AB48287
Biotin Anti-Glucagon antibody
5
(1 리뷰)
|
(3 제품이 사용된 논문 )
Anti-Glucagon antibody conjugated to Biotin is a rabbit polyclonal antibody suitable for ELISA, IHC-P, IP, RIA, and reacts with human samples.
대체품
Primary Antibodies
AB92517
Anti-Glucagon antibody [EP3070]
RabMAb|Recombinant|Lab Essentials|20ul selling size
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Glucagon antibody [EP3070] (AB92517)](https://content.abcam.com/products/images/glucagon-antibody-ep3070-ab92517--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img115110.jpg)
- 5
- 8
Primary Antibodies
AB108426
Anti-Glucagon antibody [EPR3070-45]
RabMAb|Recombinant|Lab Essentials
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Glucagon antibody [EPR3070-45] (AB108426)](https://content.abcam.com/products/images/glucagon-antibody-epr3070-45-ab108426--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img119530.jpg)
- 0
- 0
Primary Antibodies
AB167078
Anti-Glucagon antibody [EP3070] - BSA and Azide free
RabMAb|Recombinant
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Glucagon antibody [EP3070] - BSA and Azide free (AB167078)](https://content.abcam.com/products/images/glucagon-antibody-ep3070-bsa-and-azide-free-ab167078--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img98714.jpg)
- 0
- 0
Primary Antibodies
AB226035
Anti-Glucagon antibody [EPR3070-45] - BSA and Azide free
RabMAb|Recombinant
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Glucagon antibody [EPR3070-45] - BSA and Azide free (AB226035)](https://content.abcam.com/products/images/glucagon-antibody-epr3070-45-bsa-and-azide-free-ab226035--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img119530.jpg)
- 0
- 0
보완 제품
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Glucagon antibody [K79bB10] (AB10988)](https://content.abcam.com/products/images/glucagon-antibody-k79bb10-ab10988--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img76986.jpg)
Primary Antibodies
AB282459
Anti-Insulin antibody [RM1019]
RabMAb|Recombinant|Lab Essentials|20ul selling size|Trial Size|Trial Size|Trial Size|Trial Size|Trial Size|Trial Size|Trial Size|Trial Size|Trial Size|Trial Size
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Insulin antibody [RM1019] (AB282459)](https://content.abcam.com/products/images/insulin-antibody-rm1019-ab282459--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img164714.jpg)
- 0
- 0
Reactivity 정보
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특성 및 보관 정보
제형
Liquid
Purification 테크닉
Affinity purification Protein G
보관 버퍼
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.25% BSA
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
보관 정보
Avoid freeze / thaw cycle
추가 정보
This supplementary information is collated from multiple sources and compiled automatically.
Glucagon also known as the “hunger hormone" is a 29-amino acid peptide hormone with a mass of approximately 3.5 kDa. It plays an important role in glucose metabolism and regulation of blood sugar levels. The human pancreas specifically the alpha cells located in the islets of Langerhans synthesizes and secretes glucagon. This hormone binds to glucagon receptors which are widely expressed across tissues including the liver and kidney where it initiates a cascade of signaling events.
Biological function summary
Glucagon plays a central role in maintaining glucose homeostasis. It increases blood glucose by promoting gluconeogenesis and glycogenolysis in the liver. Though glucagon mainly acts independently it exhibits significant interactions with other metabolic hormones such as insulin. This interaction helps balance blood sugar levels as glucagon and insulin work in opposition to ensure optimal blood glucose regulation.
Pathways
Glucagon primarily impacts the cAMP signaling pathway significantly increasing intracellular cAMP levels. This pathway initiates a complex series of downstream events including increased enzyme activity for gluconeogenesis and glycogen breakdown in the liver. Glucagon also cross-talks with insulin signaling pathways enabling the intertwined regulation of metabolism through these hormones and maintaining glucose balance.
Glucagon is closely linked to diabetes and hyperglycemia. Individuals with diabetes often exhibit dysregulated glucagon secretion leading to unstable blood sugar levels. Glucagon interacts with insulin in the pathology of diabetes where an improper balance between these hormones can exacerbate the disease. The understanding of glucagon's role in these conditions makes it a target for new therapeutic strategies including recombinant glucagon treatments and assays.
