µg

Lane 4:

Human lung tissue lysate at 20 µg

Predicted band size: 46 kDa

Observed band size: 55 kDa

false

Unknown

Western blot - Anti-Beta Arrestin 2 antibody [3G1] (AB54790)

Western blot against tagged recombinant protein immunogen using ab54790 Beta Arrestin 2 antibody at 1ug/ml. Predicted band size of immunogen is 35 kDa

This image was generated using the ascites version of the product.

All lanes:

Western blot - Anti-Beta Arrestin 2 antibody [3G1] (ab54790)

Predicted band size: 46 kDa

false

주요 정보

Host species

Mouse

Clonality

Monoclonal

Clone number

3G1

Isotype

IgG2a

Light chain 타입

kappa

Carrier free

Yes

Reacts with

Mouse, Human

Applications

Flow Cyt, IHC-P, ICC/IF, WB

applications

Immunogen

Recombinant Fragment Protein within Human ARRB2 aa 300 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

P32121

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<a href='/ko/products/primary-antibodies/mouse-igg2c-kappa-monoclonal-18c8bc7ad10-isotype-control-ab170191'>ab170191</a> - Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Mouse": { "FlowCyt-species-checked": "guaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Transfected cell lysate - Human": { "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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제품 세부 정보

This product was changed from ascites to tissue culture supernatant on 13^th Feb 2019. Please note that the dilutions may need to be adjusted accordingly. If you have any questions, please do not hesitate to contact our scientific support team.

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Protein A

보관 버퍼

pH: 7.4 Constituents: PBS

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Beta-arrestin 2 also known as arrb2 or b-arrestin mechanically functions to regulate G protein-coupled receptor (GPCR) signaling. This protein has a molecular mass of approximately 47 kDa and is ubiquitously expressed across various tissues including the brain lungs and heart. Beta-arrestin 2 works by binding to phosphorylated GPCRs facilitating receptor desensitization and endocytosis which stops the receptor's signaling activity and mediates receptor internalization.

Biological function summary

Beta-arrestin 2 plays an important role in mediating signal transduction pathways beyond GPCR desensitization including those involved in cell communication and cellular response regulation. Beta-arrestin 2 interacts with multiple signaling proteins to form complexes that facilitate signaling pathways notably influencing MAPK (Mitogen-Activated Protein Kinase) pathways. It provides a scaffold for downstream signaling molecules affecting cell signaling outcomes.

Pathways

Beta-arrestin 2 significantly participates in two important biological pathways: the MAPK pathway and the Wnt signaling pathway. Through these pathways beta-arrestin 2 interacts with signaling proteins such as ERK1/2 (Extracellular signal-Regulated Kinases) and dishevelled proteins. These interactions highlight beta-arrestin 2's ability to modulate signal strength and duration contributing to diverse cellular responses.

