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AB26009

Biotin Anti-CD98 antibody [MEM-108]

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Anti-CD98 antibody [MEM-108] conjugated to Biotin - suitable for flow cytometry, and reacts with human samples. Clone [MEM-108] is a mouse monoclonal antibody cited in 5 publications.
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Flow Cytometry - Biotin Anti-CD98 antibody [MEM-108] (AB26009)
  • Flow Cyt

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Flow Cytometry - Biotin Anti-CD98 antibody [MEM-108] (AB26009)

Separation of human monocytes (red-filled) from CD98 negative blood debris (black-dashed) in flow cytometry analysis (surface staining) of human peripheral whole blood using ab25323 at 2 μg/ml.

Flow Cytometry - Biotin Anti-CD98 antibody [MEM-108] (AB26009)
  • Flow Cyt

Unknown

Flow Cytometry - Biotin Anti-CD98 antibody [MEM-108] (AB26009)

Flow cytometry surface staining pattern of human peripheral whole blood stained using ab25323 at 2 μg/ml.

주요 정보

Host species

Mouse

Clonality

Monoclonal

Clone number

MEM-108

Isotype

IgG1

Conjugation

Biotin

Excitation/Emission
Carrier free

No

Reacts with

Human

Applications

Flow Cyt

applications

Immunogen

Cell preparation containing SLC3A2 protein. The exact immunogen used to generate this antibody is proprietary information.

P08195

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대체품

Primary Antibodies

AB193364

Anti-CD98 antibody [UM7F8]

  • 0
  • 0
Primary Antibodies

AB2528

Anti-CD98 antibody [MEM-108] - Plasma Membrane Marker

Lab Essentials

Flow Cytometry - Anti-CD98 antibody [MEM-108] - Plasma Membrane Marker (AB2528)

  • 3
  • 3
Primary Antibodies

AB26010

FITC Anti-CD98 antibody [MEM-108]

Flow Cytometry - FITC Anti-CD98 antibody [MEM-108] (AB26010)

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Primary Antibodies

AB91297

PerCP Anti-CD98 antibody [FG 1/8]

  • 0
  • 0
Primary Antibodies

AB123635

CF405M Anti-CD98 antibody [FG1/8]

Flow Cytometry - CF405M Anti-CD98 antibody [FG1/8] (AB123635)

  • 0
  • 0
Primary Antibodies

AB23495

Anti-CD98 antibody [44D7] - Plasma Membrane Marker

Lab Essentials

Flow Cytometry - Anti-CD98 antibody [44D7] - Plasma Membrane Marker (AB23495)

  • 3
  • 2
Primary Antibodies

AB232725

Anti-CD98 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD98 antibody (AB232725)

  • 0
  • 0

보완 제품

Assay Kits

AB83374

Branched Chain Amino Acid Assay Kit / BCAA Assay Kit

Functional Studies - Branched Chain Amino Acid Assay Kit / BCAA Assay Kit (AB83374)

  • 0
  • 0
Primary Antibodies

AB312914

Alexa Fluor® 594 Anti-CD11b antibody [M1/70]

Recombinant

Flow Cytometry - Alexa Fluor® 594 Anti-CD11b antibody [M1/70] (AB312914)

  • 0
  • 0
Primary Antibodies

AB24982

Cy5 ® Anti-CD45.1 antibody [A20]

  • 0
  • 0
Primary Antibodies

AB303467

Alexa Fluor® 647 Anti-Ly6g antibody [EPR22909-135]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Alexa Fluor® 647 Anti-Ly6g antibody [EPR22909-135] (AB303467)

  • 0
  • 0
Primary Antibodies

AB237365

Alexa Fluor® 647 Anti-CD8 alpha antibody [EPR21769]

BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Alexa Fluor® 647 Anti-CD8 alpha antibody [EPR21769] (AB237365)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "3 µg/mL", "FlowCyt-species-notes": "<p></p>" } } }
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제품 세부 정보

The antibody is conjugated with Biotin-LC-NHS under optimum conditions. The reagent is free of unconjugated biotin.
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특성 및 보관 정보

제형
Liquid
보관 버퍼
pH: 7.4 Preservative: 0.097% Sodium azide Constituents: PBS
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

CD98 also known as CD98hc CD98 protein or LAT1/CD98 is a type II membrane protein often found in association with the heavy chains of amino acid transporters like LAT1. It has a molecular mass of approximately 85-100 kDa. CD98 is widely expressed in numerous tissues including the liver kidney and various tumors. It plays an important role in cellular processes by facilitating the transport of amino acids across plasma membranes which is essential for maintaining cellular homeostasis and proliferation.
Biological function summary

CD98 forms a complex with light chains of the heterodimeric amino acid transporters such as LAT1 and LAT2. This interaction enhances the uptake of neutral amino acids into cells. CD98 also interacts with integrins influencing cell adhesion and migration which are critical for cellular signaling and response. Through these interactions CD98 impacts not only cell survival and growth but also immune responses and angiogenesis.