제품 프로토콜
For this product, it's our understanding that no specific protocols are required. You can visit:
- Visit the General protocols
- Visit the Troubleshooting
타겟 정보
Glucagon. Plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia. Plays an important role in initiating and maintaining hyperglycemic conditions in diabetes. Binds to and activates the glucagon receptor GCGR, which couples to the G(s) G protein and elevates intracellular cAMP, triggering downstream metabolic responses (PubMed : 32193322).. Glucagon-like peptide 1. Potent stimulator of glucose-dependent insulin release (PubMed : 22037645, PubMed : 40446798). Also stimulates insulin release in response to IL6 (PubMed : 22037645). Plays important roles on gastric motility and the suppression of plasma glucagon levels (PubMed : 10605628, PubMed : 14719035, PubMed : 12554744). May be involved in the suppression of satiety and stimulation of glucose disposal in peripheral tissues, independent of the actions of insulin (PubMed : 10605628, PubMed : 14719035, PubMed : 12554744). Has growth-promoting activities on intestinal epithelium (PubMed : 10605628, PubMed : 14719035, PubMed : 12554744). May also regulate the hypothalamic pituitary axis (HPA) via effects on LH, TSH, CRH, oxytocin, and vasopressin secretion (PubMed : 10605628, PubMed : 14719035, PubMed : 12554744). Increases islet mass through stimulation of islet neogenesis and pancreatic beta cell proliferation (PubMed : 10605628, PubMed : 14719035, PubMed : 12554744). Inhibits beta cell apoptosis (PubMed : 10605628, PubMed : 14719035, PubMed : 12554744).. Glucagon-like peptide 2. Stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a key role in nutrient homeostasis, enhancing nutrient assimilation through enhanced gastrointestinal function, as well as increasing nutrient disposal. Stimulates intestinal glucose transport and decreases mucosal permeability.. Oxyntomodulin. Significantly reduces food intake. Inhibits gastric emptying in humans. Suppression of gastric emptying may lead to increased gastric distension, which may contribute to satiety by causing a sensation of fullness.. Glicentin. May modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life.
대체 명칭 보기
Pro-glucagon, GCG
제품이 사용된 논문 (3)
Recent publications for all applications. Explore the 전체 목록and refine your search
Clinical proteomics 19:16 PubMed35590248
2022
CN: glucagon-based novel isotope dilution mass spectrometry method for measurement of glucagon metabolism in humans.
Applications
Unspecified application
Species
Unspecified reactive species
Santosh Renuse,Linda M Benson,Patrick M Vanderboom,F N U Ruchi,Yogesh R Yadav,Kenneth L Johnson,Benjamin C Brown,Jane A Peterson,Rita Basu,Daniel J McCormick,Akhilesh Pandey,Ananda Basu
British journal of pharmacology 177:1556-1567 PubMed31713846
2020
Phosphatidylinositol 3-kinase-δ controls endoplasmic reticulum membrane fluidity and permeability in fungus-induced allergic inflammation in mice.
Applications
Unspecified application
Species
Unspecified reactive species
Hwa-Young Lee,Geum-Hwa Lee,Hyung-Ryong Kim,Yong-Chul Lee,Han-Jung Chae
Immunity 47:928-942.e7 PubMed29166590
2017
Interleukin-33-Activated Islet-Resident Innate Lymphoid Cells Promote Insulin Secretion through Myeloid Cell Retinoic Acid Production.
Applications
Unspecified application
Species
Unspecified reactive species
Elise Dalmas,Frank M Lehmann,Erez Dror,Stephan Wueest,Constanze Thienel,Marcela Borsigova,Marc Stawiski,Emmanuel Traunecker,Fabrizio C Lucchini,Dianne H Dapito,Sandra M Kallert,Bruno Guigas,Francois Pattou,Julie Kerr-Conte,Pierre Maechler,Jean-Philippe Girard,Daniel Konrad,Christian Wolfrum,Marianne Böni-Schnetzler,Daniela Finke,Marc Y Donath
Product promise
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