Beta-arrestin 2 is implicated in conditions like heart failure and certain cancers. The aberrant regulation of beta-arrestin 2-related pathways can lead to uncontrolled cell proliferation or inadequate heart responses. Additionally beta-arrestin 2 is connected to proteins like GPCR kinases in the context of heart failure and MAPK proteins within oncogenic processes underlining its potential as a therapeutic target.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes (PubMed : 37209686, PubMed : 38175886). During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). However, the extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type. Internalized arrestin-receptor complexes traffic to intracellular endosomes, where they remain uncoupled from G-proteins. Two different modes of arrestin-mediated internalization occur. Class A receptors, like ADRB2, OPRM1, ENDRA, D1AR and ADRA1B dissociate from beta-arrestin at or near the plasma membrane and undergo rapid recycling. Class B receptors, like AVPR2, AGTR1, NTSR1, TRHR and TACR1 internalize as a complex with arrestin and traffic with it to endosomal vesicles, presumably as desensitized receptors, for extended periods of time. Receptor resensitization then requires that receptor-bound arrestin is removed so that the receptor can be dephosphorylated and returned to the plasma membrane. Mediates endocytosis of CCR7 following ligation of CCL19 but not CCL21. Involved in internalization of P2RY1, P2RY4, P2RY6 and P2RY11 and ATP-stimulated internalization of P2RY2. Involved in phosphorylation-dependent internalization of OPRD1 and subsequent recycling or degradation. Involved in ubiquitination of IGF1R. Beta-arrestins function as multivalent adapter proteins that can switch the GPCR from a G-protein signaling mode that transmits short-lived signals from the plasma membrane via small molecule second messengers and ion channels to a beta-arrestin signaling mode that transmits a distinct set of signals that are initiated as the receptor internalizes and transits the intracellular compartment. Acts as a signaling scaffold for MAPK pathways such as MAPK1/3 (ERK1/2) and MAPK10 (JNK3). ERK1/2 and JNK3 activated by the beta-arrestin scaffold are largely excluded from the nucleus and confined to cytoplasmic locations such as endocytic vesicles, also called beta-arrestin signalosomes. Acts as a signaling scaffold for the AKT1 pathway. GPCRs for which the beta-arrestin-mediated signaling relies on both ARRB1 and ARRB2 (codependent regulation) include ADRB2, F2RL1 and PTH1R. For some GPCRs the beta-arrestin-mediated signaling relies on either ARRB1 or ARRB2 and is inhibited by the other respective beta-arrestin form (reciprocal regulation). Increases ERK1/2 signaling in AGTR1- and AVPR2-mediated activation (reciprocal regulation). Involved in CCR7-mediated ERK1/2 signaling involving ligand CCL19. Is involved in type-1A angiotensin II receptor/AGTR1-mediated ERK activity. Is involved in type-1A angiotensin II receptor/AGTR1-mediated MAPK10 activity. Is involved in dopamine-stimulated AKT1 activity in the striatum by disrupting the association of AKT1 with its negative regulator PP2A. Involved in AGTR1-mediated chemotaxis. Appears to function as signaling scaffold involved in regulation of MIP-1-beta-stimulated CCR5-dependent chemotaxis. Involved in attenuation of NF-kappa-B-dependent transcription in response to GPCR or cytokine stimulation by interacting with and stabilizing CHUK. Suppresses UV-induced NF-kappa-B-dependent activation by interacting with CHUK. The function is promoted by stimulation of ADRB2 and dephosphorylation of ARRB2. Involved in p53/TP53-mediated apoptosis by regulating MDM2 and reducing the MDM2-mediated degradation of p53/TP53. May serve as nuclear messenger for GPCRs. Upon stimulation of OR1D2, may be involved in regulation of gene expression during the early processes of fertilization. Also involved in regulation of receptors other than GPCRs. Involved in endocytosis of TGFBR2 and TGFBR3 and down-regulates TGF-beta signaling such as NF-kappa-B activation. Involved in endocytosis of low-density lipoprotein receptor/LDLR. Involved in endocytosis of smoothened homolog/Smo, which also requires GRK2. Involved in endocytosis of SLC9A5. Involved in endocytosis of ENG and subsequent TGF-beta-mediated ERK activation and migration of epithelial cells. Involved in Toll-like receptor and IL-1 receptor signaling through the interaction with TRAF6 which prevents TRAF6 autoubiquitination and oligomerization required for activation of NF-kappa-B and JUN (PubMed : 26839314). Involved in insulin resistance by acting as insulin-induced signaling scaffold for SRC, AKT1 and INSR. Involved in regulation of inhibitory signaling of natural killer cells by recruiting PTPN6 and PTPN11 to KIR2DL1. Involved in IL8-mediated granule release in neutrophils. Involved in the internalization of the atypical chemokine receptor ACKR3. Acts as an adapter protein coupling FFAR4 receptor to specific downstream signaling pathways, as well as mediating receptor endocytosis (PubMed : 22282525, PubMed : 23809162). During the activation step of NLRP3 inflammasome, directly associates with NLRP3 leading to inhibition of pro-inflammatory cytokine release and inhibition of inflammation (PubMed : 23809162).

See full target information ARRB2

대체 명칭 보기

ARB2, ARR2, ARRB2, Beta-arrestin-2, Arrestin beta-2, Non-visual arrestin-3

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제품이 사용된 논문 (32)

Recent publications for all applications. Explore the 전체 목록 and refine your search

NPJ precision oncology 9:80 PubMed40119070

2025

ARRB2 promotes cervical cancer progression via stabilizing CDC25A mRNA through m6A-IGF2BP1-dependent manner.

Applications

Unspecified application

Species

Unspecified reactive species

Lijie Li,Jie Zeng,Mengying Liu,Hui Cheng,Yuyin He,Sili He,Chen Wang

Molecular medicine (Cambridge, Mass.) 31:31 PubMed39881219

2025

Sodium butyrate regulates macrophage polarization by TGR5/β-arrestin2 in vitro.

Applications

Unspecified application

Species

Unspecified reactive species

Miao Liu,Wen-Jie Xie,Xu Zhang,Wei Wu,Guang Li,Lu Wang

Theranostics 13:4745-4761 PubMed37771787

2023

A genome-wide CRISPR/Cas9 screen identifies DNA-PK as a sensitiser to Lutetium-DOTA-octreotate radionuclide therapy.