Pathways

CD98 is a vital component of the mTOR signaling pathway influencing cell growth and proliferation. It also plays a part in the integrin signaling pathway which regulates cell adhesion and migration. In these pathways CD98 works closely with proteins like FG1 and mTORC1. These relationships enable it to modulate cellular responses to nutritional availability and mechanical cues from the environment.

CD98 expression and function have links to cancer and autoimmune diseases. High expression levels of CD98 are observed in various cancers such as lymphomas where it correlates with increased tumor growth and poor prognosis. In autoimmune disorders like rheumatoid arthritis CD98 influences immune cell activation and migration. Proteins such as CP1 and FG1 interact with CD98 contributing to disease pathology by affecting cellular and immune responses.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Acts as a chaperone that facilitates biogenesis and trafficking of functional transporters heterodimers to the plasma membrane. Forms heterodimer with SLC7 family transporters (SLC7A5, SLC7A6, SLC7A7, SLC7A8, SLC7A10 and SLC7A11), a group of amino-acid antiporters (PubMed : 10574970, PubMed : 10903140, PubMed : 11557028, PubMed : 30867591, PubMed : 33298890, PubMed : 33758168, PubMed : 34880232, PubMed : 9751058, PubMed : 9829974, PubMed : 9878049). Heterodimers function as amino acids exchangers, the specificity of the substrate depending on the SLC7A subunit. Heterodimers SLC3A2/SLC7A6 or SLC3A2/SLC7A7 mediate the uptake of dibasic amino acids (PubMed : 10903140, PubMed : 9829974). Heterodimer SLC3A2/SLC7A11 functions as an antiporter by mediating the exchange of extracellular anionic L-cystine and intracellular L-glutamate across the cellular plasma membrane (PubMed : 34880232). SLC3A2/SLC7A10 translocates small neutral L- and D-amino acids across the plasma membrane (By similarity). SLC3A2/SLC75 or SLC3A2/SLC7A8 translocates neutral amino acids with broad specificity, thyroid hormones and L-DOPA (PubMed : 10574970, PubMed : 11389679, PubMed : 11557028, PubMed : 11564694, PubMed : 11742812, PubMed : 12117417, PubMed : 12225859, PubMed : 12716892, PubMed : 15980244, PubMed : 30867591, PubMed : 33298890, PubMed : 33758168). SLC3A2 is essential for plasma membrane localization, stability, and the transport activity of SLC7A5 and SLC7A8 (PubMed : 10391915, PubMed : 10574970, PubMed : 11311135, PubMed : 15769744, PubMed : 33066406). When associated with LAPTM4B, the heterodimer SLC7A5 is recruited to lysosomes to promote leucine uptake into these organelles, and thereby mediates mTORC1 activation (PubMed : 25998567). Modulates integrin-related signaling and is essential for integrin-dependent cell spreading, migration and tumor progression (PubMed : 11121428, PubMed : 15625115).. (Microbial infection) In case of hepatitis C virus/HCV infection, the complex formed by SLC3A2 and SLC7A5/LAT1 plays a role in HCV propagation by facilitating viral entry into host cell and increasing L-leucine uptake-mediated mTORC1 signaling activation, thereby contributing to HCV-mediated pathogenesis.. (Microbial infection) Acts as a receptor for malaria parasite Plasmodium vivax (Thai isolate) in immature red blood cells.
See full target information SLC3A2

대체 명칭 보기

CD98, MDU1, SLC3A2, Amino acid transporter heavy chain SLC3A2, 4F2 cell-surface antigen heavy chain, 4F2 heavy chain antigen, Lymphocyte activation antigen 4F2 large subunit, Solute carrier family 3 member 2, 4F2hc
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

The Journal of biological chemistry 277:7955-61 PubMed11773067

2002

Molecular mechanisms involved in CD43-mediated apoptosis of TF-1 cells. Roles of transcription Daxx expression, and adhesion molecules.

Applications

Unspecified application

Species

Unspecified reactive species

Lukás Cermák,Sárka Símová,Alexandros Pintzas,Vaclav Horejsí,Ladislav Andera
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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