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AB239244

Biotin Anti-Kappa light chain antibody [TB28-2]

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Anti-Kappa light chain antibody [TB28-2] conjugated to Biotin - suitable for flow cytometry, and reacts with human samples. Clone [TB28-2] is a mouse monoclonal antibody cited in 12 publications.
1 이미지
Flow Cytometry - Biotin Anti-Kappa light chain antibody [TB28-2] (AB239244)
  • Flow Cyt

Supplier Data

Flow Cytometry - Biotin Anti-Kappa light chain antibody [TB28-2] (AB239244)

Surface staining of kappa light chains in human peripheral blood cells with ab239244 (TB28-2) biotin, streptavidin-PE.

관련 conjugated 항체와 다양한 조성의 항체 (4)

  • 660 APC

    APC Anti-Kappa light chain antibody [TB28-2]

  • 785 APC/Cy7®

    APC/Cy7® Anti-Kappa light chain antibody [TB28-2]

  • 519 FITC

    FITC Anti-Kappa light chain antibody [TB28-2]

  • 578 PE

    PE Anti-Kappa light chain antibody [TB28-2]

주요 정보

Host species

Mouse

Clonality

Monoclonal

Clone number

TB28-2

Isotype

IgG1

Conjugation

Biotin

Excitation/Emission
Carrier free

No

Reacts with

Human

Applications

Flow Cyt

applications

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보완 제품

Assay Kits

AB157709

Human Kappa ELISA Kit

Sandwich ELISA - Human Kappa ELISA Kit (AB157709)

  • 0
  • 0
Primary Antibodies

AB79558

Anti-Kappa light chain antibody [A8B5]

Flow Cytometry - Anti-Kappa light chain antibody [A8B5] (AB79558)

  • 0
  • 0
Primary Antibodies

AB1050

Anti-Kappa light chain antibody [MEM-09]

Flow Cytometry - Anti-Kappa light chain antibody [MEM-09] (AB1050)

  • 4
  • 1
Secondary Antibodies

AB150080

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 594)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 594) (AB150080)

  • 5
  • 3
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "1-12 µg/mL", "FlowCyt-species-notes": "<p></p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Size-exclusion chromatography
Purification 관련 사항
The purified antibody is conjugated with Biotin-LC-NHS under optimum conditions.The reagent is free of unconjugated biotin.
보관 버퍼
pH: 7.4 Preservative: 0.0975% Sodium azide Constituents: PBS
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle|Store in the dark
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

The kappa light chain alternatively known as Ig kappa chain is a component of immunoglobulins which are important for immune response. This protein has a molecular mass of roughly 25 kDa. It predominantly expresses in B lymphocytes where it pairs with heavy chains to form antibodies. Its expression is indicative of mature B cell functions serving as a marker for certain types of immune cells. The kappa light chain can also be detected outside of cells circulating in the blood and other bodily fluids.
Biological function summary

Kappa light chains are integral to the structure and function of antibodies. As part of the immunoglobulin molecule these chains contribute to antigen specificity by combining with heavy chains. Together they form the antigen-binding site. The kappa light chain is not part of a multiprotein complex; rather it directly participates in the antibody response. The presence of either kappa or lambda light chains can determine the particularities of antibody characteristics.

Pathways

Kappa light chains are elements of the immunological pathways notably the adaptive immune response. They interact with other proteins like immunoglobulin heavy chains to neutralize pathogens. The constant region of the kappa chain plays a role in determining the isotype of immunoglobulins which affects how antibodies mediate immune effector functions. Cross-linking of surface immunoglobulin by antigens can trigger B cell activation an essential step in the adaptive immune system.

Kappa light chains associate closely with multiple myeloma and certain types of lymphomas. Overproduction of kappa light chains in these diseases results in high levels detectable in the serum or urine which can be used diagnostically as markers. Also dysregulation of kappa chains correlates with autoimmune disorders whereby the immune system incorrectly targets its tissues. In disorders like these the interplay between kappa and lambda chains often arises showing imbalance between the two as a sign of abnormal B cell activity.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Constant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed : 20176268, PubMed : 22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed : 17576170, PubMed : 20176268).
See full target information IGKC

대체 명칭 보기

Immunoglobulin kappa constant, Ig kappa chain C region, Ig kappa chain C region AG, Ig kappa chain C region CUM, Ig kappa chain C region EU, Ig kappa chain C region OU, Ig kappa chain C region ROY, Ig kappa chain C region TI, IGKC
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 12:e2416711 PubMed40285610

2025

Extracellular Vesicular Delta-Like Ligand 3 and Subtype Transcription Factors for Small Cell Lung Cancer Diagnosis.

Applications

Unspecified application

Species

Unspecified reactive species

Hong Li,Chi-Ling Chiang,Kwang Joo Kwak,Hsin-Lun Lee,Xinyu Wang,Giulia Romano,Michela Saviana,Robin Toft,Tai-Shan Cheng,Yuehshih Chang,Bi-Da Hsiang,Guan-Wan Liu,Xiaokui Mo,Yifan Ma,Junjie Pan,Xilal Y Rima,Truc Nguyen Kim,Eduardo Reategui,Chia-Ning Shen,Yeh-Shiu Chu,Carlo Croce,Peter Mu-Hsin Chang,Yi-Chen Yeh,David P Carbone,Chi-Ying F Huang,Chi-Lu Chiang,Patrick Nana-Sinkam,L James Lee
제품이 사용된 논문 모두 보기
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Product promise

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