Applications

Unspecified application

Species

Unspecified reactive species

Kelly Waldeck,Jessica Van Zuylekom,Carleen Cullinane,Twishi Gulati,Kaylene J Simpson,Richard W Tothill,Benjamin Blyth,Rodney J Hicks

Iranian journal of basic medical sciences 24:1428-1436 PubMed35096302

2022

Tertiary butylhydroquinone alleviated liver steatosis and increased cell survival via β-arrestin-2/PI3K/AKT pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Tian-Tian Zhu,Chao-Nan Zhu,Yue Qiu,Qian-Shuai Li,Xin Yu,Guo-Jie Hao,Ping Song,Jian Xu,Peng Li,Ya-Ling Yin

Bioengineered 13:38-47 PubMed34787064

2021

β-arrestin-2 alleviates rheumatoid arthritis injury by suppressing NLRP3 inflammasome activation and NF- κB pathway in macrophages.

Applications

Unspecified application

Species

Unspecified reactive species

Feng Cao,Cheng Huang,Jiwei Cheng,Zhaochun He

Gastroenterology report 9:154-165 PubMed34026223

2021

Sodium butyrate protects against lipopolysaccharide-induced liver injury partially via the GPR43/ β-arrestin-2/NF-κB network.

Applications

Unspecified application

Species

Unspecified reactive species

Qian-Jiang Luo,Mei-Xing Sun,Yun-Wei Guo,Si-Wei Tan,Xiao-Ying Wu,Kodjo-Kunale Abassa,Li Lin,Hui-Ling Liu,Jie Jiang,Xiu-Qing Wei

Journal of immunology (Baltimore, Md. : 1950) 206:2623-2637 PubMed34001657

2021

β-Arrestin 2 Regulates Inflammatory Responses against Infection through ERK1/2 Signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Qian Wen,Yanfen Li,Zhenyu Han,Honglin Liu,Shimeng Zhang,Yaoxin Chen,Jianchun He,Xialin Du,Yuling Fu,Lijie Zhang,Zelin Zhang,Yulan Huang,Xinying Zhou,Chaoying Zhou,Shengfeng Hu,Li Ma

Biochemical and biophysical research communications 557:69-76 PubMed33862462

2021

Remifentanil preconditioning promotes liver regeneration via upregulation of β-arrestin 2/ERK/cyclin D1 pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Ling Zhu,Yan-Yu Zhou,Zhi Zhang,Su-Qing Yin,Dong-Dong Lv,Yu-Ling Wu,Bao-Shan Wang,Meng-Han Mao,Ying-Fu Jiao,Wei-Feng Yu,Po Gao,Li-Qun Yang

Nature communications 11:6000 PubMed33243993

2020

β-arrestin 2 as an activator of cGAS-STING signaling and target of viral immune evasion.

Applications

Unspecified application

Species

Unspecified reactive species

Yihua Zhang,Manman Li,Liuyan Li,Gui Qian,Yu Wang,Zijuan Chen,Jing Liu,Chao Fang,Feng Huang,Daqiao Guo,Quanming Zou,Yiwei Chu,Dapeng Yan

British journal of pharmacology 178:913-932 PubMed33226635

2020

PAR2 induces ovarian cancer cell motility by merging three signalling pathways to transactivate EGFR.

Applications

Unspecified application

Species

Unspecified reactive species

Yuhong Jiang,Junxian Lim,Kai-Chen Wu,Weijun Xu,Jacky Y Suen,David P Fairlie

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Beta Arrestin 2 antibody [3G1]

Flow Cytometry - Anti-Beta Arrestin 2 antibody [3G1] (AB54790)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Beta Arrestin 2 antibody [3G1] (AB54790)

Immunocytochemistry/ Immunofluorescence - Anti-Beta Arrestin 2 antibody [3G1] (AB54790)

Western blot - Anti-Beta Arrestin 2 antibody [3G1] (AB54790)

Western blot - Anti-Beta Arrestin 2 antibody [3G1] (AB54790)

Western blot - Anti-Beta Arrestin 2 antibody [3G1] (AB54790)

Western blot - Anti-Beta Arrestin 2 antibody [3G1] (AB54790)

Western blot - Anti-Beta Arrestin 2 antibody [3G1] (AB54790)

Western blot - Anti-Beta Arrestin 2 antibody [3G1] (AB54790)

주요 정보

Host species

Clonality

Clone number

Isotype

Light chain 타입

Carrier free

Reacts with

Applications

Immunogen

대체품

Primary Antibodies

Primary Antibodies

Primary Antibodies

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

제품 세부 정보

특성 및 보관 정보

제형

Purification 테크닉

보관 버퍼

배송 시 보관 조건

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